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- W2146061473 abstract "THERE is a great need in the study of human inheritance for the discovery of additional hereditary characters of the sort exemplified by the A and B blood groups, the M and N agglutinogens, and taste deficiency to phenyl-thiourea. These as we may call them, owe their usefulness to several facts. In the first place, they may be ascertained with considerable ease and with a high degree of accuracy. Secondly, they appear to be little influenced by non-genetic factors. Further, the mode of inheritance of each is quite simple, involving in any case but a single pair or set of genes. And lastly, the frequency ratio of the different genes in a set is not too unequal in the population, which therefore contains a considerable proportion of each type of individual. Although such differences may be of no direct medical significance, at least three important genetical applications of such traits have already suggested themselves. Two of these applications, their use in medico-legal cases and in the diagnosis of types of twins, have already been extensively made. A third possible application lies in the prognosis of hereditary abnormalities with which we shall suppose they have been found to be closely linked. For the investigation of the mode of inheritance operating in any human trait, pedigree material may be collected in either one of two ways. The families may be collected wholly at random, that is, without regard to their composition, or they may be selected, only those families containing at least one affected member being included in the study. The latter method obviously suggests itself in the case of the numerous physical and physiological abnormalities, which are usually quite rare. The affected individuals come to the attention of the investigator through an inspection of schools, hospitals, and similar institutions. Special statistico-genetic methods are then required to eliminate from the test the various sources of bias introduced by the selective processes employed in gathering the families. In the case of the test factors, however, the individuals who belong to any gi-ven classification are not known until they are actually tested, and this, coupled with the fact that the different types are rather equally dis-" @default.
- W2146061473 created "2016-06-24" @default.
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- W2146061473 date "1939-09-01" @default.
- W2146061473 modified "2023-09-23" @default.
- W2146061473 title "Tests of Simple Mendelian Inheritance in Randomly Collected Data of One and Two Generations" @default.
- W2146061473 doi "https://doi.org/10.1080/01621459.1939.10503550" @default.
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