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- W2145606419 abstract "AbstractThe pressurised metered-dose inhaler (pMDI) has now been available for 50 years. Once regarded as an inefficient and difficult-to-use device, the technology has evolved significantly over the last few years, particularly since the introduction of novel formulations containing hydrofluoroalkane (HFA) propellants. Many modern HFA pMDIs deposit drug more efficiently in the lungs, impact less forcefully on the back of the throat and feel less cold than their chlorofluorocarbon pMDI counterparts. An improved understanding of technical factors makes it possible to design HFA pMDIs to have specific spray properties, particularly in terms of fine particle dose and spray velocity. Device technology has also progressed with the introduction of compact and convenient breath-actuated, breath-coordinated and velocity-modifying devices, which help patients to achieve a reliable lung dose. Although it faces competition from dry powder inhalers and possibly from novel soft-mist inhalers containing liquid formulations, the rejuvenated HFA pMDI is a device with a significant future for asthma, chronic obstructive pulmonary disease and wider treatment indications.Keywords:: breath-actuated inhalerdry powder inhalerpressurised metered dose inhalerspacer device DisclosureJohn Bell is a Director of Clinical Designs Ltd.AcknowledgementsThe authors thank A Newman for assistance in final preparation of the manuscript, and T Noakes of INEOS Fluor Ltd for his input regarding HFA propellants.Notes" @default.
- W2145606419 created "2016-06-24" @default.
- W2145606419 creator A5046054257 @default.
- W2145606419 creator A5061276717 @default.
- W2145606419 date "2007-05-01" @default.
- W2145606419 modified "2023-10-04" @default.
- W2145606419 title "The rejuvenated pressurised metered dose inhaler" @default.
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- W2145606419 doi "https://doi.org/10.1517/17425247.4.3.215" @default.
- W2145606419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17489650" @default.
- W2145606419 hasPublicationYear "2007" @default.
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