FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146021974> ?p ?o ?g. }

• W2146021974 endingPage "6425" @default.
• W2146021974 startingPage "6413" @default.
• W2146021974 abstract "DEAD box proteins are a family of putative RNA helicases associated with all aspects of cellular metabolism involving the modification of RNA secondary structure. DDX1 is a member of the DEAD box protein family that is overexpressed in a subset of retinoblastoma and neuroblastoma cell lines and tumors. DDX1 is found primarily in the nucleus, where it forms two to four large aggregates called DDX1 bodies. Here, we report a rapid redistribution of DDX1 in cells exposed to ionizing radiation, resulting in the formation of numerous foci that colocalize with gamma-H2AX and phosphorylated ATM foci at sites of DNA double-strand breaks (DSBs). The formation of DDX1 ionizing-radiation-induced foci (IRIF) is dependent on ATM, which was shown to phosphorylate DDX1 both in vitro and in vivo. The treatment of cells with RNase H prevented the formation of DDX1 IRIF, suggesting that DDX1 is recruited to sites of DNA damage containing RNA-DNA structures. We have shown that DDX1 has RNase activity toward single-stranded RNA, as well as ADP-dependent RNA-DNA- and RNA-RNA-unwinding activities. We propose that DDX1 plays an RNA clearance role at DSB sites, thereby facilitating the template-guided repair of transcriptionally active regions of the genome." @default.
• W2146021974 created "2016-06-24" @default.
• W2146021974 creator A5002242870 @default.
• W2146021974 creator A5062216090 @default.
• W2146021974 creator A5075889094 @default.
• W2146021974 date "2008-10-01" @default.
• W2146021974 modified "2023-10-11" @default.
• W2146021974 title "A Role for DEAD Box 1 at DNA Double-Strand Breaks" @default.
• W2146021974 cites W1499723523 @default.
• W2146021974 cites W1515564094 @default.
• W2146021974 cites W1529048149 @default.
• W2146021974 cites W1564224574 @default.
• W2146021974 cites W1964099889 @default.
• W2146021974 cites W1964622938 @default.
• W2146021974 cites W1983213855 @default.
• W2146021974 cites W1984688123 @default.
• W2146021974 cites W1985233638 @default.
• W2146021974 cites W1993374643 @default.
• W2146021974 cites W2000206408 @default.
• W2146021974 cites W2001222065 @default.
• W2146021974 cites W2015105221 @default.
• W2146021974 cites W2020151423 @default.
• W2146021974 cites W2021150690 @default.
• W2146021974 cites W2022193493 @default.
• W2146021974 cites W2022811243 @default.
• W2146021974 cites W2035659472 @default.
• W2146021974 cites W2035692319 @default.
• W2146021974 cites W2038211069 @default.
• W2146021974 cites W2041542109 @default.
• W2146021974 cites W2044874191 @default.
• W2146021974 cites W2045164156 @default.
• W2146021974 cites W2046723353 @default.
• W2146021974 cites W2049252087 @default.
• W2146021974 cites W2054017160 @default.
• W2146021974 cites W2057949133 @default.
• W2146021974 cites W2059728548 @default.
• W2146021974 cites W2061060103 @default.
• W2146021974 cites W2062232773 @default.
• W2146021974 cites W2070686658 @default.
• W2146021974 cites W2071924188 @default.
• W2146021974 cites W2074615071 @default.
• W2146021974 cites W2079163616 @default.
• W2146021974 cites W2082210185 @default.
• W2146021974 cites W2082810375 @default.
• W2146021974 cites W2082912847 @default.
• W2146021974 cites W2084089807 @default.
• W2146021974 cites W2084969545 @default.
• W2146021974 cites W2089574530 @default.
• W2146021974 cites W2103609416 @default.
• W2146021974 cites W2105495356 @default.
• W2146021974 cites W2109110896 @default.
• W2146021974 cites W2110817748 @default.
• W2146021974 cites W2114084606 @default.
• W2146021974 cites W2116764585 @default.
• W2146021974 cites W2124815451 @default.
• W2146021974 cites W2126595251 @default.
• W2146021974 cites W2134365342 @default.
• W2146021974 cites W2137613124 @default.
• W2146021974 cites W2138165292 @default.
• W2146021974 cites W2138364237 @default.
• W2146021974 cites W2140468862 @default.
• W2146021974 cites W2143629217 @default.
• W2146021974 cites W2147054306 @default.
• W2146021974 cites W2150694543 @default.
• W2146021974 cites W2157497892 @default.
• W2146021974 cites W2159114416 @default.
• W2146021974 cites W2172192445 @default.
• W2146021974 cites W4212962560 @default.
• W2146021974 cites W4229858040 @default.
• W2146021974 cites W4235416064 @default.
• W2146021974 doi "https://doi.org/10.1128/mcb.01053-08" @default.
• W2146021974 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2577411" @default.
• W2146021974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18710941" @default.
• W2146021974 hasPublicationYear "2008" @default.
• W2146021974 type Work @default.
• W2146021974 sameAs 2146021974 @default.
• W2146021974 citedByCount "82" @default.
• W2146021974 countsByYear W21460219742012 @default.
• W2146021974 countsByYear W21460219742013 @default.
• W2146021974 countsByYear W21460219742014 @default.
• W2146021974 countsByYear W21460219742015 @default.
• W2146021974 countsByYear W21460219742016 @default.
• W2146021974 countsByYear W21460219742017 @default.
• W2146021974 countsByYear W21460219742018 @default.
• W2146021974 countsByYear W21460219742019 @default.
• W2146021974 countsByYear W21460219742020 @default.
• W2146021974 countsByYear W21460219742021 @default.
• W2146021974 countsByYear W21460219742022 @default.
• W2146021974 countsByYear W21460219742023 @default.
• W2146021974 crossrefType "journal-article" @default.
• W2146021974 hasAuthorship W2146021974A5002242870 @default.
• W2146021974 hasAuthorship W2146021974A5062216090 @default.
• W2146021974 hasAuthorship W2146021974A5075889094 @default.
• W2146021974 hasBestOaLocation W21460219742 @default.
• W2146021974 hasConcept C104317684 @default.
• W2146021974 hasConcept C10879258 @default.
• W2146021974 hasConcept C143425029 @default.
• W2146021974 hasConcept C153911025 @default.

• next