FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145586918> ?p ?o ?g. }

• W2145586918 abstract "Endothelium-derived acetylcholine (eACh) plays an important role in the regulation of vascular actions in response to hypoxia, whereas arterial baroreflex (ABR) dysfunction impairs the eACh system. We investigated the effects of ABR dysfunction on ischemia-induced angiogenesis in animal models of hindlimb ischemia with a special focus on eACh/nicotinic ACh receptor (nAChR) signaling activation.Male Sprague-Dawley rats were randomly assigned to 1 of 3 groups that received (1) sham operation (control group), (2) sinoaortic denervation (SAD)-induced ABR dysfunction (SAD group), or (3) SAD rats on diet with an acetylcholinesterase inhibitor pyridostigmine (30 mg/kg per day, SAD+Pyr group). After 4 weeks of the SAD intervention, unilateral limb ischemia was surgically induced in all animals. At postoperative day 14, SAD rats exhibited impaired angiogenic action (skin temperature and capillary density) and decreased angiogenic factor expressions (vascular endothelial growth factor [VEGF] and hypoxic inducible factor [HIF]-1α) in ischemic muscles. These changes were restored by acetylcholinesterase inhibition. Rats with ABR dysfunction had lower eACh levels than did control rats, and this effect was recovered in SAD+Pyr rats. In α7-nAChR knockout mice, pyridostigmine improved ischemia-induced angiogenic responses and increased the levels of VEGF and HIF-1α. Moreover, nicotinic receptor blocker inhibited VEGF expression and VEGF receptor 2 phosphorylation (p-VEGFR2) induced by ACh analog.Thus, ABR dysfunction appears to impair ischemia-induced angiogenesis through the reduction of eACh/α7-nAChR-dependent and -independent HIF-1α/VEGF-VEGFR2 signaling activation." @default.
• W2145586918 created "2016-06-24" @default.
• W2145586918 creator A5007362010 @default.
• W2145586918 creator A5018698832 @default.
• W2145586918 creator A5030804665 @default.
• W2145586918 creator A5032811968 @default.
• W2145586918 creator A5034179596 @default.
• W2145586918 creator A5035939534 @default.
• W2145586918 creator A5039128937 @default.
• W2145586918 creator A5057728581 @default.
• W2145586918 creator A5089201688 @default.
• W2145586918 date "2014-05-22" @default.
• W2145586918 modified "2023-10-17" @default.
• W2145586918 title "Arterial Baroreflex Dysfunction Impairs Ischemia‐Induced Angiogenesis" @default.
• W2145586918 cites W1539698688 @default.
• W2145586918 cites W1594018550 @default.
• W2145586918 cites W1603203793 @default.
• W2145586918 cites W1844296510 @default.
• W2145586918 cites W1972167020 @default.
• W2145586918 cites W1973531583 @default.
• W2145586918 cites W1977485556 @default.
• W2145586918 cites W1979288467 @default.
• W2145586918 cites W1982118358 @default.
• W2145586918 cites W1989045798 @default.
• W2145586918 cites W1995467622 @default.
• W2145586918 cites W1998167013 @default.
• W2145586918 cites W2006445555 @default.
• W2145586918 cites W2008008851 @default.
• W2145586918 cites W2025382785 @default.
• W2145586918 cites W2031705593 @default.
• W2145586918 cites W2047069774 @default.
• W2145586918 cites W2048238881 @default.
• W2145586918 cites W2058166654 @default.
• W2145586918 cites W2086684197 @default.
• W2145586918 cites W2093044361 @default.
• W2145586918 cites W2107226432 @default.
• W2145586918 cites W2111441426 @default.
• W2145586918 cites W2112267683 @default.
• W2145586918 cites W2118995107 @default.
• W2145586918 cites W2121278286 @default.
• W2145586918 cites W2130417099 @default.
• W2145586918 cites W2135554005 @default.
• W2145586918 cites W2148841524 @default.
• W2145586918 cites W2156009527 @default.
• W2145586918 cites W2157478807 @default.
• W2145586918 cites W3168413161 @default.
• W2145586918 cites W4255450278 @default.
• W2145586918 doi "https://doi.org/10.1161/jaha.114.000804" @default.
• W2145586918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309071" @default.
• W2145586918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24820655" @default.
• W2145586918 hasPublicationYear "2014" @default.
• W2145586918 type Work @default.
• W2145586918 sameAs 2145586918 @default.
• W2145586918 citedByCount "15" @default.
• W2145586918 countsByYear W21455869182014 @default.
• W2145586918 countsByYear W21455869182015 @default.
• W2145586918 countsByYear W21455869182016 @default.
• W2145586918 countsByYear W21455869182017 @default.
• W2145586918 countsByYear W21455869182018 @default.
• W2145586918 countsByYear W21455869182021 @default.
• W2145586918 countsByYear W21455869182022 @default.
• W2145586918 crossrefType "journal-article" @default.
• W2145586918 hasAuthorship W2145586918A5007362010 @default.
• W2145586918 hasAuthorship W2145586918A5018698832 @default.
• W2145586918 hasAuthorship W2145586918A5030804665 @default.
• W2145586918 hasAuthorship W2145586918A5032811968 @default.
• W2145586918 hasAuthorship W2145586918A5034179596 @default.
• W2145586918 hasAuthorship W2145586918A5035939534 @default.
• W2145586918 hasAuthorship W2145586918A5039128937 @default.
• W2145586918 hasAuthorship W2145586918A5057728581 @default.
• W2145586918 hasAuthorship W2145586918A5089201688 @default.
• W2145586918 hasBestOaLocation W21455869181 @default.
• W2145586918 hasConcept C126322002 @default.
• W2145586918 hasConcept C134018914 @default.
• W2145586918 hasConcept C167734588 @default.
• W2145586918 hasConcept C2777025900 @default.
• W2145586918 hasConcept C2780394083 @default.
• W2145586918 hasConcept C2780972559 @default.
• W2145586918 hasConcept C42219234 @default.
• W2145586918 hasConcept C541997718 @default.
• W2145586918 hasConcept C71924100 @default.
• W2145586918 hasConcept C98274493 @default.
• W2145586918 hasConceptScore W2145586918C126322002 @default.
• W2145586918 hasConceptScore W2145586918C134018914 @default.
• W2145586918 hasConceptScore W2145586918C167734588 @default.
• W2145586918 hasConceptScore W2145586918C2777025900 @default.
• W2145586918 hasConceptScore W2145586918C2780394083 @default.
• W2145586918 hasConceptScore W2145586918C2780972559 @default.
• W2145586918 hasConceptScore W2145586918C42219234 @default.
• W2145586918 hasConceptScore W2145586918C541997718 @default.
• W2145586918 hasConceptScore W2145586918C71924100 @default.
• W2145586918 hasConceptScore W2145586918C98274493 @default.
• W2145586918 hasIssue "3" @default.
• W2145586918 hasLocation W21455869181 @default.
• W2145586918 hasLocation W21455869182 @default.
• W2145586918 hasLocation W21455869183 @default.
• W2145586918 hasLocation W21455869184 @default.
• W2145586918 hasOpenAccess W2145586918 @default.
• W2145586918 hasPrimaryLocation W21455869181 @default.
• W2145586918 hasRelatedWork W1966504330 @default.

• next