Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146106809> ?p ?o ?g. }
- W2146106809 endingPage "2121" @default.
- W2146106809 startingPage "2116" @default.
- W2146106809 abstract "ABSTRACT A reservoir of pseudogene alleles encoding the primary adhesin VlhA occurs in the avian pathogen Mycoplasma synoviae . Recombination between this reservoir and its single expression site was predicted to result in lineages of M. synoviae that each express a different vlhA allele as a consequence of host immune responses to those antigens. Such interstrain diversity at the vlhA expression site, including major differences in the predicted secondary structures of their expressed adhesins, was confirmed in 14 specimens of M. synoviae . Corresponding functional differences in the extent to which they agglutinated erythrocytes, a quantitative proxy for VlhA-mediated cytadherence, were also evident. There was a >20-fold difference between the highest- and lowest-agglutinating strains and a rheostatic distribution of intermediate phenotypes among the others (Tukey-Kramer honestly significant difference [HSD], P < 0.001). Coincubation with the sialic acid analog 2-deoxy-2,3-didehydro- N -acetylneuraminate inhibited hemagglutination in a pattern correlated with endogenous sialidase activity ( r = 0.91, P < 0.001), although not consistently to the same extent that erythrocyte pretreatment with sialidase purified from Clostridium perfringens did ( P < 0.05). The striking correlation between the ranked hemagglutination and endogenous sialidase activities of these strains (Spearman's r = 0.874, P < 0.001) is evidence that host-induced vlhA allele switching indirectly drives sequence diversity in the passenger sialidase gene of M. synoviae ." @default.
- W2146106809 created "2016-06-24" @default.
- W2146106809 creator A5007460736 @default.
- W2146106809 creator A5041697462 @default.
- W2146106809 date "2011-05-01" @default.
- W2146106809 modified "2023-09-27" @default.
- W2146106809 title "Diversity of Expressed <i>vlhA</i> Adhesin Sequences and Intermediate Hemagglutination Phenotypes in Mycoplasma synoviae" @default.
- W2146106809 cites W1491040459 @default.
- W2146106809 cites W150792625 @default.
- W2146106809 cites W1526989036 @default.
- W2146106809 cites W1537641994 @default.
- W2146106809 cites W1989639957 @default.
- W2146106809 cites W1993054962 @default.
- W2146106809 cites W1993472930 @default.
- W2146106809 cites W2001314854 @default.
- W2146106809 cites W2016314181 @default.
- W2146106809 cites W2016968449 @default.
- W2146106809 cites W2019545199 @default.
- W2146106809 cites W2019594697 @default.
- W2146106809 cites W2029967157 @default.
- W2146106809 cites W2038009272 @default.
- W2146106809 cites W2039181792 @default.
- W2146106809 cites W2053098217 @default.
- W2146106809 cites W2053157330 @default.
- W2146106809 cites W2062868513 @default.
- W2146106809 cites W2070319351 @default.
- W2146106809 cites W2079338761 @default.
- W2146106809 cites W2081703048 @default.
- W2146106809 cites W2087465598 @default.
- W2146106809 cites W2092681433 @default.
- W2146106809 cites W2094744817 @default.
- W2146106809 cites W2096825780 @default.
- W2146106809 cites W2106882534 @default.
- W2146106809 cites W2107651145 @default.
- W2146106809 cites W2107836487 @default.
- W2146106809 cites W2110998010 @default.
- W2146106809 cites W2117587459 @default.
- W2146106809 cites W2122437468 @default.
- W2146106809 cites W2133917457 @default.
- W2146106809 cites W2143249308 @default.
- W2146106809 cites W2147783541 @default.
- W2146106809 cites W2147865566 @default.
- W2146106809 cites W2150522426 @default.
- W2146106809 cites W2158616404 @default.
- W2146106809 cites W2166037975 @default.
- W2146106809 cites W2167481219 @default.
- W2146106809 cites W2170565120 @default.
- W2146106809 cites W2176555410 @default.
- W2146106809 cites W2313113929 @default.
- W2146106809 cites W2316725329 @default.
- W2146106809 cites W2326767409 @default.
- W2146106809 cites W2329756095 @default.
- W2146106809 doi "https://doi.org/10.1128/jb.00022-11" @default.
- W2146106809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3133063" @default.
- W2146106809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21378196" @default.
- W2146106809 hasPublicationYear "2011" @default.
- W2146106809 type Work @default.
- W2146106809 sameAs 2146106809 @default.
- W2146106809 citedByCount "15" @default.
- W2146106809 countsByYear W21461068092012 @default.
- W2146106809 countsByYear W21461068092014 @default.
- W2146106809 countsByYear W21461068092015 @default.
- W2146106809 countsByYear W21461068092016 @default.
- W2146106809 countsByYear W21461068092018 @default.
- W2146106809 countsByYear W21461068092022 @default.
- W2146106809 crossrefType "journal-article" @default.
- W2146106809 hasAuthorship W2146106809A5007460736 @default.
- W2146106809 hasAuthorship W2146106809A5041697462 @default.
- W2146106809 hasBestOaLocation W21461068092 @default.
- W2146106809 hasConcept C104317684 @default.
- W2146106809 hasConcept C127716648 @default.
- W2146106809 hasConcept C134164806 @default.
- W2146106809 hasConcept C159654299 @default.
- W2146106809 hasConcept C179470777 @default.
- W2146106809 hasConcept C180754005 @default.
- W2146106809 hasConcept C2522874641 @default.
- W2146106809 hasConcept C2778838687 @default.
- W2146106809 hasConcept C2780115458 @default.
- W2146106809 hasConcept C2781151156 @default.
- W2146106809 hasConcept C2910317154 @default.
- W2146106809 hasConcept C34343649 @default.
- W2146106809 hasConcept C54355233 @default.
- W2146106809 hasConcept C60987743 @default.
- W2146106809 hasConcept C73695083 @default.
- W2146106809 hasConcept C86803240 @default.
- W2146106809 hasConcept C89423630 @default.
- W2146106809 hasConceptScore W2146106809C104317684 @default.
- W2146106809 hasConceptScore W2146106809C127716648 @default.
- W2146106809 hasConceptScore W2146106809C134164806 @default.
- W2146106809 hasConceptScore W2146106809C159654299 @default.
- W2146106809 hasConceptScore W2146106809C179470777 @default.
- W2146106809 hasConceptScore W2146106809C180754005 @default.
- W2146106809 hasConceptScore W2146106809C2522874641 @default.
- W2146106809 hasConceptScore W2146106809C2778838687 @default.
- W2146106809 hasConceptScore W2146106809C2780115458 @default.
- W2146106809 hasConceptScore W2146106809C2781151156 @default.
- W2146106809 hasConceptScore W2146106809C2910317154 @default.
- W2146106809 hasConceptScore W2146106809C34343649 @default.