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• W2145695653 abstract "Aspects of the ‘β-agonist controversy’ have recently re-emerged with the publication of data implicating the long-acting β-agonist salmeterol in increased mortality from asthma. The reasons underlying the adverse effects of β2-agonists as a class are unclear. Polymorphisms of the β2 adrenoceptor (ADRB2), notably the variant associated with an arginine moiety at position 16 of the ADRB2 protein result in changes in in vitro receptor function. There is now consistent clinical evidence showing that, in vivo, patients with asthma harbouring the Arg-16 genotype may experience reduced lung function and an increased frequency of exacerbations when treated with regular short-acting β-agonists. This may, in part, explain why β-agonists have been associated with adverse outcomes in the past. ADRB2 genotyping of patients with severe or difficult-to-control asthma may shed light on a possible contributor to their clinical instability." @default.
• W2145695653 created "2016-06-24" @default.
• W2145695653 creator A5022959226 @default.
• W2145695653 date "2007-11-26" @default.
• W2145695653 modified "2023-10-06" @default.
• W2145695653 title "β-Adrenergic receptor polymorphisms: relationship to the β-agonist controversy and clinical implications" @default.
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• W2145695653 doi "https://doi.org/10.1517/14656566.8.18.3195" @default.
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