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• W2145874229 abstract "Objective : Placental corticotropin-releasing factor (CRF) affects myometrial contractility and the secretion of several uterotonins such as prostaglandins (PGs); however, the activity of CRF is counteracted by CRF-binding protein (CRF-BP). At term and pre-term labor, CRF levels in maternal plasma are highest whereas those of CRF-BP are falling, and the cause of this fall is unknown. Thus, in this study, we investigated the effect of PG administration for labor induction on maternal plasma CRF and CRF-BP concentrations. Design : Maternal plasma CRF and CRF-BP levels were assayed before and after (2 h later) induction of labor by intracervical administration of prostaglandin E 2 (PGE 2 ), and at delivery in a group of healthy post-term pregnancies ( n =18). Controls were women at term out of labor ( n =22), who subsequently progressed to deliver a healthy singleton baby. Methods : CRF was measured by two-site immunoradiometric assay, and CRF-BP was assayed by radioimmunoassay. Results : Maternal plasma CRF levels were significantly ( P <0.0001) lower and CRF-BP significantly ( P <0.0005) higher in post-term than in term pregnancies. With respect to induction of labor, 2 mg PGE 2 were sufficient to increase maternal plasma CRF levels at delivery ( P <0.005). While 0.5 mg PGE 2 significantly decreased maternal plasma CRF-BP levels at delivery ( P <0.001), 2.0 mg PGE 2 significantly reduced CRF-BP concentrations both after 2 h ( P <0.05) and at delivery ( P <0.0001). Conclusions : In the light of the well-known stimulation of prostaglandin release by CRF, these data suggest a positive feedback effect of PGE 2 on maternal CRF release during induced labor." @default.
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• W2145874229 date "2007-09-01" @default.
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• W2145874229 title "Maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein (CRF-BP) levels in post-term pregnancy: effect of prostaglandin administration" @default.
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• W2145874229 doi "https://doi.org/10.1530/eje-07-0138" @default.
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