FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146011900> ?p ?o ?g. }

• W2146011900 endingPage "2008" @default.
• W2146011900 startingPage "1995" @default.
• W2146011900 abstract "We have previously found that hypoxia stimulates proliferation of vascular fibroblasts through Gαi-mediated activation of ERK1/2. Here, we demonstrate that hypoxia also activates the atypical protein kinase Cζ (PKCζ) isozyme and stimulates the expression of ERK1/2-specific phosphatase, MAP kinase phosphatase-1 (MKP-1), which attenuates ERK1/2-mediated proliferative signals. Replication repressor activity is unique to PKCζ because the blockade of classical and novel PKC isozymes does not affect fibroblast proliferation. PKCζ is phosphorylated upon prolonged (24 h) exposure to hypoxia, whereas ERK1/2, the downstream kinases, are maximally activated in fibroblasts exposed to acute (10 min) hypoxia. However, PKCζ blockade results in persistent ERK1/2 phosphorylation and marked increase in hypoxia-induced replication. Similarly prolonged ERK1/2 phosphorylation and increase in hypoxia-stimulated proliferation are also observed upon blockade of MKP-1 activation. Because of the parallel suppressive actions of PKCζ and MKP-1 on ERK1/2 phosphorylation and proliferation, the role of PKCζ in the regulation of MKP-1 expression was evaluated. PKCζ attenuation reduces MKP-1 expression, whereas PKCζ overexpression increases MKP-1 levels. In conclusion, our results indicate for the first time that hypoxia activates PKCζ, which acts as a terminator of ERK1/2 activation through the regulation of downstream target, MKP-1 expression and thus serves to limit hypoxia-induced proliferation of fibroblasts." @default.
• W2146011900 created "2016-06-24" @default.
• W2146011900 creator A5014076592 @default.
• W2146011900 creator A5019862681 @default.
• W2146011900 creator A5041848420 @default.
• W2146011900 creator A5054661306 @default.
• W2146011900 creator A5073079042 @default.
• W2146011900 date "2006-04-01" @default.
• W2146011900 modified "2023-10-15" @default.
• W2146011900 title "Protein Kinase Cζ Attenuates Hypoxia-induced Proliferation of Fibroblasts by Regulating MAP Kinase Phosphatase-1 Expression" @default.
• W2146011900 cites W148785554 @default.
• W2146011900 cites W1499613770 @default.
• W2146011900 cites W1583472519 @default.
• W2146011900 cites W1763857051 @default.
• W2146011900 cites W1796786705 @default.
• W2146011900 cites W1829394502 @default.
• W2146011900 cites W1869577220 @default.
• W2146011900 cites W1961354364 @default.
• W2146011900 cites W1967737207 @default.
• W2146011900 cites W1973378961 @default.
• W2146011900 cites W1973724353 @default.
• W2146011900 cites W1975438596 @default.
• W2146011900 cites W1979004076 @default.
• W2146011900 cites W1981023296 @default.
• W2146011900 cites W1983426248 @default.
• W2146011900 cites W2000957931 @default.
• W2146011900 cites W2004639056 @default.
• W2146011900 cites W2005823318 @default.
• W2146011900 cites W2006336633 @default.
• W2146011900 cites W2009556803 @default.
• W2146011900 cites W2010434068 @default.
• W2146011900 cites W2011245371 @default.
• W2146011900 cites W2012124753 @default.
• W2146011900 cites W2016168978 @default.
• W2146011900 cites W2020525682 @default.
• W2146011900 cites W2020641276 @default.
• W2146011900 cites W2022557698 @default.
• W2146011900 cites W2023412671 @default.
• W2146011900 cites W2037616743 @default.
• W2146011900 cites W2040098237 @default.
• W2146011900 cites W2054139370 @default.
• W2146011900 cites W2058565137 @default.
• W2146011900 cites W2067807708 @default.
• W2146011900 cites W2071695311 @default.
• W2146011900 cites W2074358810 @default.
• W2146011900 cites W2076273085 @default.
• W2146011900 cites W2082209194 @default.
• W2146011900 cites W2086524338 @default.
• W2146011900 cites W2087965346 @default.
• W2146011900 cites W2092663627 @default.
• W2146011900 cites W2099985438 @default.
• W2146011900 cites W2100233791 @default.
• W2146011900 cites W2100774604 @default.
• W2146011900 cites W2101892902 @default.
• W2146011900 cites W2103019593 @default.
• W2146011900 cites W2106802984 @default.
• W2146011900 cites W2108576089 @default.
• W2146011900 cites W2117245487 @default.
• W2146011900 cites W2123213425 @default.
• W2146011900 cites W2125101968 @default.
• W2146011900 cites W2130040517 @default.
• W2146011900 cites W2146989813 @default.
• W2146011900 cites W2149166688 @default.
• W2146011900 cites W2149887676 @default.
• W2146011900 cites W2161654505 @default.
• W2146011900 cites W2166431337 @default.
• W2146011900 cites W2166844811 @default.
• W2146011900 cites W2264216940 @default.
• W2146011900 cites W2425550511 @default.
• W2146011900 cites W246336561 @default.
• W2146011900 cites W4244047933 @default.
• W2146011900 cites W4246849790 @default.
• W2146011900 cites W93019692 @default.
• W2146011900 doi "https://doi.org/10.1091/mbc.e05-09-0869" @default.
• W2146011900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415328" @default.
• W2146011900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16467381" @default.
• W2146011900 hasPublicationYear "2006" @default.
• W2146011900 type Work @default.
• W2146011900 sameAs 2146011900 @default.
• W2146011900 citedByCount "29" @default.
• W2146011900 countsByYear W21460119002012 @default.
• W2146011900 countsByYear W21460119002013 @default.
• W2146011900 countsByYear W21460119002014 @default.
• W2146011900 countsByYear W21460119002015 @default.
• W2146011900 countsByYear W21460119002016 @default.
• W2146011900 countsByYear W21460119002019 @default.
• W2146011900 countsByYear W21460119002021 @default.
• W2146011900 crossrefType "journal-article" @default.
• W2146011900 hasAuthorship W2146011900A5014076592 @default.
• W2146011900 hasAuthorship W2146011900A5019862681 @default.
• W2146011900 hasAuthorship W2146011900A5041848420 @default.
• W2146011900 hasAuthorship W2146011900A5054661306 @default.
• W2146011900 hasAuthorship W2146011900A5073079042 @default.
• W2146011900 hasBestOaLocation W21460119002 @default.
• W2146011900 hasConcept C11960822 @default.
• W2146011900 hasConcept C132149769 @default.
• W2146011900 hasConcept C153911025 @default.
• W2146011900 hasConcept C178666793 @default.

• next