Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146100186> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2146100186 endingPage "75" @default.
- W2146100186 startingPage "1169" @default.
- W2146100186 abstract "Standard or investigative immunosuppressive therapies for cutaneous chronic graft-versus-host disease (GVHD) may prove not only ineffective but also cause serious adverse effects. Repeated exposure of the skin to ultraviolet radiation in the wavelength range 340-400 nm (so-called ultraviolet A1) was recently reported to have a strong local (intracutaneous) immunomodulatory activity. This study was undertaken to evaluate efficacy and safety of this phototherapy.Nine patients with cutaneous (4 lichenoid and 5 sclerodermoid) GVHD and mild or no other organ involvement were enrolled. All patients had developed serious drug toxicity and/or opportunistic infections. Phototherapy was administered three times a week.Complete remission was seen in 5 (2 lichenoid and 3 sclerodermoid) cases and a partial improvement in 4 (2 lichenoid and 2 sclerodermoid) after having received 15.8+/-3.8 (lichenoid GVHD) or 21.6+/-8.0 (sclerodermoid GVHD) sessions of phototherapy. Adverse effects were not registered. At follow-up (range: 6-25 months), two patients with sclerodermoid lesions relapsed after 5 months but responded to another treatment cycle. Patients with lichenoid GVHD showed relapses within one month and prolonged maintenance phototherapy was needed. Problems of drug toxicity and opportunistic infections improved as phototherapy allowed the reduction or interruption of systemic drug therapies.Ultraviolet A1 phototherapy may be considered as an appropriate therapeutic approach for sclerodermoid GVHD with no or mild involvement of internal organs. Patients with lichenoid GVHD should be treated only if they develop serious adverse effects to immunosuppressive therapies and opportunistic infections because of the carcinogenic hazard of high cumulative doses of ultraviolet A1 radiation." @default.
- W2146100186 created "2016-06-24" @default.
- W2146100186 creator A5020210038 @default.
- W2146100186 creator A5029163913 @default.
- W2146100186 creator A5040570721 @default.
- W2146100186 creator A5047500191 @default.
- W2146100186 creator A5076168488 @default.
- W2146100186 creator A5078025781 @default.
- W2146100186 creator A5090000319 @default.
- W2146100186 date "2003-10-01" @default.
- W2146100186 modified "2023-09-23" @default.
- W2146100186 title "Prospects for ultraviolet A1 phototherapy as a treatment for chronic cutaneous graft-versus-host disease." @default.
- W2146100186 cites W132506274 @default.
- W2146100186 cites W1597544321 @default.
- W2146100186 cites W1968971111 @default.
- W2146100186 cites W1999975581 @default.
- W2146100186 cites W2003856344 @default.
- W2146100186 cites W2008201186 @default.
- W2146100186 cites W2018052299 @default.
- W2146100186 cites W2025025945 @default.
- W2146100186 cites W2054955905 @default.
- W2146100186 cites W2067480394 @default.
- W2146100186 cites W2068682286 @default.
- W2146100186 cites W2081957391 @default.
- W2146100186 cites W2087111212 @default.
- W2146100186 cites W2136669587 @default.
- W2146100186 cites W2316826709 @default.
- W2146100186 cites W2331991023 @default.
- W2146100186 cites W2339981418 @default.
- W2146100186 cites W2416853657 @default.
- W2146100186 cites W2491862924 @default.
- W2146100186 cites W86597909 @default.
- W2146100186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14555314" @default.
- W2146100186 hasPublicationYear "2003" @default.
- W2146100186 type Work @default.
- W2146100186 sameAs 2146100186 @default.
- W2146100186 citedByCount "13" @default.
- W2146100186 countsByYear W21461001862012 @default.
- W2146100186 countsByYear W21461001862015 @default.
- W2146100186 countsByYear W21461001862017 @default.
- W2146100186 countsByYear W21461001862018 @default.
- W2146100186 countsByYear W21461001862019 @default.
- W2146100186 countsByYear W21461001862020 @default.
- W2146100186 countsByYear W21461001862022 @default.
- W2146100186 crossrefType "journal-article" @default.
- W2146100186 hasAuthorship W2146100186A5020210038 @default.
- W2146100186 hasAuthorship W2146100186A5029163913 @default.
- W2146100186 hasAuthorship W2146100186A5040570721 @default.
- W2146100186 hasAuthorship W2146100186A5047500191 @default.
- W2146100186 hasAuthorship W2146100186A5076168488 @default.
- W2146100186 hasAuthorship W2146100186A5078025781 @default.
- W2146100186 hasAuthorship W2146100186A5090000319 @default.
- W2146100186 hasConcept C126322002 @default.
- W2146100186 hasConcept C16005928 @default.
- W2146100186 hasConcept C197934379 @default.
- W2146100186 hasConcept C2779134260 @default.
- W2146100186 hasConcept C2779972918 @default.
- W2146100186 hasConcept C2780035454 @default.
- W2146100186 hasConcept C29730261 @default.
- W2146100186 hasConcept C71924100 @default.
- W2146100186 hasConcept C98274493 @default.
- W2146100186 hasConceptScore W2146100186C126322002 @default.
- W2146100186 hasConceptScore W2146100186C16005928 @default.
- W2146100186 hasConceptScore W2146100186C197934379 @default.
- W2146100186 hasConceptScore W2146100186C2779134260 @default.
- W2146100186 hasConceptScore W2146100186C2779972918 @default.
- W2146100186 hasConceptScore W2146100186C2780035454 @default.
- W2146100186 hasConceptScore W2146100186C29730261 @default.
- W2146100186 hasConceptScore W2146100186C71924100 @default.
- W2146100186 hasConceptScore W2146100186C98274493 @default.
- W2146100186 hasIssue "10" @default.
- W2146100186 hasLocation W21461001861 @default.
- W2146100186 hasOpenAccess W2146100186 @default.
- W2146100186 hasPrimaryLocation W21461001861 @default.
- W2146100186 hasRelatedWork W1969676110 @default.
- W2146100186 hasRelatedWork W2002120878 @default.
- W2146100186 hasRelatedWork W2019517015 @default.
- W2146100186 hasRelatedWork W2047967234 @default.
- W2146100186 hasRelatedWork W2118496982 @default.
- W2146100186 hasRelatedWork W2165917467 @default.
- W2146100186 hasRelatedWork W2338987740 @default.
- W2146100186 hasRelatedWork W2439875401 @default.
- W2146100186 hasRelatedWork W3011676578 @default.
- W2146100186 hasRelatedWork W2525756941 @default.
- W2146100186 hasVolume "88" @default.
- W2146100186 isParatext "false" @default.
- W2146100186 isRetracted "false" @default.
- W2146100186 magId "2146100186" @default.
- W2146100186 workType "article" @default.