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• W2146146316 endingPage "2598" @default.
• W2146146316 startingPage "2588" @default.
• W2146146316 abstract "Abstract The transcription factor CCAAT/enhancer binding protein β (C/EBPβ) is involved in cellular responses to oncogenic and physiologic Ras signals. C/EBPβ is required for premature senescence of primary mouse fibroblasts induced by expression of H-RasV12, demonstrating its role in oncogene-induced senescence. Here, we have investigated the mechanisms by which Ras inhibits proliferation of normal cells but transforms immortalized cells. We show that oncogenic Ras down-regulates C/EBPβ expression in NIH 3T3 cells, which are immortalized by a deletion of the CDKN2A locus and, therefore, lack the p16Ink4a and p19Arf tumor suppressors. RasV12-induced silencing of C/EBPβ occurred at the mRNA level and involved both the Raf–mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase–ERK and phosphatidylinositol 3-kinase signaling pathways. Oncogenic Ras decreased C/EBPβ expression in Ink4a/Arf−/− mouse embryo fibroblasts (MEF) but increased C/EBPβ levels in wild-type MEFs. C/EBPβ down-regulation in NIH 3T3 cells was reversed by expression of p19Arf, but not of p53 or p16Ink4a, highlighting a critical role for p19Arf in sustaining C/EBPβ levels. Ectopic expression of p34 C/EBPβ (LAP) inhibited RasV12-mediated transformation of NIH 3T3 cells, suppressed their tumorigenicity in nude mice, and reactivated expression of the proapoptotic Fas receptor, which is also down-regulated by Ras. Our findings indicate that Cebpb gene silencing eliminates a growth inhibitory transcription factor that would otherwise restrain oncogenesis. We propose that C/EBPβ is part of a p53-independent, p19Arf-mediated network that enforces Ras-induced cell cycle arrest and tumor suppression in primary fibroblasts. [Cancer Res 2009;69(6):2588–98]" @default.
• W2146146316 created "2016-06-24" @default.
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• W2146146316 date "2009-03-15" @default.
• W2146146316 modified "2023-10-17" @default.
• W2146146316 title "RasV12-Mediated Down-regulation of CCAAT/Enhancer Binding Protein β in Immortalized Fibroblasts Requires Loss of p19Arf and Facilitates Bypass of Oncogene-Induced Senescence" @default.
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• W2146146316 doi "https://doi.org/10.1158/0008-5472.can-08-2312" @default.
• W2146146316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2693277" @default.
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