Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145970005> ?p ?o ?g. }
- W2145970005 endingPage "368" @default.
- W2145970005 startingPage "357" @default.
- W2145970005 abstract "Small RNA regulatory pathways are used to control the activity of transposons, regulate gene expression and resist infecting viruses. We examined the biogenesis of mRNA-derived endogenous short-interfering RNAs (endo-siRNAs) in the disease vector mosquito Aedes aegypti. Under standard conditions, mRNA-derived endo-siRNAs were produced from the bidirectional transcription of tail−tail overlapping gene pairs. Upon infection with the alphavirus, Sindbis virus (SINV), another class of mRNA-derived endo-siRNAs was observed. Genes producing SINV-induced endo-siRNAs were not enriched for overlapping partners or nearby genes, but were enriched for transcripts with long 3′ untranslated regions. Endo-siRNAs from this class derived uniformly from the entire length of the target transcript, and were found to regulate the transcript levels of the genes from which they were derived. Strand-specific quantitative PCR experiments demonstrated that antisense strands of targeted mRNA genes were produced to exonic, but not intronic regions. Finally, small RNAs mapped to both sense and antisense strands of exon−exon junctions, suggesting double-stranded RNA precursors to SINV-induced endo-siRNAs may be synthesized from mature mRNA templates. These results suggest additional complexity in small RNA pathways and gene regulation in the presence of an infecting virus in disease vector mosquitoes." @default.
- W2145970005 created "2016-06-24" @default.
- W2145970005 creator A5015549381 @default.
- W2145970005 creator A5028277553 @default.
- W2145970005 creator A5069553088 @default.
- W2145970005 creator A5081453356 @default.
- W2145970005 creator A5088503493 @default.
- W2145970005 date "2012-03-27" @default.
- W2145970005 modified "2023-09-24" @default.
- W2145970005 title "Sindbis virus induces the production of a novel class of endogenous siRNAs in Aedes aegypti mosquitoes" @default.
- W2145970005 cites W1932753289 @default.
- W2145970005 cites W1963708619 @default.
- W2145970005 cites W1967884424 @default.
- W2145970005 cites W1976631050 @default.
- W2145970005 cites W1981395994 @default.
- W2145970005 cites W1991007428 @default.
- W2145970005 cites W2003330861 @default.
- W2145970005 cites W2013182015 @default.
- W2145970005 cites W2015595212 @default.
- W2145970005 cites W2027546897 @default.
- W2145970005 cites W2029433700 @default.
- W2145970005 cites W2030551855 @default.
- W2145970005 cites W2033518550 @default.
- W2145970005 cites W2034206562 @default.
- W2145970005 cites W2034245741 @default.
- W2145970005 cites W2034255392 @default.
- W2145970005 cites W2040316830 @default.
- W2145970005 cites W2053850578 @default.
- W2145970005 cites W2056546931 @default.
- W2145970005 cites W2057980082 @default.
- W2145970005 cites W2061741217 @default.
- W2145970005 cites W2094057862 @default.
- W2145970005 cites W2107018762 @default.
- W2145970005 cites W2107330252 @default.
- W2145970005 cites W2112938399 @default.
- W2145970005 cites W2114582526 @default.
- W2145970005 cites W2120805065 @default.
- W2145970005 cites W2123526762 @default.
- W2145970005 cites W2124985265 @default.
- W2145970005 cites W2126573849 @default.
- W2145970005 cites W2130679719 @default.
- W2145970005 cites W2132767295 @default.
- W2145970005 cites W2136373859 @default.
- W2145970005 cites W2139268538 @default.
- W2145970005 cites W2139841087 @default.
- W2145970005 cites W2140001914 @default.
- W2145970005 cites W2141838493 @default.
- W2145970005 cites W2143424128 @default.
- W2145970005 cites W2146516445 @default.
- W2145970005 cites W2155115337 @default.
- W2145970005 cites W2162674498 @default.
- W2145970005 cites W2166832275 @default.
- W2145970005 cites W2171158206 @default.
- W2145970005 cites W336077928 @default.
- W2145970005 doi "https://doi.org/10.1111/j.1365-2583.2012.01141.x" @default.
- W2145970005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3386798" @default.
- W2145970005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22458920" @default.
- W2145970005 hasPublicationYear "2012" @default.
- W2145970005 type Work @default.
- W2145970005 sameAs 2145970005 @default.
- W2145970005 citedByCount "20" @default.
- W2145970005 countsByYear W21459700052012 @default.
- W2145970005 countsByYear W21459700052013 @default.
- W2145970005 countsByYear W21459700052014 @default.
- W2145970005 countsByYear W21459700052015 @default.
- W2145970005 countsByYear W21459700052016 @default.
- W2145970005 countsByYear W21459700052017 @default.
- W2145970005 countsByYear W21459700052020 @default.
- W2145970005 countsByYear W21459700052021 @default.
- W2145970005 countsByYear W21459700052022 @default.
- W2145970005 crossrefType "journal-article" @default.
- W2145970005 hasAuthorship W2145970005A5015549381 @default.
- W2145970005 hasAuthorship W2145970005A5028277553 @default.
- W2145970005 hasAuthorship W2145970005A5069553088 @default.
- W2145970005 hasAuthorship W2145970005A5081453356 @default.
- W2145970005 hasAuthorship W2145970005A5088503493 @default.
- W2145970005 hasBestOaLocation W21459700052 @default.
- W2145970005 hasConcept C104317684 @default.
- W2145970005 hasConcept C105580179 @default.
- W2145970005 hasConcept C150194340 @default.
- W2145970005 hasConcept C153911025 @default.
- W2145970005 hasConcept C166703698 @default.
- W2145970005 hasConcept C173758957 @default.
- W2145970005 hasConcept C202416437 @default.
- W2145970005 hasConcept C2191507 @default.
- W2145970005 hasConcept C22615655 @default.
- W2145970005 hasConcept C2777343345 @default.
- W2145970005 hasConcept C2777775583 @default.
- W2145970005 hasConcept C54355233 @default.
- W2145970005 hasConcept C59822182 @default.
- W2145970005 hasConcept C60723119 @default.
- W2145970005 hasConcept C67705224 @default.
- W2145970005 hasConcept C86803240 @default.
- W2145970005 hasConcept C89604277 @default.
- W2145970005 hasConcept C95444343 @default.
- W2145970005 hasConceptScore W2145970005C104317684 @default.
- W2145970005 hasConceptScore W2145970005C105580179 @default.
- W2145970005 hasConceptScore W2145970005C150194340 @default.