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• W2145710039 abstract "Apical low-conductance SK and high-conductance Ca 2+ -activated BK channels are present in distal nephron, including the cortical collecting duct (CCD). Flow-stimulated net K secretion ( J K ) in the CCD is 1) blocked by iberiotoxin, an inhibitor of BK but not SK channels, and 2) associated with an increase in [Ca 2+ ] i , leading us to conclude that BK channels mediate flow-stimulated J K . To examine the Ca 2+ dependence and sources of Ca 2+ contributing to flow-stimulated J K , J K and net Na absorption ( J Na ) were measured at slow (∼1) and fast (∼5 nl·min −1 ·mm −1 ) flow rates in rabbit CCDs microperfused in the absence of luminal Ca 2+ or after pretreatment with BAPTA-AM to chelate intracellular Ca 2+ , 2-aminoethoxydiphenyl borate (2-APB), to inhibit the inositol 1,4,5-trisphosphate (IP 3 ) receptor or thapsigargin to deplete internal stores. These treatments, which do not affect flow-stimulated J Na (Morimoto et al. Am J Physiol Renal Physiol 291: F663–F669, 2006), inhibited flow-stimulated J K . Increases in [Ca 2+ ] i stimulate exocytosis. To test whether flow induces exocytic insertion of preformed BK channels into the apical membrane, CCDs were pretreated with 10 μM colchicine (COL) to disrupt microtubule function or 5 μg/ml brefeldin-A (BFA) to inhibit delivery of channels from the intracellular pool to the plasma membrane. Both agents inhibited flow-stimulated J K but not J Na (Morimoto et al. Am J Physiol Renal Physiol 291: F663–F669, 2006), although COL but not BFA also blocked the flow-induced [Ca 2+ ] i transient. We thus speculate that BK channel-mediated, flow-stimulated J K requires an increase in [Ca 2+ ] i due, in part, to luminal Ca 2+ entry and ER Ca 2+ release, microtubule integrity, and exocytic insertion of preformed channels into the apical membrane." @default.
• W2145710039 created "2016-06-24" @default.
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• W2145710039 creator A5076247805 @default.
• W2145710039 creator A5088195948 @default.
• W2145710039 date "2007-07-01" @default.
• W2145710039 modified "2023-10-15" @default.
• W2145710039 title "Ca²⁺ dependence of flow-stimulated K secretion in the mammalian cortical collecting duct" @default.
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• W2145710039 doi "https://doi.org/10.1152/ajprenal.00057.2007" @default.
• W2145710039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17389680" @default.
• W2145710039 hasPublicationYear "2007" @default.
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