Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146122910> ?p ?o ?g. }
- W2146122910 endingPage "5115" @default.
- W2146122910 startingPage "5104" @default.
- W2146122910 abstract "Nuclear pore complexes (NPCs) span the nuclear envelope and mediate communication between the nucleus and the cytoplasm. To obtain insight into the structure and function of NPCs of multicellular organisms, we have initiated an extensive analysis of Caenorhabditis elegans nucleoporins. Of 20 assigned C. elegans nucleoporin genes, 17 were found to be essential for embryonic development either alone or in combination. In several cases, depletion of nucleoporins by RNAi caused severe defects in nuclear appearance. More specifically, the C. elegans homologs of vertebrate Nup93 and Nup205 were each found to be required for normal NPC distribution in the nuclear envelope in vivo. Depletion of Nup93 or Nup205 caused a failure in nuclear exclusion of nonnuclear macromolecules of approximately 70 kDa without preventing active nuclear protein import or the assembly of the nuclear envelope. The defects in NPC exclusion were accompanied by abnormal chromatin condensation and early embryonic arrest. Thus, the contribution to NPC structure of Nup93 and Nup205 is essential for establishment of normal NPC function and for cell viability." @default.
- W2146122910 created "2016-06-24" @default.
- W2146122910 creator A5021703991 @default.
- W2146122910 creator A5050431526 @default.
- W2146122910 creator A5080948421 @default.
- W2146122910 date "2003-12-01" @default.
- W2146122910 modified "2023-09-27" @default.
- W2146122910 title "<i>Caenorhabditis elegans</i>Nucleoporins Nup93 and Nup205 Determine the Limit of Nuclear Pore Complex Size Exclusion In Vivo" @default.
- W2146122910 cites W1486450190 @default.
- W2146122910 cites W1560703397 @default.
- W2146122910 cites W1898015186 @default.
- W2146122910 cites W1911220294 @default.
- W2146122910 cites W1932856142 @default.
- W2146122910 cites W1971531897 @default.
- W2146122910 cites W1978450158 @default.
- W2146122910 cites W1985732160 @default.
- W2146122910 cites W1986089358 @default.
- W2146122910 cites W2011052397 @default.
- W2146122910 cites W2015646338 @default.
- W2146122910 cites W2030052455 @default.
- W2146122910 cites W2030299285 @default.
- W2146122910 cites W2038486012 @default.
- W2146122910 cites W2038492783 @default.
- W2146122910 cites W2041696216 @default.
- W2146122910 cites W2044989903 @default.
- W2146122910 cites W2050908337 @default.
- W2146122910 cites W2065719801 @default.
- W2146122910 cites W2076213038 @default.
- W2146122910 cites W2077896867 @default.
- W2146122910 cites W2085304899 @default.
- W2146122910 cites W2090385798 @default.
- W2146122910 cites W2095744767 @default.
- W2146122910 cites W2096810446 @default.
- W2146122910 cites W2097627269 @default.
- W2146122910 cites W2098145494 @default.
- W2146122910 cites W2107210402 @default.
- W2146122910 cites W2112510720 @default.
- W2146122910 cites W2118270653 @default.
- W2146122910 cites W2121877938 @default.
- W2146122910 cites W2128491398 @default.
- W2146122910 cites W2133201628 @default.
- W2146122910 cites W2133695223 @default.
- W2146122910 cites W2134263455 @default.
- W2146122910 cites W2134425963 @default.
- W2146122910 cites W2135241130 @default.
- W2146122910 cites W2136931082 @default.
- W2146122910 cites W2139317494 @default.
- W2146122910 cites W2140235777 @default.
- W2146122910 cites W2145893833 @default.
- W2146122910 cites W2146666887 @default.
- W2146122910 cites W2150687522 @default.
- W2146122910 cites W2151298994 @default.
- W2146122910 cites W2157289517 @default.
- W2146122910 cites W2159577341 @default.
- W2146122910 cites W2161335608 @default.
- W2146122910 cites W2165306451 @default.
- W2146122910 cites W2172088410 @default.
- W2146122910 cites W2214759326 @default.
- W2146122910 cites W246252021 @default.
- W2146122910 doi "https://doi.org/10.1091/mbc.e03-04-0237" @default.
- W2146122910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/284812" @default.
- W2146122910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12937276" @default.
- W2146122910 hasPublicationYear "2003" @default.
- W2146122910 type Work @default.
- W2146122910 sameAs 2146122910 @default.
- W2146122910 citedByCount "168" @default.
- W2146122910 countsByYear W21461229102012 @default.
- W2146122910 countsByYear W21461229102013 @default.
- W2146122910 countsByYear W21461229102014 @default.
- W2146122910 countsByYear W21461229102015 @default.
- W2146122910 countsByYear W21461229102016 @default.
- W2146122910 countsByYear W21461229102017 @default.
- W2146122910 countsByYear W21461229102018 @default.
- W2146122910 countsByYear W21461229102019 @default.
- W2146122910 countsByYear W21461229102020 @default.
- W2146122910 countsByYear W21461229102021 @default.
- W2146122910 countsByYear W21461229102022 @default.
- W2146122910 countsByYear W21461229102023 @default.
- W2146122910 crossrefType "journal-article" @default.
- W2146122910 hasAuthorship W2146122910A5021703991 @default.
- W2146122910 hasAuthorship W2146122910A5050431526 @default.
- W2146122910 hasAuthorship W2146122910A5080948421 @default.
- W2146122910 hasBestOaLocation W21461229104 @default.
- W2146122910 hasConcept C104317684 @default.
- W2146122910 hasConcept C126725582 @default.
- W2146122910 hasConcept C166703698 @default.
- W2146122910 hasConcept C190062978 @default.
- W2146122910 hasConcept C2778944004 @default.
- W2146122910 hasConcept C2780114586 @default.
- W2146122910 hasConcept C28859421 @default.
- W2146122910 hasConcept C29512474 @default.
- W2146122910 hasConcept C54355233 @default.
- W2146122910 hasConcept C59157529 @default.
- W2146122910 hasConcept C65871279 @default.
- W2146122910 hasConcept C67705224 @default.
- W2146122910 hasConcept C68556195 @default.
- W2146122910 hasConcept C83640560 @default.
- W2146122910 hasConcept C86339819 @default.