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• W2145773485 startingPage "3808" @default.
• W2145773485 abstract "Polypyrimidine tract binding protein, PTB/hnRNP I, is involved in pre-mRNA processing in the nucleus and RNA localization and translation in the cytoplasm. In this report, we demonstrate that PTB shuttles between the nucleus and cytoplasm in an energy-dependent manner. Deletion mutagenesis demonstrated that a minimum of the N terminus and RNA recognition motifs (RRMs) 1 and 2 are necessary for nucleocytoplasmic shuttling. Deletion of RRM3 and 4, domains that are primarily responsible for RNA binding, accelerated the nucleocytoplasmic shuttling of PTB. Inhibition of transcription directed by either RNA polymerase II alone or all RNA polymerases yielded similar results. In contrast, selective inhibition of RNA polymerase I did not influence the shuttling kinetics of PTB. Furthermore, the intranuclear mobility of GFP-PTB, as measured by fluorescence recovery after photobleaching analyses, increased significantly in transcriptionally inactive cells compared with transcriptionally active cells. These observations demonstrate that nuclear RNA transcription and export are not necessary for the shuttling of PTB. In addition, binding to nascent RNAs transcribed by RNA polymerase II and/or III retards both the nuclear export and nucleoplasmic movement of PTB. The uncoupling of PTB shuttling and RNA export suggests that the nucleocytoplasmic shuttling of PTB may also play a regulatory role for its functions in the nucleus and cytoplasm." @default.
• W2145773485 created "2016-06-24" @default.
• W2145773485 creator A5024025988 @default.
• W2145773485 creator A5036458724 @default.
• W2145773485 creator A5052146932 @default.
• W2145773485 date "2001-12-01" @default.
• W2145773485 modified "2023-10-16" @default.
• W2145773485 title "Nucleocytoplasmic Shuttling of Polypyrimidine Tract-binding Protein Is Uncoupled from RNA Export" @default.
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• W2145773485 doi "https://doi.org/10.1091/mbc.12.12.3808" @default.
• W2145773485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/60757" @default.
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