Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145871617> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2145871617 endingPage "37" @default.
- W2145871617 startingPage "29" @default.
- W2145871617 abstract "In a general study of DNA adduct formation with melphalan, rats were intravenously injected with a single high dose (10 mg kg(-1)). Adduct formation was studied at the nucleoside level in the target organs liver, bone marrow, kidney and blood with the use of 2D liquid chromatography/tandem mass spectrometry (LC/MS/MS). Adducts of dGuo and dAdo were detected under selected reaction monitoring in liver and bone marrow 10 h after administration of melphalan. In the DNA hydrolysates from kidney and blood a Gua-melphalan adduct was found, although in very low abundance. These first results of the search for in vivo-formed melphalan adducts in the rat showed that our miniaturized LC/MS technique is useful for investigating this type of compound. More experiments will be performed in this area to gather more information about the pharmacokinetics and the quantity of adducts formed." @default.
- W2145871617 created "2016-06-24" @default.
- W2145871617 creator A5027126298 @default.
- W2145871617 creator A5030928099 @default.
- W2145871617 creator A5040417544 @default.
- W2145871617 creator A5086150021 @default.
- W2145871617 creator A5079179595 @default.
- W2145871617 date "2003-11-25" @default.
- W2145871617 modified "2023-10-10" @default.
- W2145871617 title "Qualitative study ofin vivo melphalan adduct formation in the rat by miniaturized column-switching liquid chromatography coupled with electrospray mass spectrometry" @default.
- W2145871617 cites W1967127679 @default.
- W2145871617 cites W1984984497 @default.
- W2145871617 cites W2003457516 @default.
- W2145871617 cites W2026793707 @default.
- W2145871617 cites W2058844081 @default.
- W2145871617 cites W2060008442 @default.
- W2145871617 cites W2060906448 @default.
- W2145871617 cites W2072479153 @default.
- W2145871617 cites W2087535733 @default.
- W2145871617 cites W2094385987 @default.
- W2145871617 cites W2151275048 @default.
- W2145871617 doi "https://doi.org/10.1002/jms.540" @default.
- W2145871617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14760610" @default.
- W2145871617 hasPublicationYear "2003" @default.
- W2145871617 type Work @default.
- W2145871617 sameAs 2145871617 @default.
- W2145871617 citedByCount "11" @default.
- W2145871617 countsByYear W21458716172013 @default.
- W2145871617 countsByYear W21458716172017 @default.
- W2145871617 countsByYear W21458716172021 @default.
- W2145871617 countsByYear W21458716172022 @default.
- W2145871617 crossrefType "journal-article" @default.
- W2145871617 hasAuthorship W2145871617A5027126298 @default.
- W2145871617 hasAuthorship W2145871617A5030928099 @default.
- W2145871617 hasAuthorship W2145871617A5040417544 @default.
- W2145871617 hasAuthorship W2145871617A5079179595 @default.
- W2145871617 hasAuthorship W2145871617A5086150021 @default.
- W2145871617 hasBestOaLocation W21458716171 @default.
- W2145871617 hasConcept C108204754 @default.
- W2145871617 hasConcept C126322002 @default.
- W2145871617 hasConcept C150903083 @default.
- W2145871617 hasConcept C162356407 @default.
- W2145871617 hasConcept C178790620 @default.
- W2145871617 hasConcept C179998833 @default.
- W2145871617 hasConcept C185592680 @default.
- W2145871617 hasConcept C207001950 @default.
- W2145871617 hasConcept C2778684742 @default.
- W2145871617 hasConcept C2911091166 @default.
- W2145871617 hasConcept C31827203 @default.
- W2145871617 hasConcept C40684141 @default.
- W2145871617 hasConcept C43617362 @default.
- W2145871617 hasConcept C64489805 @default.
- W2145871617 hasConcept C71924100 @default.
- W2145871617 hasConcept C86803240 @default.
- W2145871617 hasConceptScore W2145871617C108204754 @default.
- W2145871617 hasConceptScore W2145871617C126322002 @default.
- W2145871617 hasConceptScore W2145871617C150903083 @default.
- W2145871617 hasConceptScore W2145871617C162356407 @default.
- W2145871617 hasConceptScore W2145871617C178790620 @default.
- W2145871617 hasConceptScore W2145871617C179998833 @default.
- W2145871617 hasConceptScore W2145871617C185592680 @default.
- W2145871617 hasConceptScore W2145871617C207001950 @default.
- W2145871617 hasConceptScore W2145871617C2778684742 @default.
- W2145871617 hasConceptScore W2145871617C2911091166 @default.
- W2145871617 hasConceptScore W2145871617C31827203 @default.
- W2145871617 hasConceptScore W2145871617C40684141 @default.
- W2145871617 hasConceptScore W2145871617C43617362 @default.
- W2145871617 hasConceptScore W2145871617C64489805 @default.
- W2145871617 hasConceptScore W2145871617C71924100 @default.
- W2145871617 hasConceptScore W2145871617C86803240 @default.
- W2145871617 hasIssue "1" @default.
- W2145871617 hasLocation W21458716171 @default.
- W2145871617 hasLocation W21458716172 @default.
- W2145871617 hasOpenAccess W2145871617 @default.
- W2145871617 hasPrimaryLocation W21458716171 @default.
- W2145871617 hasRelatedWork W1983444671 @default.
- W2145871617 hasRelatedWork W1988661674 @default.
- W2145871617 hasRelatedWork W1999397561 @default.
- W2145871617 hasRelatedWork W2000133861 @default.
- W2145871617 hasRelatedWork W2008298182 @default.
- W2145871617 hasRelatedWork W2020902296 @default.
- W2145871617 hasRelatedWork W2022958217 @default.
- W2145871617 hasRelatedWork W2044016383 @default.
- W2145871617 hasRelatedWork W4367600475 @default.
- W2145871617 hasRelatedWork W964154261 @default.
- W2145871617 hasVolume "39" @default.
- W2145871617 isParatext "false" @default.
- W2145871617 isRetracted "false" @default.
- W2145871617 magId "2145871617" @default.
- W2145871617 workType "article" @default.