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- W2145502034 endingPage "1134" @default.
- W2145502034 startingPage "1109" @default.
- W2145502034 abstract "Nucleoside analogues are widely used for the treatment of antiviral infections and anticancer chemotherapy. However, many nucleoside analogues suffer from poor oral bioavailability due to their high polarity and low intestinal permeability. In order to improve oral absorption of these polar drugs, prodrugs have been employed to increase lipophilicity by chemical modification of the parent. Alternatively, prodrugs targeting transporters present in the intestine have been exploited to facilitate the transport of the nucleoside analogues. Valacyclovir and valganciclovir are two successful valine ester prodrugs transported by the PepT1 transporter. Recently, research efforts have focused on design of prodrugs for tissue specific delivery to improve efficacy and safety. This review presents advances of prodrug approaches for improved oral absorption of nucleoside analogues and recent developments in tissue targeting." @default.
- W2145502034 created "2016-06-24" @default.
- W2145502034 creator A5027749037 @default.
- W2145502034 creator A5068702552 @default.
- W2145502034 creator A5087446722 @default.
- W2145502034 date "2008-03-01" @default.
- W2145502034 modified "2023-10-17" @default.
- W2145502034 title "Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting" @default.
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