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- W2145874366 abstract "This is the final report of the Phase I Protocol for the initial clinical study of Multiple Dose WR-2721 with radiotherapy (RTOG 80-02). The essential object of the study was to determine the highest dose of WR-2721 that could be given daily for the greatest number of weeks 15 to 30 minutes before conventional radiation treatment schedules. Eighty-four patients were entered into various dose levels. The major and dose-limiting toxicities were emesis, otension and malaise. The latter symptom was characterized by increases weakness, fatigability, and ill-feeling. The maximum tolerated dose (MTD) established by this study is 340 mg/m2 given 4 days a week (excepting Wednesday) for 5 weeks. The drug is delivered intraveneously in 7 minutes. There were no long-term blood chemistry changes. There were no deaths due to the administration of the radioprotector." @default.
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- W2145874366 date "1988-06-01" @default.
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- W2145874366 title "Final report on phase i trial of WR-2721 before protracted fractionated radiation therapy" @default.
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- W2145874366 doi "https://doi.org/10.1016/0360-3016(88)90387-2" @default.
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