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• W2145841125 abstract "The relative ability of a norleucine substituted cholecystokinin (CCK) analogue, U-67827E, to interact with CCK receptors and to inhibit food intake was examined across a variety of paradigms. U-67827E and CCK had identical in vitro potencies as demonstrated by their ability to induce pyloric contractions or competitively inhibit [l25I]CCK-8 binding to type A and B CCK receptors. However, the in vivo potency of U-67827E was significantly greater than that of CCK-8. In rats, U-67827E inhibited food intake with 10–100 times the potency of CCK. In rhesus monkeys, U-67827E produced significantly greater inhibitions of daily food intake and did so in a dose-dependent manner with no evidence of compensation or tolerance. U-67827E also inhibited gastric emptying for significantly longer durations than CCK. Together these results demonstrate that CCK analogues with increased in vivo bioavailability can affect food intake beyond a single meal." @default.
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• W2145841125 date "1992-01-01" @default.
• W2145841125 modified "2023-09-29" @default.
• W2145841125 title "Potent and sustained satiety actions of a cholecystokinin octapeptide analogue" @default.
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• W2145841125 doi "https://doi.org/10.1093/ajcn/55.1.286s" @default.
• W2145841125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1728841" @default.
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