FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145665233> ?p ?o ?g. }

• W2145665233 endingPage "1152" @default.
• W2145665233 startingPage "1133" @default.
• W2145665233 abstract "Until recently, the concept of antibodies as in vivo therapeutics was still considered to be an exceedingly ambitious goal. However, in 2003, the situation has been completely transformed, with 14 FDA-approved monclonal antibodies (mAbs), 70 in late stage clinical (Phase II+) trials and > 1000 in preclinical development. The driving force behind this reversal in fortune has been advances in antibody engineering and the emergence of novel discovery techniques which overcame stability and immunogenicity issues that had blighted previous clinical trials of murine antibodies. For indications as diverse as inflammation, cancer and infectious disease, it is clear that unique properties of antibodies make them safe, effective and versatile therapeutics. These drugs can be used to neutralise pathogens, toxins and endogenous mediators of pathology. As cell targeting reagents, antibodies can be used to modulate cytoplasmic cascades or to 'tag' specific cells for complement- or effector-mediated lysis. Antibodies can also be modified to deliver toxic or modulatory payloads (small molecules, radionuclides and enzymes) and engineered to bind multiple epitopes (bispecifics) or even to have novel catalytic activity (abzymes). The modular structure of immunoglobulins and the availability of antibody fragment libraries also make it possible to produce variable-domain therapeutics (Fab, single-chain and domain antibodies). Although exhibiting less favourable kinetics in vivo, these fragments are simple to express and have an increased tissue penetration, making them especially useful as neutralising agents or in the delivery of payload. The number of approved antibodies is expected to increase arithmetically in the near term, as the platform is adopted as a valid alternative to small molecule discovery. This review provides an introduction to the antibody discovery process and discusses the past, present and future applications of therapeutic antibodies, with reference to several FDA-approved precedents." @default.
• W2145665233 created "2016-06-24" @default.
• W2145665233 creator A5015076767 @default.
• W2145665233 creator A5024291231 @default.
• W2145665233 date "2003-10-01" @default.
• W2145665233 modified "2023-09-25" @default.
• W2145665233 title "Antibodies as therapeutic agents: vive la renaissance!" @default.
• W2145665233 cites W1431155447 @default.
• W2145665233 cites W1488142716 @default.
• W2145665233 cites W152686753 @default.
• W2145665233 cites W1529809181 @default.
• W2145665233 cites W1533325200 @default.
• W2145665233 cites W1533495423 @default.
• W2145665233 cites W1551404386 @default.
• W2145665233 cites W1570686199 @default.
• W2145665233 cites W1571909667 @default.
• W2145665233 cites W1586068093 @default.
• W2145665233 cites W1601290042 @default.
• W2145665233 cites W1677285588 @default.
• W2145665233 cites W1868333553 @default.
• W2145665233 cites W1937245579 @default.
• W2145665233 cites W1964119722 @default.
• W2145665233 cites W1970813603 @default.
• W2145665233 cites W1971498104 @default.
• W2145665233 cites W1976001496 @default.
• W2145665233 cites W1976262436 @default.
• W2145665233 cites W1977958044 @default.
• W2145665233 cites W1983357716 @default.
• W2145665233 cites W1983494459 @default.
• W2145665233 cites W1983671192 @default.
• W2145665233 cites W1987577907 @default.
• W2145665233 cites W1989053318 @default.
• W2145665233 cites W1990002364 @default.
• W2145665233 cites W1990789777 @default.
• W2145665233 cites W1993075141 @default.
• W2145665233 cites W1993969806 @default.
• W2145665233 cites W1995356102 @default.
• W2145665233 cites W1996923120 @default.
• W2145665233 cites W1996970629 @default.
• W2145665233 cites W2001627828 @default.
• W2145665233 cites W2003366243 @default.
• W2145665233 cites W2005483507 @default.
• W2145665233 cites W2005869248 @default.
• W2145665233 cites W2006174330 @default.
• W2145665233 cites W2008724789 @default.
• W2145665233 cites W2008803651 @default.
• W2145665233 cites W2010537388 @default.
• W2145665233 cites W2010772807 @default.
• W2145665233 cites W2011261569 @default.
• W2145665233 cites W2012266601 @default.
• W2145665233 cites W2014099862 @default.
• W2145665233 cites W2014457043 @default.
• W2145665233 cites W2014457594 @default.
• W2145665233 cites W2014956545 @default.
• W2145665233 cites W2015133779 @default.
• W2145665233 cites W2016318369 @default.
• W2145665233 cites W2017720269 @default.
• W2145665233 cites W2023168923 @default.
• W2145665233 cites W2023928898 @default.
• W2145665233 cites W2025827008 @default.
• W2145665233 cites W2030522563 @default.
• W2145665233 cites W2031172875 @default.
• W2145665233 cites W2031546084 @default.
• W2145665233 cites W2031822911 @default.
• W2145665233 cites W2037956462 @default.
• W2145665233 cites W2042466093 @default.
• W2145665233 cites W2042988739 @default.
• W2145665233 cites W2043873747 @default.
• W2145665233 cites W2045490787 @default.
• W2145665233 cites W2046110140 @default.
• W2145665233 cites W2046739604 @default.
• W2145665233 cites W2049142958 @default.
• W2145665233 cites W2052637853 @default.
• W2145665233 cites W2054357328 @default.
• W2145665233 cites W2055640825 @default.
• W2145665233 cites W2060041600 @default.
• W2145665233 cites W2060099216 @default.
• W2145665233 cites W2061142243 @default.
• W2145665233 cites W2063461771 @default.
• W2145665233 cites W2063690907 @default.
• W2145665233 cites W206701898 @default.
• W2145665233 cites W2070200459 @default.
• W2145665233 cites W2071200370 @default.
• W2145665233 cites W2072183005 @default.
• W2145665233 cites W2073453630 @default.
• W2145665233 cites W2073595720 @default.
• W2145665233 cites W2075097399 @default.
• W2145665233 cites W2085853581 @default.
• W2145665233 cites W2087013294 @default.
• W2145665233 cites W2088987598 @default.
• W2145665233 cites W2091409282 @default.
• W2145665233 cites W2094682437 @default.
• W2145665233 cites W2095156669 @default.
• W2145665233 cites W2100914014 @default.
• W2145665233 cites W2101173895 @default.
• W2145665233 cites W2104385646 @default.
• W2145665233 cites W2104528117 @default.
• W2145665233 cites W2106964599 @default.

• next