Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145883703> ?p ?o ?g. }
- W2145883703 endingPage "86" @default.
- W2145883703 startingPage "76" @default.
- W2145883703 abstract "Spermatogonial stem cells (SSCs) undergo self-renewal division and support spermatogenesis. Although several cytokines coordinate to drive SSC self-renewal, little is known about the mechanisms underlying this process. We investigated the molecular mechanism by reconstructing SSC self-renewal in vitro without exogenous cytokines. Activation of Ras or overexpression of cyclins D2 and E1, both of which were induced by Ras, enabled long-term self-renewal of cultured spermatogonia. SSCs with activated Ras responded properly to differentiation signals and underwent spermatogenesis, whereas differentiation was abrogated in cyclin transfectants after spermatogonial transplantation. Both Ras- and cyclin-transfected cells produced seminomatous tumors, suggesting that excessive self-renewing stimulus induces oncogenic transformation. In contrast, cells that overexpressed cyclin D1 or D3 failed to make germ cell colonies after transplantation, which indicated that cyclin expression pattern is an important determinant to long-term SSC recolonization. Thus, the Ras-cyclin D2 pathway regulates the balance between tissue maintenance and tumorigenesis in the SSC population." @default.
- W2145883703 created "2016-06-24" @default.
- W2145883703 creator A5004195510 @default.
- W2145883703 creator A5004986891 @default.
- W2145883703 creator A5011918761 @default.
- W2145883703 creator A5024139724 @default.
- W2145883703 creator A5025504870 @default.
- W2145883703 creator A5042749895 @default.
- W2145883703 creator A5049283637 @default.
- W2145883703 creator A5080891156 @default.
- W2145883703 date "2009-07-01" @default.
- W2145883703 modified "2023-10-17" @default.
- W2145883703 title "Genetic Reconstruction of Mouse Spermatogonial Stem Cell Self-Renewal In Vitro by Ras-Cyclin D2 Activation" @default.
- W2145883703 cites W1516316082 @default.
- W2145883703 cites W1904981070 @default.
- W2145883703 cites W1965049479 @default.
- W2145883703 cites W1965150594 @default.
- W2145883703 cites W1973839563 @default.
- W2145883703 cites W1999356404 @default.
- W2145883703 cites W2003386645 @default.
- W2145883703 cites W2003473161 @default.
- W2145883703 cites W2009620890 @default.
- W2145883703 cites W2011872034 @default.
- W2145883703 cites W2012820717 @default.
- W2145883703 cites W2016789158 @default.
- W2145883703 cites W2020330574 @default.
- W2145883703 cites W2024159010 @default.
- W2145883703 cites W2028757936 @default.
- W2145883703 cites W2037530508 @default.
- W2145883703 cites W2052465225 @default.
- W2145883703 cites W2067064279 @default.
- W2145883703 cites W2067146341 @default.
- W2145883703 cites W2071749936 @default.
- W2145883703 cites W2081554709 @default.
- W2145883703 cites W2093965961 @default.
- W2145883703 cites W2109682463 @default.
- W2145883703 cites W2131238404 @default.
- W2145883703 cites W2137074443 @default.
- W2145883703 cites W2141924473 @default.
- W2145883703 cites W2147898515 @default.
- W2145883703 cites W2152107294 @default.
- W2145883703 cites W2153416167 @default.
- W2145883703 cites W2155023059 @default.
- W2145883703 cites W2160276016 @default.
- W2145883703 doi "https://doi.org/10.1016/j.stem.2009.04.020" @default.
- W2145883703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19570516" @default.
- W2145883703 hasPublicationYear "2009" @default.
- W2145883703 type Work @default.
- W2145883703 sameAs 2145883703 @default.
- W2145883703 citedByCount "126" @default.
- W2145883703 countsByYear W21458837032012 @default.
- W2145883703 countsByYear W21458837032013 @default.
- W2145883703 countsByYear W21458837032014 @default.
- W2145883703 countsByYear W21458837032015 @default.
- W2145883703 countsByYear W21458837032016 @default.
- W2145883703 countsByYear W21458837032017 @default.
- W2145883703 countsByYear W21458837032018 @default.
- W2145883703 countsByYear W21458837032019 @default.
- W2145883703 countsByYear W21458837032020 @default.
- W2145883703 countsByYear W21458837032021 @default.
- W2145883703 countsByYear W21458837032022 @default.
- W2145883703 countsByYear W21458837032023 @default.
- W2145883703 crossrefType "journal-article" @default.
- W2145883703 hasAuthorship W2145883703A5004195510 @default.
- W2145883703 hasAuthorship W2145883703A5004986891 @default.
- W2145883703 hasAuthorship W2145883703A5011918761 @default.
- W2145883703 hasAuthorship W2145883703A5024139724 @default.
- W2145883703 hasAuthorship W2145883703A5025504870 @default.
- W2145883703 hasAuthorship W2145883703A5042749895 @default.
- W2145883703 hasAuthorship W2145883703A5049283637 @default.
- W2145883703 hasAuthorship W2145883703A5080891156 @default.
- W2145883703 hasBestOaLocation W21458837031 @default.
- W2145883703 hasConcept C104317684 @default.
- W2145883703 hasConcept C11882975 @default.
- W2145883703 hasConcept C120089663 @default.
- W2145883703 hasConcept C120504264 @default.
- W2145883703 hasConcept C123765429 @default.
- W2145883703 hasConcept C126322002 @default.
- W2145883703 hasConcept C134018914 @default.
- W2145883703 hasConcept C144024400 @default.
- W2145883703 hasConcept C1491633281 @default.
- W2145883703 hasConcept C149923435 @default.
- W2145883703 hasConcept C16438837 @default.
- W2145883703 hasConcept C199835354 @default.
- W2145883703 hasConcept C203014093 @default.
- W2145883703 hasConcept C2778437423 @default.
- W2145883703 hasConcept C2780360765 @default.
- W2145883703 hasConcept C28328180 @default.
- W2145883703 hasConcept C2908647359 @default.
- W2145883703 hasConcept C2911091166 @default.
- W2145883703 hasConcept C29537977 @default.
- W2145883703 hasConcept C502942594 @default.
- W2145883703 hasConcept C54009773 @default.
- W2145883703 hasConcept C54355233 @default.
- W2145883703 hasConcept C555283112 @default.
- W2145883703 hasConcept C71924100 @default.
- W2145883703 hasConcept C81885089 @default.
- W2145883703 hasConcept C86803240 @default.