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• W2145990138 endingPage "91" @default.
• W2145990138 startingPage "76" @default.
• W2145990138 abstract "The pattern of affected organs in metastasis is variable depending on the tumor of origin, indicating that intrinsic cancer cell traits, the physical accessibility of target organs, and the composition of host-organ microenvironments are important determinants of distant metastasis. Metastasis is an inefficient process in which few cells succeed at reestablishing a tumor at a distant organ. Organ-specific metastasis involves cancer cell interactions with the host microenvironment, including activation of paracrine cytokine loops, modification of the host cellular composition, and alteration of extracellular matrix structures. Immune cell evasion, association with a supportive niche, and the ability to amplify survival pathways, often achieved through interaction with the stroma, are essential for successful metastatic colonization. The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer-related mortality. Once established, metastasis is devastating, but only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic colonization. We review the metastatic traits that allow cancer cells to colonize distinct organ sites. The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer-related mortality. Once established, metastasis is devastating, but only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic colonization. We review the metastatic traits that allow cancer cells to colonize distinct organ sites." @default.
• W2145990138 created "2016-06-24" @default.
• W2145990138 creator A5055628562 @default.
• W2145990138 creator A5078729702 @default.
• W2145990138 date "2015-09-01" @default.
• W2145990138 modified "2023-10-14" @default.
• W2145990138 title "Surviving at a Distance: Organ-Specific Metastasis" @default.
• W2145990138 cites W118261500 @default.
• W2145990138 cites W1520425169 @default.
• W2145990138 cites W1528349069 @default.
• W2145990138 cites W1572656384 @default.
• W2145990138 cites W1574492943 @default.
• W2145990138 cites W1586903002 @default.
• W2145990138 cites W1593145356 @default.
• W2145990138 cites W1601681275 @default.
• W2145990138 cites W1918975836 @default.
• W2145990138 cites W1942368628 @default.
• W2145990138 cites W1951471355 @default.
• W2145990138 cites W1964081206 @default.
• W2145990138 cites W1965265512 @default.
• W2145990138 cites W1965371218 @default.
• W2145990138 cites W1968572294 @default.
• W2145990138 cites W1969706233 @default.
• W2145990138 cites W1972952928 @default.
• W2145990138 cites W1983701552 @default.
• W2145990138 cites W1984085143 @default.
• W2145990138 cites W1985727076 @default.
• W2145990138 cites W1986471913 @default.
• W2145990138 cites W1991025954 @default.
• W2145990138 cites W1991486724 @default.
• W2145990138 cites W1993322072 @default.
• W2145990138 cites W1993913242 @default.
• W2145990138 cites W1995209724 @default.
• W2145990138 cites W1999018449 @default.
• W2145990138 cites W2001351884 @default.
• W2145990138 cites W2002626138 @default.
• W2145990138 cites W2003213153 @default.
• W2145990138 cites W2003500892 @default.
• W2145990138 cites W2003605266 @default.
• W2145990138 cites W2005334224 @default.
• W2145990138 cites W2006986876 @default.
• W2145990138 cites W2007196889 @default.
• W2145990138 cites W2007897263 @default.
• W2145990138 cites W2008508879 @default.
• W2145990138 cites W2008705653 @default.
• W2145990138 cites W2014260136 @default.
• W2145990138 cites W2015541518 @default.
• W2145990138 cites W2018288777 @default.
• W2145990138 cites W2019214567 @default.
• W2145990138 cites W2021837858 @default.
• W2145990138 cites W2022233074 @default.
• W2145990138 cites W2022488821 @default.
• W2145990138 cites W2023075736 @default.
• W2145990138 cites W2023291646 @default.
• W2145990138 cites W2023560061 @default.
• W2145990138 cites W2023720844 @default.
• W2145990138 cites W2026815880 @default.
• W2145990138 cites W2026993656 @default.
• W2145990138 cites W2027775756 @default.
• W2145990138 cites W2028563292 @default.
• W2145990138 cites W2028904725 @default.
• W2145990138 cites W2029006847 @default.
• W2145990138 cites W2031984295 @default.
• W2145990138 cites W2032050847 @default.
• W2145990138 cites W2033278321 @default.
• W2145990138 cites W2034855589 @default.
• W2145990138 cites W2037489902 @default.
• W2145990138 cites W2043166238 @default.
• W2145990138 cites W2043201642 @default.
• W2145990138 cites W2043664496 @default.
• W2145990138 cites W2043706386 @default.
• W2145990138 cites W2046148841 @default.
• W2145990138 cites W2047149873 @default.
• W2145990138 cites W2050146329 @default.
• W2145990138 cites W2050547995 @default.
• W2145990138 cites W2050603039 @default.
• W2145990138 cites W2051255001 @default.
• W2145990138 cites W2052467200 @default.
• W2145990138 cites W2053970131 @default.
• W2145990138 cites W2054148405 @default.
• W2145990138 cites W2055489437 @default.
• W2145990138 cites W2056933970 @default.
• W2145990138 cites W2057151160 @default.
• W2145990138 cites W2057253189 @default.
• W2145990138 cites W2057841149 @default.
• W2145990138 cites W2058689904 @default.
• W2145990138 cites W2059653502 @default.
• W2145990138 cites W2062265555 @default.
• W2145990138 cites W2062809449 @default.
• W2145990138 cites W2066030073 @default.
• W2145990138 cites W2069053195 @default.
• W2145990138 cites W2071252762 @default.
• W2145990138 cites W2076356973 @default.
• W2145990138 cites W2083019332 @default.
• W2145990138 cites W2086553719 @default.
• W2145990138 cites W2087324367 @default.
• W2145990138 cites W2088556438 @default.
• W2145990138 cites W2088570048 @default.

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