FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146014169> ?p ?o ?g. }

• W2146014169 endingPage "164" @default.
• W2146014169 startingPage "159" @default.
• W2146014169 abstract "Gene expression signatures have been identified for epithelial ovarian cancer survival (TCGA) and intrinsic subtypes (Tothill et al.). One obstacle to clinical translation is that these signatures were developed using frozen tissue, whereas usually only formalin-fixed, paraffin embedded (FFPE) tissue is available. The aim of this study was to determine if gene expression signatures can be translated to fixed archival tissues.RNA extracted from FFPE sections from 240 primary ovarian cancers was analyzed by DASL on Illumina BeadChip arrays. Concordance of expression at the individual gene level was assessed by comparing array data from the same cancers (30 frozen samples analyzed on Affymetrix arrays versus FFPE DASL).The correlation between FFPE and frozen survival signature estimates was 0.774. The TCGA signature using DASL was predictive of survival in 106 advanced stage high grade serous ovarian cancers (median survival 33 versus 60 months, estimated hazard ratio for death 2.30, P=0.0007). Similar to Tothill, we found using DASL that most high grade serous ovarian cancers (102/110, 93%) were assigned to subtypes 1, 2, 4 and 5, whereas most endometrioid, clear cell, mucinous and low grade serous cases (39/57, 68%) were assigned to subtypes 3 and 6 (P<10e-15).Although individual probe estimates of microarrays may be weakly correlated between FFPE and frozen samples, combinations of probes have robust ability to predict survival and subtype. This suggests that it may be possible to use these signatures for prognostic and predictive purposes as we seek to individualize the treatment of ovarian cancer." @default.
• W2146014169 created "2016-06-24" @default.
• W2146014169 creator A5032566475 @default.
• W2146014169 creator A5038248146 @default.
• W2146014169 creator A5040164008 @default.
• W2146014169 creator A5046539068 @default.
• W2146014169 creator A5056466210 @default.
• W2146014169 creator A5063929778 @default.
• W2146014169 creator A5088726636 @default.
• W2146014169 creator A5090661408 @default.
• W2146014169 date "2013-04-01" @default.
• W2146014169 modified "2023-09-23" @default.
• W2146014169 title "Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues" @default.
• W2146014169 cites W2009671859 @default.
• W2146014169 cites W2025584428 @default.
• W2146014169 cites W2026292458 @default.
• W2146014169 cites W2075229762 @default.
• W2146014169 cites W2079849392 @default.
• W2146014169 cites W2115596977 @default.
• W2146014169 cites W2117058881 @default.
• W2146014169 cites W2117839432 @default.
• W2146014169 cites W2118373398 @default.
• W2146014169 cites W2118782378 @default.
• W2146014169 cites W2123696077 @default.
• W2146014169 cites W2128160790 @default.
• W2146014169 cites W2131593373 @default.
• W2146014169 cites W2146535457 @default.
• W2146014169 cites W2152494192 @default.
• W2146014169 cites W2167736999 @default.
• W2146014169 cites W2170468505 @default.
• W2146014169 cites W2170989872 @default.
• W2146014169 cites W2171530407 @default.
• W2146014169 doi "https://doi.org/10.1016/j.ygyno.2012.12.030" @default.
• W2146014169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3733243" @default.
• W2146014169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23274563" @default.
• W2146014169 hasPublicationYear "2013" @default.
• W2146014169 type Work @default.
• W2146014169 sameAs 2146014169 @default.
• W2146014169 citedByCount "23" @default.
• W2146014169 countsByYear W21460141692013 @default.
• W2146014169 countsByYear W21460141692014 @default.
• W2146014169 countsByYear W21460141692015 @default.
• W2146014169 countsByYear W21460141692016 @default.
• W2146014169 countsByYear W21460141692017 @default.
• W2146014169 countsByYear W21460141692019 @default.
• W2146014169 countsByYear W21460141692020 @default.
• W2146014169 countsByYear W21460141692022 @default.
• W2146014169 crossrefType "journal-article" @default.
• W2146014169 hasAuthorship W2146014169A5032566475 @default.
• W2146014169 hasAuthorship W2146014169A5038248146 @default.
• W2146014169 hasAuthorship W2146014169A5040164008 @default.
• W2146014169 hasAuthorship W2146014169A5046539068 @default.
• W2146014169 hasAuthorship W2146014169A5056466210 @default.
• W2146014169 hasAuthorship W2146014169A5063929778 @default.
• W2146014169 hasAuthorship W2146014169A5088726636 @default.
• W2146014169 hasAuthorship W2146014169A5090661408 @default.
• W2146014169 hasBestOaLocation W21460141692 @default.
• W2146014169 hasConcept C104317684 @default.
• W2146014169 hasConcept C10515644 @default.
• W2146014169 hasConcept C121608353 @default.
• W2146014169 hasConcept C126322002 @default.
• W2146014169 hasConcept C142724271 @default.
• W2146014169 hasConcept C143998085 @default.
• W2146014169 hasConcept C150173356 @default.
• W2146014169 hasConcept C150194340 @default.
• W2146014169 hasConcept C160798450 @default.
• W2146014169 hasConcept C193270364 @default.
• W2146014169 hasConcept C204232928 @default.
• W2146014169 hasConcept C207103383 @default.
• W2146014169 hasConcept C2780427987 @default.
• W2146014169 hasConcept C2993684365 @default.
• W2146014169 hasConcept C44249647 @default.
• W2146014169 hasConcept C502942594 @default.
• W2146014169 hasConcept C54355233 @default.
• W2146014169 hasConcept C71924100 @default.
• W2146014169 hasConcept C86803240 @default.
• W2146014169 hasConceptScore W2146014169C104317684 @default.
• W2146014169 hasConceptScore W2146014169C10515644 @default.
• W2146014169 hasConceptScore W2146014169C121608353 @default.
• W2146014169 hasConceptScore W2146014169C126322002 @default.
• W2146014169 hasConceptScore W2146014169C142724271 @default.
• W2146014169 hasConceptScore W2146014169C143998085 @default.
• W2146014169 hasConceptScore W2146014169C150173356 @default.
• W2146014169 hasConceptScore W2146014169C150194340 @default.
• W2146014169 hasConceptScore W2146014169C160798450 @default.
• W2146014169 hasConceptScore W2146014169C193270364 @default.
• W2146014169 hasConceptScore W2146014169C204232928 @default.
• W2146014169 hasConceptScore W2146014169C207103383 @default.
• W2146014169 hasConceptScore W2146014169C2780427987 @default.
• W2146014169 hasConceptScore W2146014169C2993684365 @default.
• W2146014169 hasConceptScore W2146014169C44249647 @default.
• W2146014169 hasConceptScore W2146014169C502942594 @default.
• W2146014169 hasConceptScore W2146014169C54355233 @default.
• W2146014169 hasConceptScore W2146014169C71924100 @default.
• W2146014169 hasConceptScore W2146014169C86803240 @default.
• W2146014169 hasIssue "1" @default.
• W2146014169 hasLocation W21460141691 @default.
• W2146014169 hasLocation W21460141692 @default.

• next