FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146038212> ?p ?o ?g. }

• W2146038212 endingPage "802" @default.
• W2146038212 startingPage "792" @default.
• W2146038212 abstract "Abstract In this article, we discuss the application of the Gaussian process (GP) and other statistical methods (PLS, ANN, and SVM) for the modeling and prediction of binding affinities between the human amphiphysin SH3 domain and its peptide ligands. Divided physicochemical property scores of amino acids, involving significant hydrogen bond, electronic, hydrophobic, and steric properties, was used to characterize the peptide structures, and quantitative structure‐affinity relationship models were then constructed by PLS, ANN, SVM, and GP coupled with genetic algorithm‐variable selection. The results show that: (i) since the significant flexibility and high complexity possessed in polypeptide structures, linear PLS method was incapable of fulfilling a satisfying behavior on SH3 domain binding peptide dataset; (ii) the overfitting involved in training process has decreased the predictive power of ANN model to some extent; (iii) both SVM and GP have a good performance for SH3 domain binding peptide dataset. Moreover, by combining linear and nonlinear terms in the covariance function, the GP is capable of handling linear and nonlinear‐hybrid relationship, and which thus obtained a more stable and predictable model than SVM. Analyses of GP models showed that diversified properties contribute remarkable effect to the interactions between the SH3 domain and the peptides. Particularly, steric property and hydrophobicity of P 2 , electronic property of P 0 , and electronic property and hydrogen bond property of P −3 in decapeptide (P 4 P 3 P 2 P 1 P 0 P −1 P −2 P −3 P −4 P −5 ) significantly contribute to the binding affinities of SH3 domain‐peptide interactions. © 2008 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90:792‐802, 2008. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com" @default.
• W2146038212 created "2016-06-24" @default.
• W2146038212 creator A5023883613 @default.
• W2146038212 creator A5031450974 @default.
• W2146038212 creator A5074703170 @default.
• W2146038212 creator A5080909831 @default.
• W2146038212 date "2008-01-01" @default.
• W2146038212 modified "2023-10-15" @default.
• W2146038212 title "Modeling and prediction of binding affinities between the human amphiphysin SH3 domain and its peptide ligands using genetic algorithm-Gaussian processes" @default.
• W2146038212 cites W1498436455 @default.
• W2146038212 cites W1967042264 @default.
• W2146038212 cites W1967793880 @default.
• W2146038212 cites W1971769921 @default.
• W2146038212 cites W1974156712 @default.
• W2146038212 cites W1981321643 @default.
• W2146038212 cites W1981451479 @default.
• W2146038212 cites W1982915083 @default.
• W2146038212 cites W1988849934 @default.
• W2146038212 cites W1990119892 @default.
• W2146038212 cites W1990516841 @default.
• W2146038212 cites W1997803213 @default.
• W2146038212 cites W2014731953 @default.
• W2146038212 cites W2014851363 @default.
• W2146038212 cites W2018954741 @default.
• W2146038212 cites W2021945571 @default.
• W2146038212 cites W2023306209 @default.
• W2146038212 cites W2024213882 @default.
• W2146038212 cites W2024272753 @default.
• W2146038212 cites W2031772330 @default.
• W2146038212 cites W2037306524 @default.
• W2146038212 cites W2056097559 @default.
• W2146038212 cites W2056189051 @default.
• W2146038212 cites W2057975573 @default.
• W2146038212 cites W2074681440 @default.
• W2146038212 cites W2082640612 @default.
• W2146038212 cites W2085108537 @default.
• W2146038212 cites W2087661061 @default.
• W2146038212 cites W2088032561 @default.
• W2146038212 cites W2107532817 @default.
• W2146038212 cites W2111397525 @default.
• W2146038212 cites W2118689184 @default.
• W2146038212 cites W2119349031 @default.
• W2146038212 cites W2120126891 @default.
• W2146038212 cites W2129386377 @default.
• W2146038212 cites W2137104501 @default.
• W2146038212 cites W2158863190 @default.
• W2146038212 cites W2172167718 @default.
• W2146038212 cites W4239510810 @default.
• W2146038212 cites W62276193 @default.
• W2146038212 doi "https://doi.org/10.1002/bip.21091" @default.
• W2146038212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18814309" @default.
• W2146038212 hasPublicationYear "2008" @default.
• W2146038212 type Work @default.
• W2146038212 sameAs 2146038212 @default.
• W2146038212 citedByCount "57" @default.
• W2146038212 countsByYear W21460382122012 @default.
• W2146038212 countsByYear W21460382122013 @default.
• W2146038212 countsByYear W21460382122014 @default.
• W2146038212 countsByYear W21460382122016 @default.
• W2146038212 countsByYear W21460382122017 @default.
• W2146038212 countsByYear W21460382122018 @default.
• W2146038212 countsByYear W21460382122019 @default.
• W2146038212 countsByYear W21460382122020 @default.
• W2146038212 countsByYear W21460382122021 @default.
• W2146038212 countsByYear W21460382122022 @default.
• W2146038212 crossrefType "journal-article" @default.
• W2146038212 hasAuthorship W2146038212A5023883613 @default.
• W2146038212 hasAuthorship W2146038212A5031450974 @default.
• W2146038212 hasAuthorship W2146038212A5074703170 @default.
• W2146038212 hasAuthorship W2146038212A5080909831 @default.
• W2146038212 hasConcept C108636557 @default.
• W2146038212 hasConcept C112887158 @default.
• W2146038212 hasConcept C11413529 @default.
• W2146038212 hasConcept C119857082 @default.
• W2146038212 hasConcept C12267149 @default.
• W2146038212 hasConcept C147597530 @default.
• W2146038212 hasConcept C154945302 @default.
• W2146038212 hasConcept C163716315 @default.
• W2146038212 hasConcept C170493617 @default.
• W2146038212 hasConcept C178790620 @default.
• W2146038212 hasConcept C185592680 @default.
• W2146038212 hasConcept C196347352 @default.
• W2146038212 hasConcept C201194858 @default.
• W2146038212 hasConcept C2779281246 @default.
• W2146038212 hasConcept C2780283098 @default.
• W2146038212 hasConcept C3018795828 @default.
• W2146038212 hasConcept C32909587 @default.
• W2146038212 hasConcept C33923547 @default.
• W2146038212 hasConcept C41008148 @default.
• W2146038212 hasConcept C55493867 @default.
• W2146038212 hasConcept C70721500 @default.
• W2146038212 hasConcept C71240020 @default.
• W2146038212 hasConcept C86803240 @default.
• W2146038212 hasConceptScore W2146038212C108636557 @default.
• W2146038212 hasConceptScore W2146038212C112887158 @default.
• W2146038212 hasConceptScore W2146038212C11413529 @default.
• W2146038212 hasConceptScore W2146038212C119857082 @default.
• W2146038212 hasConceptScore W2146038212C12267149 @default.

• next