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- W2145796633 abstract "Abstract Background Losartan potassium is a non-peptide AT1 receptor drug used in the treatment of hypertension. Methods A simple, rapid, sensitive, and validated isocratic reverse-phase ultra-performance liquid chromatographic (RP-UPLC) method was developed and validated for the determination of losartan potassium (LOS) in bulk drug and tablets. The assay was developed using Waters Acquity BEH C18 (100 mm × 2.1 mm), 1.7-μm column with a mobile phase consisting of a mixture of phosphate buffer (pH 3.2) and acetonitrile (50:50 v / v ). Results An assay with a total run time of only 5 min was developed. The method monitored at 245 nm exhibited linearity over a concentration range of 2.0 to 15.0 μg mL −1 LOS. The limits of detection and quantification (signal-to-noise ratio (S/N) = 10) were found be 0.018 and 0.054 μg mL −1 , respectively. The intraday and interday RSDs were less than 1.0%. The method was validated by the determination of LOS levels in tablets where the percentage on the label claim was 100 ± 2. The accuracy of the method was further ascertained by recovery studies via the standard addition procedure, which yielded satisfactory results. Conclusion A rapid UPLC assay of LOS in bulk drug and tablets was developed and validated." @default.
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- W2145796633 date "2014-05-28" @default.
- W2145796633 modified "2023-09-27" @default.
- W2145796633 title "Rapid ultra-performance liquid chromatography assay of losartan potassium in bulk and formulations" @default.
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- W2145796633 doi "https://doi.org/10.1186/s40543-014-0033-2" @default.
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