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- W2145515796 abstract "Objective: In this study, we aimed to search for noninvasive predictive biomarkers for prenatal diagnosis of Down’s syndrome (DS). Methods: Maternal serum samples from five DS-affected pregnant women and five DS-unaffected women were analyzed by 2D gel electrophoresis and MALDI-TOF mass spectrometry to screen for potential predictive biomarkers of DS. Then, differential levels of dGTPase, β2-glycoprotein I (β2-GPI), complement factor H-related protein 1 precursor (CFHR1) and kininogen 1 isoform 2 were further verified by western blotting tests in another independent group. Results: Statistical analysis results revealed 29 protein spots whose levels differed significantly in the DS-affected pregnancies group. Of these, the eight most differentially expressed in DP were identified successfully. Among these, levels of dGTPase, CFHR1 and kininogen 1 were elevated significantly, whereas β2-GPI was reduced in DP. Discussion: These preliminarily verified proteins might serve as potential predictive biomarkers for DS-affected pregnancies." @default.
- W2145515796 created "2016-06-24" @default.
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- W2145515796 date "2014-11-29" @default.
- W2145515796 modified "2023-09-22" @default.
- W2145515796 title "Screening and identification of potential predictive biomarkers for Down’s syndrome from second trimester maternal serum" @default.
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- W2145515796 doi "https://doi.org/10.1586/14789450.2015.979796" @default.
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