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• W2145795438 abstract "Incel (biricodar, VX-710) restores drug sensitivity to P-glycoprotein and multidrug resistance-associated protein-1-expressing cells. This Phase I/II study evaluated the safety/tolerability, pharmacokinetics, and efficacy of VX-710 plus doxorubicin in patients with inoperable, locally advanced or metastatic, anthracycline-resistant/refractory, soft tissue sarcoma.In Phase I, i.v. bolus doxorubicin at 60, 75, or 67.5 mg/m(2) was administered 8 h after initiation of a 72-h continuous i.v. (CIV) infusion of VX-710 (120 mg/m(2)/h) to cohorts of patients to establish a maximum tolerated dose. For efficacy evaluations in Phase II, eligible patients had inoperable, locally advanced or metastatic, anthracycline-resistant/refractory soft tissue sarcoma; < or =225 mg/m(2) cumulative prior doxorubicin; and adequate hematological, liver, and kidney function. Cycles were repeated every 3 weeks.Fourteen patients were enrolled in Phase I. Myelosuppression was the dose-limiting toxicity with 75 and then 67.5 mg/m(2) doxorubicin, and the maximum tolerated dose was established at 60 mg/m(2) with VX-710, 120 mg/m(2)/h, 72-h CIV. VX-710 had no apparent effect on doxorubicin pharmacokinetics. Twenty-nine patients enrolled in Phase II were treated with VX-710, 120 mg/m(2)/h 72-h CIV, and 60 mg/m(2) doxorubicin. Among 26 evaluable patients, minimal activity was noted among 11 patients with gastrointestinal stromal tumors (GISTs); however, in 15 patients with anthracycline-resistant sarcomas of other histologies, 2 achieved partial responses and 7 patients had disease stabilization with an overall median progression-free interval of 3.4 months.Anthracycline resistance in GISTs appears to be independent of P-glycoprotein or multidrug resistance-associated protein-1 resistance mechanisms. However, the combination of VX-710 and doxorubicin resulted in objective responses or disease stabilization in patients with strictly defined anthracycline-refractory non-GIST sarcomas, which warrants further evaluation." @default.
• W2145795438 created "2016-06-24" @default.
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• W2145795438 date "2002-02-01" @default.
• W2145795438 modified "2023-09-23" @default.
• W2145795438 title "Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma." @default.
• W2145795438 cites W1490123790 @default.
• W2145795438 cites W1496021054 @default.
• W2145795438 cites W1516107827 @default.
• W2145795438 cites W1526057084 @default.
• W2145795438 cites W1780912673 @default.
• W2145795438 cites W1798881598 @default.
• W2145795438 cites W1827294812 @default.
• W2145795438 cites W1828224642 @default.
• W2145795438 cites W1866647776 @default.
• W2145795438 cites W1882650898 @default.
• W2145795438 cites W1883812557 @default.
• W2145795438 cites W1892579032 @default.
• W2145795438 cites W1918322381 @default.
• W2145795438 cites W1929606469 @default.
• W2145795438 cites W1953019510 @default.
• W2145795438 cites W1964444964 @default.
• W2145795438 cites W1967392051 @default.
• W2145795438 cites W1973522717 @default.
• W2145795438 cites W1975828433 @default.
• W2145795438 cites W1981129666 @default.
• W2145795438 cites W1981735895 @default.
• W2145795438 cites W1986962798 @default.
• W2145795438 cites W1993176598 @default.
• W2145795438 cites W2002215444 @default.
• W2145795438 cites W2004804291 @default.
• W2145795438 cites W2034328882 @default.
• W2145795438 cites W2038062325 @default.
• W2145795438 cites W2038448746 @default.
• W2145795438 cites W204666299 @default.
• W2145795438 cites W2047664336 @default.
• W2145795438 cites W2051496963 @default.
• W2145795438 cites W2052393003 @default.
• W2145795438 cites W2063884698 @default.
• W2145795438 cites W2065939180 @default.
• W2145795438 cites W2067504990 @default.
• W2145795438 cites W2070005495 @default.
• W2145795438 cites W2076956026 @default.
• W2145795438 cites W2079088649 @default.
• W2145795438 cites W2079420659 @default.
• W2145795438 cites W2080385595 @default.
• W2145795438 cites W2081120343 @default.
• W2145795438 cites W2082065626 @default.
• W2145795438 cites W2084600496 @default.
• W2145795438 cites W2092638816 @default.
• W2145795438 cites W2092722132 @default.
• W2145795438 cites W2100986293 @default.
• W2145795438 cites W2101291448 @default.
• W2145795438 cites W2102744264 @default.
• W2145795438 cites W2104336706 @default.
• W2145795438 cites W2109508638 @default.
• W2145795438 cites W2113769382 @default.
• W2145795438 cites W2123927174 @default.
• W2145795438 cites W2134281922 @default.
• W2145795438 cites W2135118095 @default.
• W2145795438 cites W2138993111 @default.
• W2145795438 cites W2153331027 @default.
• W2145795438 cites W2153365867 @default.
• W2145795438 cites W2155140832 @default.
• W2145795438 cites W2157386247 @default.
• W2145795438 cites W2160684474 @default.
• W2145795438 cites W2161378536 @default.
• W2145795438 cites W2163258576 @default.
• W2145795438 cites W2168375838 @default.
• W2145795438 cites W2171548026 @default.
• W2145795438 cites W2171620774 @default.
• W2145795438 cites W2202035925 @default.
• W2145795438 cites W2259308424 @default.
• W2145795438 cites W2260476654 @default.
• W2145795438 cites W2264714702 @default.
• W2145795438 cites W2281806383 @default.
• W2145795438 cites W2292768151 @default.
• W2145795438 cites W2320481181 @default.
• W2145795438 cites W2321195922 @default.
• W2145795438 cites W2324850882 @default.
• W2145795438 cites W2326144104 @default.
• W2145795438 cites W2397606139 @default.
• W2145795438 cites W2398407510 @default.
• W2145795438 cites W2409128379 @default.
• W2145795438 cites W2415328258 @default.
• W2145795438 cites W2416082800 @default.
• W2145795438 cites W3111650914 @default.
• W2145795438 cites W335414861 @default.
• W2145795438 cites W72747907 @default.

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