FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146068085> ?p ?o ?g. }

• W2146068085 endingPage "e313" @default.
• W2146068085 startingPage "e313" @default.
• W2146068085 abstract "Background Disruption of the intestinal homeostasis and tolerance towards the resident microbiota is a major mechanism involved in the development of inflammatory bowel disease. While some bacteria are inducers of disease, others, known as probiotics, are able to reduce inflammation. Because dendritic cells (DCs) play a central role in regulating immune responses and in inducing tolerance, we investigated their role in the anti-inflammatory potential of probiotic lactic acid bacteria. Methodology/Principal Findings Selected LAB strains, while efficiently taken up by DCs in vitro, induced a partial maturation of the cells. Transfer of probiotic-treated DCs conferred protection against 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. Protection was associated with a reduction of inflammatory scores and colonic expression of pro-inflammatory genes, while a high local expression of the immunoregulatory enzyme indolamine 2, 3 dioxgenase (IDO) was observed. The preventive effect of probiotic-pulsed DCs required not only MyD88-, TLR2- and NOD2-dependent signaling but also the induction of CD4+ CD25+ regulatory cells in an IL-10-independent pathway. Conclusions/Significance Altogether, these results suggest that selected probiotics can stimulate DC regulatory functions by targeting specific pattern-recognition receptors and pathways. The results not only emphasize the role of DCs in probiotic immune interactions, but indicate a possible role in immune-intervention therapy for IBD." @default.
• W2146068085 created "2016-06-24" @default.
• W2146068085 creator A5011379140 @default.
• W2146068085 creator A5028863392 @default.
• W2146068085 creator A5031318519 @default.
• W2146068085 creator A5058433885 @default.
• W2146068085 creator A5061011015 @default.
• W2146068085 creator A5067306025 @default.
• W2146068085 creator A5086665853 @default.
• W2146068085 creator A5087285781 @default.
• W2146068085 date "2007-03-21" @default.
• W2146068085 modified "2023-10-16" @default.
• W2146068085 title "A Key Role of Dendritic Cells in Probiotic Functionality" @default.
• W2146068085 cites W1491553594 @default.
• W2146068085 cites W1511823445 @default.
• W2146068085 cites W1533682423 @default.
• W2146068085 cites W1542250239 @default.
• W2146068085 cites W1545517148 @default.
• W2146068085 cites W1584352387 @default.
• W2146068085 cites W1601070312 @default.
• W2146068085 cites W1606071414 @default.
• W2146068085 cites W1642457845 @default.
• W2146068085 cites W1648036481 @default.
• W2146068085 cites W1700278844 @default.
• W2146068085 cites W1922734004 @default.
• W2146068085 cites W1952598732 @default.
• W2146068085 cites W1965830486 @default.
• W2146068085 cites W1967960292 @default.
• W2146068085 cites W1968082302 @default.
• W2146068085 cites W1975929837 @default.
• W2146068085 cites W1990698093 @default.
• W2146068085 cites W2009938323 @default.
• W2146068085 cites W2013206104 @default.
• W2146068085 cites W2018542503 @default.
• W2146068085 cites W2020358486 @default.
• W2146068085 cites W2040821545 @default.
• W2146068085 cites W2051591207 @default.
• W2146068085 cites W2057809738 @default.
• W2146068085 cites W2062512887 @default.
• W2146068085 cites W2069968649 @default.
• W2146068085 cites W2073144071 @default.
• W2146068085 cites W2077511764 @default.
• W2146068085 cites W2083089709 @default.
• W2146068085 cites W2092235636 @default.
• W2146068085 cites W2105270270 @default.
• W2146068085 cites W2111633730 @default.
• W2146068085 cites W2114424280 @default.
• W2146068085 cites W2114435349 @default.
• W2146068085 cites W2116185627 @default.
• W2146068085 cites W2117616114 @default.
• W2146068085 cites W2130946949 @default.
• W2146068085 cites W2132644314 @default.
• W2146068085 cites W2132731835 @default.
• W2146068085 cites W2138291177 @default.
• W2146068085 cites W2139563813 @default.
• W2146068085 cites W2146317790 @default.
• W2146068085 cites W2152398830 @default.
• W2146068085 cites W2157886452 @default.
• W2146068085 cites W2159549010 @default.
• W2146068085 cites W2161354474 @default.
• W2146068085 cites W2165823752 @default.
• W2146068085 cites W2170631284 @default.
• W2146068085 cites W2335128141 @default.
• W2146068085 cites W2465619737 @default.
• W2146068085 cites W2564152524 @default.
• W2146068085 cites W4247694430 @default.
• W2146068085 doi "https://doi.org/10.1371/journal.pone.0000313" @default.
• W2146068085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1819555" @default.
• W2146068085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17375199" @default.
• W2146068085 hasPublicationYear "2007" @default.
• W2146068085 type Work @default.
• W2146068085 sameAs 2146068085 @default.
• W2146068085 citedByCount "249" @default.
• W2146068085 countsByYear W21460680852012 @default.
• W2146068085 countsByYear W21460680852013 @default.
• W2146068085 countsByYear W21460680852014 @default.
• W2146068085 countsByYear W21460680852015 @default.
• W2146068085 countsByYear W21460680852016 @default.
• W2146068085 countsByYear W21460680852017 @default.
• W2146068085 countsByYear W21460680852018 @default.
• W2146068085 countsByYear W21460680852019 @default.
• W2146068085 countsByYear W21460680852020 @default.
• W2146068085 countsByYear W21460680852021 @default.
• W2146068085 countsByYear W21460680852022 @default.
• W2146068085 countsByYear W21460680852023 @default.
• W2146068085 crossrefType "journal-article" @default.
• W2146068085 hasAuthorship W2146068085A5011379140 @default.
• W2146068085 hasAuthorship W2146068085A5028863392 @default.
• W2146068085 hasAuthorship W2146068085A5031318519 @default.
• W2146068085 hasAuthorship W2146068085A5058433885 @default.
• W2146068085 hasAuthorship W2146068085A5061011015 @default.
• W2146068085 hasAuthorship W2146068085A5067306025 @default.
• W2146068085 hasAuthorship W2146068085A5086665853 @default.
• W2146068085 hasAuthorship W2146068085A5087285781 @default.
• W2146068085 hasBestOaLocation W21460680851 @default.
• W2146068085 hasConcept C111289621 @default.
• W2146068085 hasConcept C136449434 @default.
• W2146068085 hasConcept C142724271 @default.

• next