FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145906341> ?p ?o ?g. }

• W2145906341 endingPage "7116" @default.
• W2145906341 startingPage "7108" @default.
• W2145906341 abstract "Glucocorticoids inhibit the proinflammatory activities of transcription factors such as AP-1 and NF-kappa B as well as that of diverse cellular signaling molecules. One of these signaling molecules is the extracellular signal-regulated kinase (Erk-1/2) that controls the release of allergic mediators and the induction of proinflammatory cytokine gene expression in mast cells. The mechanism of inhibition of Erk-1/2 activity by glucocorticoids is unknown. Here we report a novel dual action of glucocorticoids for this inhibition. Glucocorticoids increase the expression of the MAP kinase phosphatase-1 (MKP-1) gene at the promoter level, and attenuate proteasomal degradation of MKP-1, which we report to be triggered by activation of mast cells. Both induction of MKP-1 expression and inhibition of its degradation are necessary for glucocorticoid-mediated inhibition of Erk-1/2 activation. In NIH-3T3 fibroblasts, although glucocorticoids up-regulate the MKP-1 level, they do not attenuate the proteasomal degradation of this protein and consequently they are unable to inhibit Erk-1/2 activity. These results identify MKP-1 as essential for glucocorticoid-mediated control of Erk-1/2 activation and unravel a novel regulatory mechanism for this anti-inflammatory drug." @default.
• W2145906341 created "2016-06-24" @default.
• W2145906341 creator A5029445218 @default.
• W2145906341 creator A5046430456 @default.
• W2145906341 creator A5048269157 @default.
• W2145906341 creator A5048889187 @default.
• W2145906341 creator A5074197659 @default.
• W2145906341 creator A5091509175 @default.
• W2145906341 date "2001-12-17" @default.
• W2145906341 modified "2023-09-29" @default.
• W2145906341 title "Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1" @default.
• W2145906341 cites W14552048 @default.
• W2145906341 cites W1489188266 @default.
• W2145906341 cites W1501356685 @default.
• W2145906341 cites W1503141318 @default.
• W2145906341 cites W1513639374 @default.
• W2145906341 cites W1536913980 @default.
• W2145906341 cites W1551136566 @default.
• W2145906341 cites W1589012667 @default.
• W2145906341 cites W1594319270 @default.
• W2145906341 cites W1597498191 @default.
• W2145906341 cites W1745264954 @default.
• W2145906341 cites W1816680223 @default.
• W2145906341 cites W1972068952 @default.
• W2145906341 cites W1977327723 @default.
• W2145906341 cites W1987183940 @default.
• W2145906341 cites W1992093304 @default.
• W2145906341 cites W1998470358 @default.
• W2145906341 cites W2002334611 @default.
• W2145906341 cites W2003290228 @default.
• W2145906341 cites W2011184703 @default.
• W2145906341 cites W2013612920 @default.
• W2145906341 cites W2033330205 @default.
• W2145906341 cites W2037111992 @default.
• W2145906341 cites W2050252881 @default.
• W2145906341 cites W2051819610 @default.
• W2145906341 cites W2052059014 @default.
• W2145906341 cites W2088571054 @default.
• W2145906341 cites W2106372965 @default.
• W2145906341 cites W2106412710 @default.
• W2145906341 cites W2113252814 @default.
• W2145906341 cites W2115701574 @default.
• W2145906341 cites W2117245487 @default.
• W2145906341 cites W2126836839 @default.
• W2145906341 cites W2134055375 @default.
• W2145906341 cites W2142940299 @default.
• W2145906341 cites W2149097043 @default.
• W2145906341 cites W2160307820 @default.
• W2145906341 cites W2179336653 @default.
• W2145906341 cites W2206511590 @default.
• W2145906341 cites W227580377 @default.
• W2145906341 cites W2288844445 @default.
• W2145906341 cites W2338057898 @default.
• W2145906341 cites W2410483518 @default.
• W2145906341 cites W4256628311 @default.
• W2145906341 cites W6837822 @default.
• W2145906341 doi "https://doi.org/10.1093/emboj/20.24.7108" @default.
• W2145906341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125780" @default.
• W2145906341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11742987" @default.
• W2145906341 hasPublicationYear "2001" @default.
• W2145906341 type Work @default.
• W2145906341 sameAs 2145906341 @default.
• W2145906341 citedByCount "445" @default.
• W2145906341 countsByYear W21459063412012 @default.
• W2145906341 countsByYear W21459063412013 @default.
• W2145906341 countsByYear W21459063412014 @default.
• W2145906341 countsByYear W21459063412015 @default.
• W2145906341 countsByYear W21459063412016 @default.
• W2145906341 countsByYear W21459063412017 @default.
• W2145906341 countsByYear W21459063412018 @default.
• W2145906341 countsByYear W21459063412019 @default.
• W2145906341 countsByYear W21459063412020 @default.
• W2145906341 countsByYear W21459063412021 @default.
• W2145906341 countsByYear W21459063412022 @default.
• W2145906341 countsByYear W21459063412023 @default.
• W2145906341 crossrefType "journal-article" @default.
• W2145906341 hasAuthorship W2145906341A5029445218 @default.
• W2145906341 hasAuthorship W2145906341A5046430456 @default.
• W2145906341 hasAuthorship W2145906341A5048269157 @default.
• W2145906341 hasAuthorship W2145906341A5048889187 @default.
• W2145906341 hasAuthorship W2145906341A5074197659 @default.
• W2145906341 hasAuthorship W2145906341A5091509175 @default.
• W2145906341 hasBestOaLocation W21459063411 @default.
• W2145906341 hasConcept C104317684 @default.
• W2145906341 hasConcept C11960822 @default.
• W2145906341 hasConcept C132149769 @default.
• W2145906341 hasConcept C164027704 @default.
• W2145906341 hasConcept C178666793 @default.
• W2145906341 hasConcept C184235292 @default.
• W2145906341 hasConcept C203014093 @default.
• W2145906341 hasConcept C2776914184 @default.
• W2145906341 hasConcept C2780841215 @default.
• W2145906341 hasConcept C55493867 @default.
• W2145906341 hasConcept C57074206 @default.
• W2145906341 hasConcept C62478195 @default.
• W2145906341 hasConcept C86339819 @default.
• W2145906341 hasConcept C86803240 @default.
• W2145906341 hasConcept C95444343 @default.

• next