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- W2145525874 abstract "Introduction: Early reports demonstrated the safety of adherent mesenchymal stromal cell (MSC) infusions in the hematopoietic stem cell transplantation (HCT) setting, as well as clinical efficacy for treatment of steroid refractory acute graft-versus-host disease (GVHD); however, two large, Phase III randomized, placebo-controlled trials of MSC for initial therapy or steroid refractory GVHD failed to meet their primary endpoints of durable complete response. Subset analyses demonstrated efficacy in selected patient populations, contributing to recent approvals of MSC for pediatric patients in Canada and New Zealand. Areas covered: In this review, we discuss the biologic and immunomodulatory properties of MSC and potential mechanisms involved. We review the results of prior clinical trials incorporating MSC for GVHD treatment or prophylaxis, the recent approvals in Canada and New Zealand, as well as future directions in the field. Expert opinion: The role of MSC infusions, in the prophylaxis and/or treatment of GVHD after HCT, continues to be under active investigation. Whether, and how, to incorporate MSC infusions is unclear, and ongoing questions include the source tissue type and culture methods, the timing and dosage of MSC product infusions, as well as the optimal clinical trial design and endpoints for assessment of clinical response." @default.
- W2145525874 created "2016-06-24" @default.
- W2145525874 creator A5009615865 @default.
- W2145525874 creator A5082092102 @default.
- W2145525874 creator A5083412651 @default.
- W2145525874 date "2014-01-08" @default.
- W2145525874 modified "2023-10-12" @default.
- W2145525874 title "Adult adherent stromal cells in the management of graft-versus-host disease" @default.
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- W2145525874 doi "https://doi.org/10.1517/14712598.2014.866648" @default.
- W2145525874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24397853" @default.
- W2145525874 hasPublicationYear "2014" @default.
- W2145525874 type Work @default.