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• W2145763007 abstract "A strong premature electrical stimulus (S 2 ) induces both virtual anodes and virtual cathodes. The effects of virtual electrodes on intracellular Ca 2+ concentration ([Ca 2+ ] i ) transients and ventricular fibrillation thresholds (VFTs) are unclear. We studied 16 isolated, Langendorff-perfused rabbit hearts with simultaneous voltage and [Ca 2+ ] i optical mapping and for vulnerable window determination. After baseline pacing (S 1 ), a monophasic (10 ms anodal or cathodal) or biphasic (5 ms-5 ms) S 2 was applied to the left ventricular epicardium. Virtual electrode polarizations and [Ca 2+ ] i varied depending on the S 2 polarity. Relative to the level of [Ca 2+ ] i during the S 1 beat, the [Ca 2+ ] i level 40 ms after the onset of monophasic S 2 increased by 36 ± 8% at virtual anodes and 20 ± 5% at virtual cathodes ( P < 0.01), compared with 25 ± 5% at both virtual cathode-anode and anode-cathode sites for biphasic S 2 . The VFT was significantly higher and the vulnerable window significantly narrower for biphasic S 2 than for either anodal or cathodal S 2 ( n = 7, P < 0.01). Treatment with thapsigargin and ryanodine ( n = 6) significantly prolonged the action potential duration compared with control (255 ± 22 vs. 189 ± 6 ms, P < 0.05) and eliminated the difference in VFT between monophasic and biphasic S 2 , although VFT was lower for both cases. We conclude that virtual anodes caused a greater increase in [Ca 2+ ] i than virtual cathodes. Monophasic S 2 is associated with lower VFT than biphasic S 2 , but this difference was eliminated by the inhibition of the sarcoplasmic reticulum function and the prolongation of the action potential duration. However, the inhibition of the sarcoplasmic reticulum function also reduced VFT, indicating that the [Ca 2+ ] i dynamics modulate, but are not essential, to ventricular vulnerability." @default.
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• W2145763007 date "2008-10-01" @default.
• W2145763007 modified "2023-09-27" @default.
• W2145763007 title "Virtual electrodes and the induction of fibrillation in Langendorff-perfused rabbit ventricles: the role of intracellular calcium" @default.
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• W2145763007 doi "https://doi.org/10.1152/ajpheart.00001.2008" @default.
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