FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145875127> ?p ?o ?g. }

• W2145875127 endingPage "1489" @default.
• W2145875127 startingPage "1478" @default.
• W2145875127 abstract "The function of the β-amyloid precursor protein (APP) of Alzheimer's disease is poorly understood. The secreted ectodomain fragment of APP (sAPPα) can be readily cleaved to produce a small N-terminal fragment (N-APP) that contains heparin-binding and metal-binding domains and that has been found to have biological activity. In the present study, we examined whether N-APP can bind to lipids. We found that N-APP binds selectively to phosphoinositides (PIPs) but poorly to most other lipids. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 )-rich microdomains were identified on the extracellular surface of neurons and glia in primary hippocampal cultures. N-APP bound to neurons and colocalized with PIPs on the cell surface. Furthermore, the binding of N-APP to neurons increased the level of cell-surface PI(4,5)P2 and phosphatidylinositol 3,4,5-trisphosphate. However, PIPs were not the principal cell-surface binding site for N-APP, because N-APP binding to neurons was not inhibited by a short-acyl-chain PIP analogue, and N-APP did not bind to glial cells which also possessed PI(4,5)P2 on the cell surface. The data are explained by a model in which N-APP binds to two distinct components on neurons, one of which is an unidentified receptor and the second of which is a PIP lipid, which binds more weakly to a distinct site within N-APP. Our data provide further support for the idea that N-APP may be an important mediator of APP's biological activity." @default.
• W2145875127 created "2016-06-24" @default.
• W2145875127 creator A5026971007 @default.
• W2145875127 creator A5033158652 @default.
• W2145875127 creator A5056348125 @default.
• W2145875127 creator A5058235570 @default.
• W2145875127 creator A5063015733 @default.
• W2145875127 creator A5080376075 @default.
• W2145875127 creator A5080705470 @default.
• W2145875127 creator A5081089760 @default.
• W2145875127 creator A5085815447 @default.
• W2145875127 date "2014-06-11" @default.
• W2145875127 modified "2023-10-05" @default.
• W2145875127 title "The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons" @default.
• W2145875127 cites W1564861448 @default.
• W2145875127 cites W1599737625 @default.
• W2145875127 cites W1600007560 @default.
• W2145875127 cites W1933062072 @default.
• W2145875127 cites W1970491990 @default.
• W2145875127 cites W1972228476 @default.
• W2145875127 cites W1972974751 @default.
• W2145875127 cites W1973238216 @default.
• W2145875127 cites W1977949596 @default.
• W2145875127 cites W1992515094 @default.
• W2145875127 cites W1993011380 @default.
• W2145875127 cites W1995220590 @default.
• W2145875127 cites W2001210466 @default.
• W2145875127 cites W2001445086 @default.
• W2145875127 cites W2009392427 @default.
• W2145875127 cites W2009655341 @default.
• W2145875127 cites W2009994144 @default.
• W2145875127 cites W2029352103 @default.
• W2145875127 cites W2030355018 @default.
• W2145875127 cites W2031848347 @default.
• W2145875127 cites W2035746763 @default.
• W2145875127 cites W2038516967 @default.
• W2145875127 cites W2043312574 @default.
• W2145875127 cites W2045855955 @default.
• W2145875127 cites W2049291815 @default.
• W2145875127 cites W2049539275 @default.
• W2145875127 cites W2054799935 @default.
• W2145875127 cites W2064242629 @default.
• W2145875127 cites W2066346909 @default.
• W2145875127 cites W2067327084 @default.
• W2145875127 cites W2078762085 @default.
• W2145875127 cites W2078854019 @default.
• W2145875127 cites W2090496922 @default.
• W2145875127 cites W2091604559 @default.
• W2145875127 cites W2091884933 @default.
• W2145875127 cites W2105252089 @default.
• W2145875127 cites W2113405903 @default.
• W2145875127 cites W2132695172 @default.
• W2145875127 cites W2136697740 @default.
• W2145875127 cites W2138936877 @default.
• W2145875127 cites W2139944895 @default.
• W2145875127 cites W2140725368 @default.
• W2145875127 cites W2154815136 @default.
• W2145875127 cites W2169924162 @default.
• W2145875127 cites W2320170582 @default.
• W2145875127 doi "https://doi.org/10.1002/jnr.23422" @default.
• W2145875127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24916405" @default.
• W2145875127 hasPublicationYear "2014" @default.
• W2145875127 type Work @default.
• W2145875127 sameAs 2145875127 @default.
• W2145875127 citedByCount "5" @default.
• W2145875127 countsByYear W21458751272016 @default.
• W2145875127 countsByYear W21458751272017 @default.
• W2145875127 countsByYear W21458751272021 @default.
• W2145875127 countsByYear W21458751272023 @default.
• W2145875127 crossrefType "journal-article" @default.
• W2145875127 hasAuthorship W2145875127A5026971007 @default.
• W2145875127 hasAuthorship W2145875127A5033158652 @default.
• W2145875127 hasAuthorship W2145875127A5056348125 @default.
• W2145875127 hasAuthorship W2145875127A5058235570 @default.
• W2145875127 hasAuthorship W2145875127A5063015733 @default.
• W2145875127 hasAuthorship W2145875127A5080376075 @default.
• W2145875127 hasAuthorship W2145875127A5080705470 @default.
• W2145875127 hasAuthorship W2145875127A5081089760 @default.
• W2145875127 hasAuthorship W2145875127A5085815447 @default.
• W2145875127 hasConcept C1009742 @default.
• W2145875127 hasConcept C107824862 @default.
• W2145875127 hasConcept C142724271 @default.
• W2145875127 hasConcept C148762608 @default.
• W2145875127 hasConcept C169760540 @default.
• W2145875127 hasConcept C170493617 @default.
• W2145875127 hasConcept C185592680 @default.
• W2145875127 hasConcept C2779134260 @default.
• W2145875127 hasConcept C2780610907 @default.
• W2145875127 hasConcept C31705614 @default.
• W2145875127 hasConcept C502032728 @default.
• W2145875127 hasConcept C55493867 @default.
• W2145875127 hasConcept C62478195 @default.
• W2145875127 hasConcept C71924100 @default.
• W2145875127 hasConcept C86803240 @default.
• W2145875127 hasConcept C95444343 @default.
• W2145875127 hasConceptScore W2145875127C1009742 @default.
• W2145875127 hasConceptScore W2145875127C107824862 @default.
• W2145875127 hasConceptScore W2145875127C142724271 @default.

• next