FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145804789> ?p ?o ?g. }

• W2145804789 endingPage "E1304" @default.
• W2145804789 startingPage "E1295" @default.
• W2145804789 abstract "Recombinant adenovirus (Ad) vectors can initiate an inflammatory response, limiting its use in gene therapy and basic research. Despite increased efforts to better understand Ad infection, little is known about how it affects cellular metabolic responses. In the current studies, we explored the effects of Ad vectors on insulin signaling molecules and glucose homeostasis. Nonreplicative Ad vectors were injected into rats through the tail vein, and at 4–13 days postinjection insulin signaling and glucose tolerance were examined. Ad vector infection significantly reduced total levels of the insulin receptor (IR), and insulin receptor substrates 1 and 2 (IRS-1, IRS-2) in the liver of rats, resulting in decreased insulin-induced tyrosine phosphorylation of IR, IRS-1, and IRS-2, and decreased interaction of IRS-1 and IRS-2 with phosphoinositide 3-kinase (PI3K). In addition, Ad infection resulted in impaired systemic glucose homeostasis, which recovered by 13 days, after the protein levels of IR, IRS-1, and IRS-2 had started to normalize. Expression of a TNF inhibitor or Kupffer cell depletion attenuated the Ad vector-induced decreases of insulin signaling molecules, indicating a potential role of Kupffer cell activation in this process. These studies provide evidence that systemic administration of Ad vectors can impair insulin signaling in liver, resulting in altered systemic glucose metabolism. Thus, effects of Ad vector infection on insulin action and glucose metabolism need to be considered when Ad vectors are used in research or gene therapy and may be more broadly applicable to other viral agents." @default.
• W2145804789 created "2016-06-24" @default.
• W2145804789 creator A5004481759 @default.
• W2145804789 creator A5024440521 @default.
• W2145804789 creator A5027152326 @default.
• W2145804789 creator A5035180477 @default.
• W2145804789 date "2010-06-01" @default.
• W2145804789 modified "2023-09-24" @default.
• W2145804789 title "Adenovirus infection results in alterations of insulin signaling and glucose homeostasis" @default.
• W2145804789 cites W1574487823 @default.
• W2145804789 cites W1599588446 @default.
• W2145804789 cites W1904279749 @default.
• W2145804789 cites W1966037150 @default.
• W2145804789 cites W1967118686 @default.
• W2145804789 cites W1988084879 @default.
• W2145804789 cites W1988870963 @default.
• W2145804789 cites W1995451061 @default.
• W2145804789 cites W1996861095 @default.
• W2145804789 cites W1998493448 @default.
• W2145804789 cites W2001312576 @default.
• W2145804789 cites W2003955696 @default.
• W2145804789 cites W2014321315 @default.
• W2145804789 cites W2014356856 @default.
• W2145804789 cites W2029336962 @default.
• W2145804789 cites W2031882974 @default.
• W2145804789 cites W2033870804 @default.
• W2145804789 cites W2040837189 @default.
• W2145804789 cites W2041141973 @default.
• W2145804789 cites W2046079641 @default.
• W2145804789 cites W2054027245 @default.
• W2145804789 cites W2056732254 @default.
• W2145804789 cites W2058642356 @default.
• W2145804789 cites W2063648187 @default.
• W2145804789 cites W2063803137 @default.
• W2145804789 cites W2069711307 @default.
• W2145804789 cites W2072343603 @default.
• W2145804789 cites W2081454569 @default.
• W2145804789 cites W2091925927 @default.
• W2145804789 cites W2094042739 @default.
• W2145804789 cites W2095021139 @default.
• W2145804789 cites W2105005357 @default.
• W2145804789 cites W2107621596 @default.
• W2145804789 cites W2118688616 @default.
• W2145804789 cites W2122033091 @default.
• W2145804789 cites W2123511080 @default.
• W2145804789 cites W2124360636 @default.
• W2145804789 cites W2129215415 @default.
• W2145804789 cites W2130079031 @default.
• W2145804789 cites W2141277427 @default.
• W2145804789 cites W2149610637 @default.
• W2145804789 cites W2156829792 @default.
• W2145804789 cites W2169940712 @default.
• W2145804789 cites W2170880806 @default.
• W2145804789 cites W2175655302 @default.
• W2145804789 cites W2313269464 @default.
• W2145804789 cites W2322606593 @default.
• W2145804789 doi "https://doi.org/10.1152/ajpendo.00723.2009" @default.
• W2145804789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2886530" @default.
• W2145804789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20388825" @default.
• W2145804789 hasPublicationYear "2010" @default.
• W2145804789 type Work @default.
• W2145804789 sameAs 2145804789 @default.
• W2145804789 citedByCount "16" @default.
• W2145804789 countsByYear W21458047892012 @default.
• W2145804789 countsByYear W21458047892014 @default.
• W2145804789 countsByYear W21458047892015 @default.
• W2145804789 countsByYear W21458047892016 @default.
• W2145804789 countsByYear W21458047892017 @default.
• W2145804789 countsByYear W21458047892021 @default.
• W2145804789 countsByYear W21458047892022 @default.
• W2145804789 crossrefType "journal-article" @default.
• W2145804789 hasAuthorship W2145804789A5004481759 @default.
• W2145804789 hasAuthorship W2145804789A5024440521 @default.
• W2145804789 hasAuthorship W2145804789A5027152326 @default.
• W2145804789 hasAuthorship W2145804789A5035180477 @default.
• W2145804789 hasBestOaLocation W21458047892 @default.
• W2145804789 hasConcept C112446052 @default.
• W2145804789 hasConcept C126322002 @default.
• W2145804789 hasConcept C134018914 @default.
• W2145804789 hasConcept C17093226 @default.
• W2145804789 hasConcept C185967709 @default.
• W2145804789 hasConcept C197902417 @default.
• W2145804789 hasConcept C2777391703 @default.
• W2145804789 hasConcept C2779306644 @default.
• W2145804789 hasConcept C3018667095 @default.
• W2145804789 hasConcept C62478195 @default.
• W2145804789 hasConcept C63645605 @default.
• W2145804789 hasConcept C71924100 @default.
• W2145804789 hasConcept C86803240 @default.
• W2145804789 hasConcept C95444343 @default.
• W2145804789 hasConceptScore W2145804789C112446052 @default.
• W2145804789 hasConceptScore W2145804789C126322002 @default.
• W2145804789 hasConceptScore W2145804789C134018914 @default.
• W2145804789 hasConceptScore W2145804789C17093226 @default.
• W2145804789 hasConceptScore W2145804789C185967709 @default.
• W2145804789 hasConceptScore W2145804789C197902417 @default.
• W2145804789 hasConceptScore W2145804789C2777391703 @default.
• W2145804789 hasConceptScore W2145804789C2779306644 @default.

• next