Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146038779> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2146038779 endingPage "71" @default.
- W2146038779 startingPage "1767" @default.
- W2146038779 abstract "The p73 gene located at 1p36.3 encodes for a protein with significant similarity to p53. To investigate the penetrance of p73 in gastric carcinogenesis, we analyzed the expression, allelotype, and mutation of p73 in five cell lines and 75 tissues. Although extremely low levels of p73 expression were observed in all noncancerous gastric tissues and four of five cell lines, a significant elevation of p73 was detected in 37 of 39 (94.9%) carcinoma tissues. Furthermore, a tumor-specific increase of p73 was identified in 14 of 16 (87.5%) matched sets. Allelotyping analysis using a StyI or BanI polymorphism revealed that 5 of 21 (23.8%) informative carcinomas, but none of 19 noncancerous cases, express p73 biallelically, suggesting the transcriptional activation of a silent allele in a subset of cancers. Whereas the transcription of an active allele was markedly induced by serum starvation or clump formation of the cells, treatment with 5-aza-2'deoxycytidine activated a silent allele with a subsequent up-regulation of an active allele, supporting the genomic imprinting and autoregulation of the gene. Allelic deletion or mutation of the gene was not found, and no association of p73 expression with the mutational status of p53 or expression of p21Waf1 was recognized. Taken together, this study argues that p73 is not a target of genetic alteration in gastric carcinogenesis and suggests that overexpression of p73 might be triggered by physiological stresses accompanied with outgrowth of tumors, such as hypoxia or nutrient deprivation." @default.
- W2146038779 created "2016-06-24" @default.
- W2146038779 creator A5018017627 @default.
- W2146038779 creator A5029966999 @default.
- W2146038779 creator A5030626915 @default.
- W2146038779 creator A5040496951 @default.
- W2146038779 creator A5051679091 @default.
- W2146038779 creator A5069665291 @default.
- W2146038779 creator A5082396282 @default.
- W2146038779 date "2000-05-01" @default.
- W2146038779 modified "2023-09-29" @default.
- W2146038779 title "Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma." @default.
- W2146038779 cites W1528203329 @default.
- W2146038779 cites W1548270835 @default.
- W2146038779 cites W1577731619 @default.
- W2146038779 cites W1600735289 @default.
- W2146038779 cites W1675096266 @default.
- W2146038779 cites W1939117974 @default.
- W2146038779 cites W1943845680 @default.
- W2146038779 cites W1981548290 @default.
- W2146038779 cites W1985064409 @default.
- W2146038779 cites W2020408434 @default.
- W2146038779 cites W2075621444 @default.
- W2146038779 cites W2112410112 @default.
- W2146038779 cites W2118102989 @default.
- W2146038779 cites W2118815793 @default.
- W2146038779 cites W2126787895 @default.
- W2146038779 cites W2164712283 @default.
- W2146038779 cites W2274359797 @default.
- W2146038779 cites W2312368952 @default.
- W2146038779 cites W2333707271 @default.
- W2146038779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10815895" @default.
- W2146038779 hasPublicationYear "2000" @default.
- W2146038779 type Work @default.
- W2146038779 sameAs 2146038779 @default.
- W2146038779 citedByCount "30" @default.
- W2146038779 countsByYear W21460387792012 @default.
- W2146038779 countsByYear W21460387792013 @default.
- W2146038779 countsByYear W21460387792015 @default.
- W2146038779 countsByYear W21460387792016 @default.
- W2146038779 countsByYear W21460387792018 @default.
- W2146038779 crossrefType "journal-article" @default.
- W2146038779 hasAuthorship W2146038779A5018017627 @default.
- W2146038779 hasAuthorship W2146038779A5029966999 @default.
- W2146038779 hasAuthorship W2146038779A5030626915 @default.
- W2146038779 hasAuthorship W2146038779A5040496951 @default.
- W2146038779 hasAuthorship W2146038779A5051679091 @default.
- W2146038779 hasAuthorship W2146038779A5069665291 @default.
- W2146038779 hasAuthorship W2146038779A5082396282 @default.
- W2146038779 hasConcept C104317684 @default.
- W2146038779 hasConcept C127716648 @default.
- W2146038779 hasConcept C150194340 @default.
- W2146038779 hasConcept C153911025 @default.
- W2146038779 hasConcept C180754005 @default.
- W2146038779 hasConcept C190727270 @default.
- W2146038779 hasConcept C200544954 @default.
- W2146038779 hasConcept C201492766 @default.
- W2146038779 hasConcept C2778264664 @default.
- W2146038779 hasConcept C502942594 @default.
- W2146038779 hasConcept C54355233 @default.
- W2146038779 hasConcept C555283112 @default.
- W2146038779 hasConcept C86803240 @default.
- W2146038779 hasConceptScore W2146038779C104317684 @default.
- W2146038779 hasConceptScore W2146038779C127716648 @default.
- W2146038779 hasConceptScore W2146038779C150194340 @default.
- W2146038779 hasConceptScore W2146038779C153911025 @default.
- W2146038779 hasConceptScore W2146038779C180754005 @default.
- W2146038779 hasConceptScore W2146038779C190727270 @default.
- W2146038779 hasConceptScore W2146038779C200544954 @default.
- W2146038779 hasConceptScore W2146038779C201492766 @default.
- W2146038779 hasConceptScore W2146038779C2778264664 @default.
- W2146038779 hasConceptScore W2146038779C502942594 @default.
- W2146038779 hasConceptScore W2146038779C54355233 @default.
- W2146038779 hasConceptScore W2146038779C555283112 @default.
- W2146038779 hasConceptScore W2146038779C86803240 @default.
- W2146038779 hasIssue "5" @default.
- W2146038779 hasLocation W21460387791 @default.
- W2146038779 hasOpenAccess W2146038779 @default.
- W2146038779 hasPrimaryLocation W21460387791 @default.
- W2146038779 hasRelatedWork W1964985881 @default.
- W2146038779 hasRelatedWork W2038371691 @default.
- W2146038779 hasRelatedWork W2042634221 @default.
- W2146038779 hasRelatedWork W206323349 @default.
- W2146038779 hasRelatedWork W2104572303 @default.
- W2146038779 hasRelatedWork W2112930410 @default.
- W2146038779 hasRelatedWork W2126008912 @default.
- W2146038779 hasRelatedWork W2136396881 @default.
- W2146038779 hasRelatedWork W2146038779 @default.
- W2146038779 hasRelatedWork W2166717297 @default.
- W2146038779 hasVolume "6" @default.
- W2146038779 isParatext "false" @default.
- W2146038779 isRetracted "false" @default.
- W2146038779 magId "2146038779" @default.
- W2146038779 workType "article" @default.