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• W2146022572 endingPage "12718" @default.
• W2146022572 startingPage "12713" @default.
• W2146022572 abstract "To study RAG2 gene regulation in vivo, we developed a blastocyst complementation method in which RAG2-deficient embryonic stem cells were transfected with genomic clones containing RAG2 and then assessed for their ability to generate lymphocytes. A RAG2 genomic clone that contained only the RAG2 promoter sequences rescued V(D)J recombination in RAG2-deficient pro-B cell lines, but did not rescue development of RAG2-deficient lymphocytes in vivo. However, inclusion of varying lengths of sequences 5' of the RAG2 promoter generated constructs capable of rescuing only in vivo B cell development, as well as other constructs that rescued both B and T cell development. In particular, the 2-kb 5' region starting just upstream of the RAG2 promoter, as well as the region from 2-7 kb 5', could independently drive B cell development, but not efficient T cell development. Deletion of the 2-kb 5' region from the murine germ line demonstrated that this region was not required for RAG expression sufficient to generate normal B or T cell numbers, implying redundancy among 5' elements. We conclude that RAG2 expression in vivo requires elements beyond the core promoter, that such elements contribute to differential regulation in the B vs. T lineages, and that sequences sufficient to direct B cell expression are located in the promoter-proximal 5' region." @default.
• W2146022572 created "2016-06-24" @default.
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• W2146022572 date "1999-10-26" @default.
• W2146022572 modified "2023-10-13" @default.
• W2146022572 title "<i>RAG2</i>is regulated differentially in B and T cells by elements 5′ of the promoter" @default.
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• W2146022572 doi "https://doi.org/10.1073/pnas.96.22.12713" @default.
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