Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145754472> ?p ?o ?g. }
- W2145754472 abstract "Glatiramer acetate (GA) is a mixture of synthetic peptides used in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to investigate the effects of GA therapy on the gene expression of monocytes.Monocytes were isolated from the peripheral blood of eight RRMS patients. The blood was obtained longitudinally before the start of GA therapy as well as after one day, one week, one month and two months. Gene expression was measured at the mRNA level by microarrays.More than 400 genes were identified as up-regulated or down-regulated in the course of therapy, and we analyzed their biological functions and regulatory interactions. Many of those genes are known to regulate lymphocyte activation and proliferation, but only a subset of genes was repeatedly differentially expressed at different time points during treatment.Overall, the observed gene regulatory effects of GA on monocytes were modest and not stable over time. However, our study revealed several genes that are worthy of investigation in future studies on the molecular mechanisms of GA therapy." @default.
- W2145754472 created "2016-06-24" @default.
- W2145754472 creator A5000607833 @default.
- W2145754472 creator A5004243373 @default.
- W2145754472 creator A5055558719 @default.
- W2145754472 creator A5056430020 @default.
- W2145754472 creator A5057183948 @default.
- W2145754472 creator A5060233539 @default.
- W2145754472 creator A5061203906 @default.
- W2145754472 creator A5061531129 @default.
- W2145754472 date "2013-10-17" @default.
- W2145754472 modified "2023-09-27" @default.
- W2145754472 title "Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients" @default.
- W2145754472 cites W1504018030 @default.
- W2145754472 cites W1538328989 @default.
- W2145754472 cites W1558860870 @default.
- W2145754472 cites W1573408349 @default.
- W2145754472 cites W1601327424 @default.
- W2145754472 cites W1967025818 @default.
- W2145754472 cites W1968791377 @default.
- W2145754472 cites W1969726143 @default.
- W2145754472 cites W1980360288 @default.
- W2145754472 cites W1984185015 @default.
- W2145754472 cites W1986195187 @default.
- W2145754472 cites W1990785469 @default.
- W2145754472 cites W1993906886 @default.
- W2145754472 cites W1998105539 @default.
- W2145754472 cites W1999793296 @default.
- W2145754472 cites W2002149160 @default.
- W2145754472 cites W2002710238 @default.
- W2145754472 cites W2002967638 @default.
- W2145754472 cites W2005749589 @default.
- W2145754472 cites W2009873598 @default.
- W2145754472 cites W2010086107 @default.
- W2145754472 cites W2015916378 @default.
- W2145754472 cites W2018809310 @default.
- W2145754472 cites W2019755314 @default.
- W2145754472 cites W2020047554 @default.
- W2145754472 cites W2020502278 @default.
- W2145754472 cites W2021435584 @default.
- W2145754472 cites W2028862619 @default.
- W2145754472 cites W2035445993 @default.
- W2145754472 cites W2040547343 @default.
- W2145754472 cites W2041299813 @default.
- W2145754472 cites W2042241006 @default.
- W2145754472 cites W2043901537 @default.
- W2145754472 cites W2044387763 @default.
- W2145754472 cites W2045134556 @default.
- W2145754472 cites W2045291975 @default.
- W2145754472 cites W2045306753 @default.
- W2145754472 cites W2046784038 @default.
- W2145754472 cites W2049290292 @default.
- W2145754472 cites W2060952934 @default.
- W2145754472 cites W2066077179 @default.
- W2145754472 cites W2070487931 @default.
- W2145754472 cites W2077628984 @default.
- W2145754472 cites W2079636857 @default.
- W2145754472 cites W2085127087 @default.
- W2145754472 cites W2087426337 @default.
- W2145754472 cites W2093126196 @default.
- W2145754472 cites W2093390596 @default.
- W2145754472 cites W2093887577 @default.
- W2145754472 cites W2097391011 @default.
- W2145754472 cites W2098801818 @default.
- W2145754472 cites W2100820895 @default.
- W2145754472 cites W2101583195 @default.
- W2145754472 cites W2103683906 @default.
- W2145754472 cites W2110062742 @default.
- W2145754472 cites W2110280725 @default.
- W2145754472 cites W2117751925 @default.
- W2145754472 cites W2123255618 @default.
- W2145754472 cites W2127671643 @default.
- W2145754472 cites W2127685830 @default.
- W2145754472 cites W2134747673 @default.
- W2145754472 cites W2137531873 @default.
- W2145754472 cites W2138255346 @default.
- W2145754472 cites W2138413288 @default.
- W2145754472 cites W2140840333 @default.
- W2145754472 cites W2141919552 @default.
- W2145754472 cites W2143735963 @default.
- W2145754472 cites W2143890525 @default.
- W2145754472 cites W2145212228 @default.
- W2145754472 cites W2149622295 @default.
- W2145754472 cites W2150892663 @default.
- W2145754472 cites W2152624886 @default.
- W2145754472 cites W2156754245 @default.
- W2145754472 cites W2161060662 @default.
- W2145754472 cites W2163113037 @default.
- W2145754472 cites W2166983650 @default.
- W2145754472 cites W2171126412 @default.
- W2145754472 cites W2172287266 @default.
- W2145754472 cites W2916040650 @default.
- W2145754472 cites W4243346306 @default.
- W2145754472 cites W4253819969 @default.
- W2145754472 doi "https://doi.org/10.1186/1742-2094-10-126" @default.
- W2145754472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3852967" @default.
- W2145754472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24134771" @default.
- W2145754472 hasPublicationYear "2013" @default.
- W2145754472 type Work @default.
- W2145754472 sameAs 2145754472 @default.