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• W2145509323 abstract "Familial hypercholesterolaemia (FH) is an autosomal dominant condition characterised by increased low density lipoprotein cholesterol (LDL-c), xanthomata and premature cardiovascular disease. However, it is currently underdiagnosed and undertreated in Australasia. We sought to investigate whether interpretative commenting on lipid profiles could improve FH detection and treatment. A case–historical control study of individuals with serum LDL-c concentrations ≥ 6.5 mmol/L; 96 cases receiving an interpretative comment suggesting FH compared with 100 controls not receiving a comment. Serum LDL-c was repeated in 63 (66%) cases and 70 (70%) controls within 12 months. LDL-c decreased in 59 (94%) cases and in 61 (87%) controls. In individuals with a repeat LDL-c, a mean LDL-c reduction of 2.3 mmol/L (32%; p < 0.0001) was demonstrated in controls, compared with 3.0 mmol/L (42%; p < 0.0001) in cases; significantly greater than that of controls (p < 0.005). Interpretative comments suggesting specialist review were associated with a higher referral rate compared with controls (11.5% vs 1%, p < 0.05). Interpretative commenting was associated with a significant additional LDL-c reduction and increased specialist referrals compared with controls. However, only a minority of individuals received a specialist referral. Interpretative commenting may play an important role in the detection and management of FH." @default.
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• W2145509323 date "2013-06-01" @default.
• W2145509323 modified "2023-10-06" @default.
• W2145509323 title "Impact of interpretative commenting on lipid profiles in people at high risk of familial hypercholesterolaemia" @default.
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• W2145509323 doi "https://doi.org/10.1016/j.cca.2013.03.027" @default.
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