FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145694973> ?p ?o ?g. }

• W2145694973 endingPage "954" @default.
• W2145694973 startingPage "943" @default.
• W2145694973 abstract "Aims The aim of this study was to test the growth inhibition activity of isothiocyanates (ITCs), defence compounds of plants, against common human microbial pathogens. Methods and Results In this study, we have tested the growth-inhibitory activity of a diverse collection of new and previously known representative ITCs of various structural classes against pathogenic bacteria, fungi and moulds by a serial dilution method. Generally, the compounds were more active against Gram-positive bacteria and fungi exhibiting species-specific bacteriostatic or bactericidal effect. The most active compounds inhibited the growth of both drug-susceptible and multi-drug-resistant (MDR) pathogens at micromolar concentrations. In the case of Mycobacterium tuberculosis, some compounds were more active against MDR, rather than against susceptible strains. The average antimicrobial activity for some of the new derivatives was significantly higher than that previously reported for the most active ITC compounds. The structure–activity relationship (SAR) established for various classes of ITC with Bacillus cereus (model organism for B. anthracis) followed a distinct pattern, thereby enabling prediction of new more efficient inhibitors. Remarkably, tested bacteria failed to develop resistance to ITC. While effectively inhibiting microbial growth, ITCs displayed moderate toxicity towards eukaryotic cells. Conclusions High antimicrobial activity coupled with moderate toxicity grants further thorough studies of the ITC compounds aimed at elucidation of their cellular targets and inhibitory mechanism. Significance and Impact of the Study This systematic study identified new ITC compounds highly active against common human microbial pathogens at the concentrations comparable with those for currently used antimicrobial drugs (e.g. rifampicin and fluconazole). Tested representative pathogens do not develop resistance to the inhibitors. These properties justify further evaluation of ITC compounds as potential antimicrobial agents for medicinal use and for industrial applications." @default.
• W2145694973 created "2016-06-24" @default.
• W2145694973 creator A5043351025 @default.
• W2145694973 creator A5044485195 @default.
• W2145694973 creator A5085564491 @default.
• W2145694973 date "2013-07-19" @default.
• W2145694973 modified "2023-09-25" @default.
• W2145694973 title "Growth-inhibitory activity of natural and synthetic isothiocyanates against representative human microbial pathogens" @default.
• W2145694973 cites W1966757313 @default.
• W2145694973 cites W1967077010 @default.
• W2145694973 cites W1970363982 @default.
• W2145694973 cites W1973007396 @default.
• W2145694973 cites W1976506031 @default.
• W2145694973 cites W1977687288 @default.
• W2145694973 cites W1977851818 @default.
• W2145694973 cites W1994926118 @default.
• W2145694973 cites W2019453869 @default.
• W2145694973 cites W2032964860 @default.
• W2145694973 cites W2035859177 @default.
• W2145694973 cites W2041550216 @default.
• W2145694973 cites W2044382720 @default.
• W2145694973 cites W2056981303 @default.
• W2145694973 cites W2066345991 @default.
• W2145694973 cites W2092438673 @default.
• W2145694973 cites W2103985935 @default.
• W2145694973 cites W2111669022 @default.
• W2145694973 cites W2115643252 @default.
• W2145694973 cites W2126853906 @default.
• W2145694973 cites W2139476788 @default.
• W2145694973 cites W2139956257 @default.
• W2145694973 cites W2148114677 @default.
• W2145694973 cites W2149294872 @default.
• W2145694973 cites W2169493815 @default.
• W2145694973 cites W2321841893 @default.
• W2145694973 cites W2998110928 @default.
• W2145694973 cites W4229493649 @default.
• W2145694973 cites W4233547126 @default.
• W2145694973 doi "https://doi.org/10.1111/jam.12288" @default.
• W2145694973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3787980" @default.
• W2145694973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23789822" @default.
• W2145694973 hasPublicationYear "2013" @default.
• W2145694973 type Work @default.
• W2145694973 sameAs 2145694973 @default.
• W2145694973 citedByCount "31" @default.
• W2145694973 countsByYear W21456949732013 @default.
• W2145694973 countsByYear W21456949732014 @default.
• W2145694973 countsByYear W21456949732015 @default.
• W2145694973 countsByYear W21456949732016 @default.
• W2145694973 countsByYear W21456949732017 @default.
• W2145694973 countsByYear W21456949732018 @default.
• W2145694973 countsByYear W21456949732019 @default.
• W2145694973 countsByYear W21456949732020 @default.
• W2145694973 countsByYear W21456949732021 @default.
• W2145694973 countsByYear W21456949732022 @default.
• W2145694973 countsByYear W21456949732023 @default.
• W2145694973 crossrefType "journal-article" @default.
• W2145694973 hasAuthorship W2145694973A5043351025 @default.
• W2145694973 hasAuthorship W2145694973A5044485195 @default.
• W2145694973 hasAuthorship W2145694973A5085564491 @default.
• W2145694973 hasBestOaLocation W21456949732 @default.
• W2145694973 hasConcept C176947019 @default.
• W2145694973 hasConcept C185592680 @default.
• W2145694973 hasConcept C202751555 @default.
• W2145694973 hasConcept C2777118263 @default.
• W2145694973 hasConcept C2778883795 @default.
• W2145694973 hasConcept C2779707156 @default.
• W2145694973 hasConcept C2780239966 @default.
• W2145694973 hasConcept C4937899 @default.
• W2145694973 hasConcept C523546767 @default.
• W2145694973 hasConcept C54355233 @default.
• W2145694973 hasConcept C55493867 @default.
• W2145694973 hasConcept C86803240 @default.
• W2145694973 hasConcept C89423630 @default.
• W2145694973 hasConceptScore W2145694973C176947019 @default.
• W2145694973 hasConceptScore W2145694973C185592680 @default.
• W2145694973 hasConceptScore W2145694973C202751555 @default.
• W2145694973 hasConceptScore W2145694973C2777118263 @default.
• W2145694973 hasConceptScore W2145694973C2778883795 @default.
• W2145694973 hasConceptScore W2145694973C2779707156 @default.
• W2145694973 hasConceptScore W2145694973C2780239966 @default.
• W2145694973 hasConceptScore W2145694973C4937899 @default.
• W2145694973 hasConceptScore W2145694973C523546767 @default.
• W2145694973 hasConceptScore W2145694973C54355233 @default.
• W2145694973 hasConceptScore W2145694973C55493867 @default.
• W2145694973 hasConceptScore W2145694973C86803240 @default.
• W2145694973 hasConceptScore W2145694973C89423630 @default.
• W2145694973 hasIssue "4" @default.
• W2145694973 hasLocation W21456949731 @default.
• W2145694973 hasLocation W21456949732 @default.
• W2145694973 hasLocation W21456949733 @default.
• W2145694973 hasLocation W21456949734 @default.
• W2145694973 hasOpenAccess W2145694973 @default.
• W2145694973 hasPrimaryLocation W21456949731 @default.
• W2145694973 hasRelatedWork W2145694973 @default.
• W2145694973 hasRelatedWork W2206289698 @default.
• W2145694973 hasRelatedWork W2467337270 @default.
• W2145694973 hasRelatedWork W2619415615 @default.
• W2145694973 hasRelatedWork W2899407247 @default.

• next