FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145997688> ?p ?o ?g. }

• W2145997688 endingPage "1452" @default.
• W2145997688 startingPage "1443" @default.
• W2145997688 abstract "Persistent MRSA infections are especially relevant to endovascular infections and correlate with suboptimal outcomes. However, the virulence signatures of Staphylococcus aureus that drive such persistence outcomes are not well defined. In the current study, we investigated correlations between accessory gene regulator (agr) activation and the outcome of vancomycin treatment in an experimental model of infective endocarditis (IE) due to MRSA strains with different agr and clonal complex (CC) types.Twelve isolates with the four most common MRSA CC and agr types (CC5-agr II, CC8-agr I, CC30-agr III and CC45-agr I) were evaluated for heterogeneous vancomycin-intermediate S. aureus (hVISA), agr function, agrA and RNAIII transcription, agr locus sequences, virulence and response to vancomycin in the IE model.Early agr RNAIII activation (beginning at 2 h of growth) in parallel with strong δ-haemolysin production correlated with persistent outcomes in the IE model following vancomycin therapy. Importantly, such treatment failures occurred across the range of CC/agr types studied. In addition, these MRSA strains: (i) were vancomycin susceptible in vitro; (ii) were not hVISA or vancomycin tolerant; and (iii) did not evolve hVISA phenotypes or perturbed δ-haemolysin activity in vivo following vancomycin therapy. Moreover, agr locus sequence analyses revealed no common point mutations that correlated with either temporal RNAIII transcription or vancomycin treatment outcomes, encompassing different CC and agr types.These data suggest that temporal agr RNAIII activation and agr functional profiles may be useful biomarkers to predict the in vivo persistence of endovascular MRSA infections despite vancomycin therapy." @default.
• W2145997688 created "2016-06-24" @default.
• W2145997688 creator A5012110262 @default.
• W2145997688 creator A5012131316 @default.
• W2145997688 creator A5015785702 @default.
• W2145997688 creator A5021031438 @default.
• W2145997688 creator A5044485195 @default.
• W2145997688 creator A5048241672 @default.
• W2145997688 creator A5052234232 @default.
• W2145997688 date "2015-01-05" @default.
• W2145997688 modified "2023-09-24" @default.
• W2145997688 title "Early <i>agr</i> activation correlates with vancomycin treatment failure in multi-clonotype MRSA endovascular infections" @default.
• W2145997688 cites W1521568565 @default.
• W2145997688 cites W1546970515 @default.
• W2145997688 cites W1970783326 @default.
• W2145997688 cites W1993262041 @default.
• W2145997688 cites W1997365473 @default.
• W2145997688 cites W2002249283 @default.
• W2145997688 cites W2007451104 @default.
• W2145997688 cites W2018660616 @default.
• W2145997688 cites W2030720453 @default.
• W2145997688 cites W2063323488 @default.
• W2145997688 cites W2065737889 @default.
• W2145997688 cites W2088970163 @default.
• W2145997688 cites W2095809865 @default.
• W2145997688 cites W2098533519 @default.
• W2145997688 cites W2099839947 @default.
• W2145997688 cites W2100126589 @default.
• W2145997688 cites W2104197803 @default.
• W2145997688 cites W2108182044 @default.
• W2145997688 cites W2111070278 @default.
• W2145997688 cites W2111326608 @default.
• W2145997688 cites W2112785877 @default.
• W2145997688 cites W2121348586 @default.
• W2145997688 cites W2121861720 @default.
• W2145997688 cites W2126915534 @default.
• W2145997688 cites W2129062666 @default.
• W2145997688 cites W2136989595 @default.
• W2145997688 cites W2137499186 @default.
• W2145997688 cites W2138370619 @default.
• W2145997688 cites W2144258933 @default.
• W2145997688 cites W2145240901 @default.
• W2145997688 cites W2145778077 @default.
• W2145997688 cites W2145862457 @default.
• W2145997688 cites W2148466715 @default.
• W2145997688 cites W2149457813 @default.
• W2145997688 cites W2149548525 @default.
• W2145997688 cites W2151452450 @default.
• W2145997688 cites W2155397502 @default.
• W2145997688 cites W2157572113 @default.
• W2145997688 cites W2159308620 @default.
• W2145997688 cites W2161537116 @default.
• W2145997688 cites W2162139256 @default.
• W2145997688 cites W2162914433 @default.
• W2145997688 cites W2168783382 @default.
• W2145997688 cites W2169447360 @default.
• W2145997688 cites W2171155970 @default.
• W2145997688 cites W2171436655 @default.
• W2145997688 cites W2478745350 @default.
• W2145997688 doi "https://doi.org/10.1093/jac/dku547" @default.
• W2145997688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4398469" @default.
• W2145997688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25564565" @default.
• W2145997688 hasPublicationYear "2015" @default.
• W2145997688 type Work @default.
• W2145997688 sameAs 2145997688 @default.
• W2145997688 citedByCount "22" @default.
• W2145997688 countsByYear W21459976882015 @default.
• W2145997688 countsByYear W21459976882016 @default.
• W2145997688 countsByYear W21459976882018 @default.
• W2145997688 countsByYear W21459976882019 @default.
• W2145997688 countsByYear W21459976882020 @default.
• W2145997688 countsByYear W21459976882021 @default.
• W2145997688 countsByYear W21459976882022 @default.
• W2145997688 countsByYear W21459976882023 @default.
• W2145997688 crossrefType "journal-article" @default.
• W2145997688 hasAuthorship W2145997688A5012110262 @default.
• W2145997688 hasAuthorship W2145997688A5012131316 @default.
• W2145997688 hasAuthorship W2145997688A5015785702 @default.
• W2145997688 hasAuthorship W2145997688A5021031438 @default.
• W2145997688 hasAuthorship W2145997688A5044485195 @default.
• W2145997688 hasAuthorship W2145997688A5048241672 @default.
• W2145997688 hasAuthorship W2145997688A5052234232 @default.
• W2145997688 hasBestOaLocation W21459976881 @default.
• W2145997688 hasConcept C104317684 @default.
• W2145997688 hasConcept C2777052132 @default.
• W2145997688 hasConcept C2777334864 @default.
• W2145997688 hasConcept C2777859817 @default.
• W2145997688 hasConcept C2778980435 @default.
• W2145997688 hasConcept C2779489039 @default.
• W2145997688 hasConcept C523546767 @default.
• W2145997688 hasConcept C54355233 @default.
• W2145997688 hasConcept C60987743 @default.
• W2145997688 hasConcept C71924100 @default.
• W2145997688 hasConcept C86803240 @default.
• W2145997688 hasConcept C89423630 @default.
• W2145997688 hasConceptScore W2145997688C104317684 @default.
• W2145997688 hasConceptScore W2145997688C2777052132 @default.
• W2145997688 hasConceptScore W2145997688C2777334864 @default.

• next