FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146069439> ?p ?o ?g. }

• W2146069439 endingPage "149" @default.
• W2146069439 startingPage "135" @default.
• W2146069439 abstract "Release of surfactant from pulmonary type II epithelial cells was stimulated by the β-adrenergic agonist terbutaline and the diterpene forskolin. Cytosolic cyclic adenosine monophosphate (cAMP) concentrations increased significantly following exposure to terbutaline or forskolin and reached maximal levels within 5 min after treatment, Terbutaline and forskolin had a synergistic effect on cytosolic cAMP levels when added simultaneously. cAMP-dependent protein kinase activity was identified in cytosolic preparations of type II pneumocytes by phosphorylation of the peptide substrate Kemptide (Leu-Arg-Arg-Ala-Ser-Leu-Gly) and binding of 3H-cAMP to the regulatory components of cAMP-dependent protein kinase. Type I and type II regulatory subunits of the cAMP-dependent kinase were present in approximately equal concentrations in type II cell cytosol. Activation ratio of cAMP-dependent protein kinase in cultured type II cells increased significantly in the presence of terbutaline, forskolin, or terbutaline plus forskolin. Activation ratios increased from 0.45 ± 0.03 for control cells to 0.96 ± 0.06 for cells exposed to ter-butaline (10 μM) plus forskolin (5 μM) for 20 min. Release of3H-phosphatidylcholine was also stimulated by terbutaline and forskolin. Effects of terbutaline and forskolin on surfactant release were approximately additive. Our results demonstrated increased cytosolic cAMP levels, increased cAMP-dependent protein kinase activation ratios, and subsequent augmented surfactant release from isolated type II pneumocytes in response to terbutaline and forskolin. These data support a role for activation of cAMP-dependent protein kinase as a mediator of surfactant release and document the utility of forskolin for study of cAMP-mediated effects in isolated type II cells." @default.
• W2146069439 created "2016-06-24" @default.
• W2146069439 creator A5000580319 @default.
• W2146069439 creator A5001813162 @default.
• W2146069439 creator A5028477677 @default.
• W2146069439 creator A5088303892 @default.
• W2146069439 creator A5090285910 @default.
• W2146069439 date "1985-01-01" @default.
• W2146069439 modified "2023-09-27" @default.
• W2146069439 title "Activation of cAMP Dependent Protein Kinase during Surfactant Release from Type II Pneumocytes" @default.
• W2146069439 cites W1483985690 @default.
• W2146069439 cites W1518913349 @default.
• W2146069439 cites W1530944849 @default.
• W2146069439 cites W1549058817 @default.
• W2146069439 cites W1570227839 @default.
• W2146069439 cites W1576014737 @default.
• W2146069439 cites W1775749144 @default.
• W2146069439 cites W1840067061 @default.
• W2146069439 cites W1970299531 @default.
• W2146069439 cites W1982690338 @default.
• W2146069439 cites W1983157906 @default.
• W2146069439 cites W1985558625 @default.
• W2146069439 cites W2012407792 @default.
• W2146069439 cites W2023833056 @default.
• W2146069439 cites W2024296404 @default.
• W2146069439 cites W2025646177 @default.
• W2146069439 cites W2026992786 @default.
• W2146069439 cites W2028758117 @default.
• W2146069439 cites W2032547040 @default.
• W2146069439 cites W2037612886 @default.
• W2146069439 cites W2053823563 @default.
• W2146069439 cites W2055857435 @default.
• W2146069439 cites W2061816841 @default.
• W2146069439 cites W2063423031 @default.
• W2146069439 cites W2072556168 @default.
• W2146069439 cites W2089012764 @default.
• W2146069439 cites W2114094740 @default.
• W2146069439 cites W2129882506 @default.
• W2146069439 cites W2168526937 @default.
• W2146069439 cites W2301599923 @default.
• W2146069439 cites W4296759590 @default.
• W2146069439 doi "https://doi.org/10.3109/01902148509061533" @default.
• W2146069439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2998742" @default.
• W2146069439 hasPublicationYear "1985" @default.
• W2146069439 type Work @default.
• W2146069439 sameAs 2146069439 @default.
• W2146069439 citedByCount "42" @default.
• W2146069439 countsByYear W21460694392013 @default.
• W2146069439 countsByYear W21460694392015 @default.
• W2146069439 countsByYear W21460694392017 @default.
• W2146069439 crossrefType "journal-article" @default.
• W2146069439 hasAuthorship W2146069439A5000580319 @default.
• W2146069439 hasAuthorship W2146069439A5001813162 @default.
• W2146069439 hasAuthorship W2146069439A5028477677 @default.
• W2146069439 hasAuthorship W2146069439A5088303892 @default.
• W2146069439 hasAuthorship W2146069439A5090285910 @default.
• W2146069439 hasConcept C126322002 @default.
• W2146069439 hasConcept C134018914 @default.
• W2146069439 hasConcept C181199279 @default.
• W2146069439 hasConcept C184235292 @default.
• W2146069439 hasConcept C185592680 @default.
• W2146069439 hasConcept C24998067 @default.
• W2146069439 hasConcept C2776042228 @default.
• W2146069439 hasConcept C2776090920 @default.
• W2146069439 hasConcept C2779033064 @default.
• W2146069439 hasConcept C2779276759 @default.
• W2146069439 hasConcept C2780252434 @default.
• W2146069439 hasConcept C55493867 @default.
• W2146069439 hasConcept C71924100 @default.
• W2146069439 hasConcept C86803240 @default.
• W2146069439 hasConcept C97029542 @default.
• W2146069439 hasConcept C98539663 @default.
• W2146069439 hasConceptScore W2146069439C126322002 @default.
• W2146069439 hasConceptScore W2146069439C134018914 @default.
• W2146069439 hasConceptScore W2146069439C181199279 @default.
• W2146069439 hasConceptScore W2146069439C184235292 @default.
• W2146069439 hasConceptScore W2146069439C185592680 @default.
• W2146069439 hasConceptScore W2146069439C24998067 @default.
• W2146069439 hasConceptScore W2146069439C2776042228 @default.
• W2146069439 hasConceptScore W2146069439C2776090920 @default.
• W2146069439 hasConceptScore W2146069439C2779033064 @default.
• W2146069439 hasConceptScore W2146069439C2779276759 @default.
• W2146069439 hasConceptScore W2146069439C2780252434 @default.
• W2146069439 hasConceptScore W2146069439C55493867 @default.
• W2146069439 hasConceptScore W2146069439C71924100 @default.
• W2146069439 hasConceptScore W2146069439C86803240 @default.
• W2146069439 hasConceptScore W2146069439C97029542 @default.
• W2146069439 hasConceptScore W2146069439C98539663 @default.
• W2146069439 hasIssue "1-2" @default.
• W2146069439 hasLocation W21460694391 @default.
• W2146069439 hasLocation W21460694392 @default.
• W2146069439 hasOpenAccess W2146069439 @default.
• W2146069439 hasPrimaryLocation W21460694391 @default.
• W2146069439 hasRelatedWork W1974268105 @default.
• W2146069439 hasRelatedWork W1975696001 @default.
• W2146069439 hasRelatedWork W2008261372 @default.
• W2146069439 hasRelatedWork W2048823012 @default.
• W2146069439 hasRelatedWork W2053936620 @default.

• next