FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145890361> ?p ?o ?g. }

• W2145890361 endingPage "1513" @default.
• W2145890361 startingPage "1505" @default.
• W2145890361 abstract "Reactive oxygen species (ROS) are important signaling molecules in cells. Excessive ROS induce expression of inflammatory mediators, such as iNOS and COX2. Antioxidant enzymes, such as, heme oxygenase-1 (HO-1), tightly regulate ROS levels within cells. Here, we show that Bay 11-7082 (Bay) increased HO-1 mRNA and protein expression in human colon cancer HT29 cells. Bay induced translocation of NF-E2-related factor 2 (Nrf2) into nuclei and increased the binding activity of the antioxidant response element (ARE). In addition, PI3K/Akt inhibitor (LY294002) blocked Bay-induced HO-1 expression. Pretreatment with anti-oxidants (N-acetylcysteine (NAC) or glutathione) significantly reduced Bay-induced HO-1 mRNA/protein expression, nuclear translocation of Nrf2 and phosphorylation of Akt. However, PI3K/Akt signaling was independent of Bay-induced Nrf2 translocation and ARE binding activity. Furthermore, other NF-κB inhibitors, such as pyrrolidine dithiocarbamate (PDTC) and MG132, also increased HO-1 mRNA and protein expression. However, although overexpression of dominant negative inhibitory κB (IκB) reduced NF-κB-driven transcriptional activity, IκB overexpression did not increase HO-1 expression. Taken together, our results suggest that in human colon cancer HT29 cells, Bay induces HO-1 expression by increasing ROS production in an Nrf2–ARE and PI3K dependent manner, but Bay acts independently of NF-κB." @default.
• W2145890361 created "2016-06-24" @default.
• W2145890361 creator A5023771868 @default.
• W2145890361 creator A5040492220 @default.
• W2145890361 creator A5060191269 @default.
• W2145890361 creator A5070789043 @default.
• W2145890361 date "2011-09-01" @default.
• W2145890361 modified "2023-10-02" @default.
• W2145890361 title "An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)–Nrf2–ARE signaling and ROS–PI3K/Akt signaling in an NF-κB-independent mechanism" @default.
• W2145890361 cites W1483926031 @default.
• W2145890361 cites W1529716765 @default.
• W2145890361 cites W1547652970 @default.
• W2145890361 cites W1561096292 @default.
• W2145890361 cites W1591881963 @default.
• W2145890361 cites W1728066272 @default.
• W2145890361 cites W1904705252 @default.
• W2145890361 cites W1966197860 @default.
• W2145890361 cites W1968893973 @default.
• W2145890361 cites W1971428334 @default.
• W2145890361 cites W1973141016 @default.
• W2145890361 cites W1979672764 @default.
• W2145890361 cites W1990283995 @default.
• W2145890361 cites W1991631628 @default.
• W2145890361 cites W1997665579 @default.
• W2145890361 cites W2000495014 @default.
• W2145890361 cites W2000614995 @default.
• W2145890361 cites W2001751920 @default.
• W2145890361 cites W2004041535 @default.
• W2145890361 cites W2004681520 @default.
• W2145890361 cites W2006897495 @default.
• W2145890361 cites W2011313568 @default.
• W2145890361 cites W2013406393 @default.
• W2145890361 cites W2014308014 @default.
• W2145890361 cites W2014616661 @default.
• W2145890361 cites W2018011543 @default.
• W2145890361 cites W2021115145 @default.
• W2145890361 cites W2027149317 @default.
• W2145890361 cites W2028382049 @default.
• W2145890361 cites W2036956805 @default.
• W2145890361 cites W2046074852 @default.
• W2145890361 cites W2053063855 @default.
• W2145890361 cites W2053370093 @default.
• W2145890361 cites W2054056570 @default.
• W2145890361 cites W2054496846 @default.
• W2145890361 cites W2055801667 @default.
• W2145890361 cites W2056523101 @default.
• W2145890361 cites W2057810394 @default.
• W2145890361 cites W2062145087 @default.
• W2145890361 cites W2064647661 @default.
• W2145890361 cites W2080373340 @default.
• W2145890361 cites W2087311397 @default.
• W2145890361 cites W2095467825 @default.
• W2145890361 cites W2101759139 @default.
• W2145890361 cites W2102353091 @default.
• W2145890361 cites W2115338196 @default.
• W2145890361 cites W2124034233 @default.
• W2145890361 cites W2132263242 @default.
• W2145890361 cites W2134498505 @default.
• W2145890361 cites W2142297686 @default.
• W2145890361 cites W2145287139 @default.
• W2145890361 cites W2159567970 @default.
• W2145890361 cites W2331176038 @default.
• W2145890361 doi "https://doi.org/10.1016/j.cellsig.2011.05.013" @default.
• W2145890361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21620964" @default.
• W2145890361 hasPublicationYear "2011" @default.
• W2145890361 type Work @default.
• W2145890361 sameAs 2145890361 @default.
• W2145890361 citedByCount "76" @default.
• W2145890361 countsByYear W21458903612012 @default.
• W2145890361 countsByYear W21458903612013 @default.
• W2145890361 countsByYear W21458903612014 @default.
• W2145890361 countsByYear W21458903612015 @default.
• W2145890361 countsByYear W21458903612016 @default.
• W2145890361 countsByYear W21458903612017 @default.
• W2145890361 countsByYear W21458903612018 @default.
• W2145890361 countsByYear W21458903612019 @default.
• W2145890361 countsByYear W21458903612020 @default.
• W2145890361 countsByYear W21458903612021 @default.
• W2145890361 countsByYear W21458903612022 @default.
• W2145890361 countsByYear W21458903612023 @default.
• W2145890361 crossrefType "journal-article" @default.
• W2145890361 hasAuthorship W2145890361A5023771868 @default.
• W2145890361 hasAuthorship W2145890361A5040492220 @default.
• W2145890361 hasAuthorship W2145890361A5060191269 @default.
• W2145890361 hasAuthorship W2145890361A5070789043 @default.
• W2145890361 hasConcept C11960822 @default.
• W2145890361 hasConcept C153911025 @default.
• W2145890361 hasConcept C181199279 @default.
• W2145890361 hasConcept C185592680 @default.
• W2145890361 hasConcept C190283241 @default.
• W2145890361 hasConcept C2776217839 @default.
• W2145890361 hasConcept C2776912716 @default.
• W2145890361 hasConcept C2777730290 @default.
• W2145890361 hasConcept C2778367456 @default.
• W2145890361 hasConcept C2778506107 @default.
• W2145890361 hasConcept C2779219270 @default.
• W2145890361 hasConcept C2779730028 @default.
• W2145890361 hasConcept C2780983412 @default.

• next