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- W2146102816 abstract "The identification of tumor-specific antigens in the last few years provides the basis for novel, specific immunotherapeutic strategies, since these antigens are potential targets for MHC-I-restricted CD 8+ cytotoxic lymphocytes which mediate tumor rejection in animal models (Boon et al. 1994; Greenberg 1991). Antigens so far defined as being truly tumor-specific can be divided into different categories: mutated proteins such as k-ras, p53, or erb-b 2, fusion proteins, which are gene products of chromosomal translocations, e.g., bcr/abl (p 210) in chronic myeloid leukemia, idiotypic determinants of immunoglobulins, or T-cell receptors in lymphoid malignancies. Furthermore, shared antigens such as MAGE, which are expressed by melanoma and several other tumors but not in normal tissues (except testis), and differentiation antigens such as MelanA/Mart 1 and tyrosine in melanoma, can serve as targets for immunotherapy." @default.
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- W2146102816 date "1998-01-01" @default.
- W2146102816 modified "2023-09-25" @default.
- W2146102816 title "Dendritic Cells for Somatic Gene Therapy" @default.
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- W2146102816 doi "https://doi.org/10.1007/978-3-642-46836-0_9" @default.
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