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• W2145562912 endingPage "1964" @default.
• W2145562912 startingPage "1957" @default.
• W2145562912 abstract "Abstract Current models of CD4+ T cell help suggest a major role for CD154 binding to CD40 expressed on dendritic cells, with a lesser role for direct T:T interactions via CD40 expressed on CD8+ T cells. However, the contribution of CD8+ T cell–derived CD40 signals during the donor-reactive T cell response to a transplant has never been studied. In this study, we examined the graft-rejection kinetics and CD4+ and CD8+ donor-reactive T cell responses under conditions in which CD40 was genetically ablated only on APC, as well as under conditions in which CD40 was genetically ablated only on donor-reactive CD8+ T cells. Our results revealed a significant role for CD8+ T cell–expressed CD40 in the augmentation of donor-reactive CD8+ T cell responses following transplantation and showed that CD40 expressed on CD8+ T cells must be inhibited to allow conversion of CD4+ T cells into induced regulatory T cells. Thus, this study identifies a major role for CD8+ T cell–derived CD40 signals as a critical switch factor that both promotes optimal differentiation of cytokine-producing CD8+ effector T cell responses and inhibits the differentiation of Ag-specific Foxp3+ induced regulatory T cells in vivo." @default.
• W2145562912 created "2016-06-24" @default.
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• W2145562912 date "2013-08-15" @default.
• W2145562912 modified "2023-09-25" @default.
• W2145562912 title "Inhibition of CD8+ T Cell–Derived CD40 Signals Is Necessary but Not Sufficient for Foxp3+ Induced Regulatory T Cell Generation In Vivo" @default.
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• W2145562912 doi "https://doi.org/10.4049/jimmunol.1300267" @default.
• W2145562912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3735715" @default.
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• W2145562912 hasPublicationYear "2013" @default.
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