FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146147975> ?p ?o ?g. }

• W2146147975 endingPage "1636" @default.
• W2146147975 startingPage "1626" @default.
• W2146147975 abstract "It has been proposed that abnormal myo-inositol metabolism may be a factor in the development of diabetic complications. Studies with animal models of diabetes and cultured cells have suggested that hyperglycemia by an unknown mechanism may alter myo-inositol metabolism and content. Recently, we have shown that L-fucose, a 6-deoxy sugar whose content has been reported to be increased in diabetes, is a potent inhibitor of myo-inositol transport. To examine the effect of L-fucose on myo-inositol metabolism, neuroblastoma cells were cultured in medium supplemented with L-fucose. L-Fucose is a competitive inhibitor of Na(+)-dependent, high-affinity myo-inositol transport. The Ki for inhibition of myo-inositol transport by L-fucose is about 3 mM. L-Fucose is taken up and accumulates in neuroblastoma cells. The uptake of L-fucose is inhibited by Na+ depletion, D-glucose, glucose analogues, phloridzin, and cytochalasin B. In contrast, neither myo-inositol nor L-glucose inhibits L-fucose uptake. Chronic exposure of neuroblastoma cells to 1-30 mM L-fucose causes a decrease in myo-inositol accumulation and incorporation into inositol phospholipids, intracellular free myo-inositol content, and phosphatidylinositol levels. Na+,K(+)-ATPase transport activity is decreased by about 15% by acute or chronic exposure of neuroblastoma cells to L-fucose. Similar defects occur when neuroblastoma cells are exposed chronically to 30 mM glucose. Cell myo-inositol metabolism and Na+/K(+)-pump activity are maintained when 250 microM myo-inositol is added to the L-fucose-supplemented medium. Unlike the effect of chronic exposure of neuroblastoma cells to medium containing 30 mM glucose, the resting membrane potential of neuroblastoma cells is not altered by chronic exposure of the cells to 30 mM L-fucose. The effect of L-fucose on cultured neuroblastoma cell properties occurs at concentrations of L-fucose which may exist in the diabetic milieu. These data suggest that increased concentrations of L-fucose may have a role in myo-inositol-related defects in mammalian cells." @default.
• W2146147975 created "2016-06-24" @default.
• W2146147975 creator A5034151735 @default.
• W2146147975 creator A5047389602 @default.
• W2146147975 creator A5052263203 @default.
• W2146147975 creator A5082694775 @default.
• W2146147975 date "1992-05-01" @default.
• W2146147975 modified "2023-10-16" @default.
• W2146147975 title "L-Fucose Is a Potent Inhibitor of myo-Inositol Transport and Metabolism in Cultured Neuroblastoma Cells" @default.
• W2146147975 cites W1504768758 @default.
• W2146147975 cites W1966874215 @default.
• W2146147975 cites W1968917601 @default.
• W2146147975 cites W1973998028 @default.
• W2146147975 cites W1975271591 @default.
• W2146147975 cites W1980290821 @default.
• W2146147975 cites W1983315122 @default.
• W2146147975 cites W1989569167 @default.
• W2146147975 cites W1990063593 @default.
• W2146147975 cites W1992297547 @default.
• W2146147975 cites W1996424575 @default.
• W2146147975 cites W1996884513 @default.
• W2146147975 cites W1998144416 @default.
• W2146147975 cites W1998172061 @default.
• W2146147975 cites W2004650501 @default.
• W2146147975 cites W2014530831 @default.
• W2146147975 cites W2020823395 @default.
• W2146147975 cites W2022588802 @default.
• W2146147975 cites W2022972918 @default.
• W2146147975 cites W2049644065 @default.
• W2146147975 cites W2053580123 @default.
• W2146147975 cites W2053866069 @default.
• W2146147975 cites W2064616098 @default.
• W2146147975 cites W2067323403 @default.
• W2146147975 cites W2068710028 @default.
• W2146147975 cites W2094582582 @default.
• W2146147975 cites W2096615527 @default.
• W2146147975 cites W2111578630 @default.
• W2146147975 cites W2118721994 @default.
• W2146147975 cites W2119061302 @default.
• W2146147975 cites W2140914496 @default.
• W2146147975 cites W2155701748 @default.
• W2146147975 cites W2160438870 @default.
• W2146147975 cites W2164993962 @default.
• W2146147975 cites W2165836601 @default.
• W2146147975 cites W2168524266 @default.
• W2146147975 cites W2323811200 @default.
• W2146147975 cites W2329523474 @default.
• W2146147975 cites W2332297720 @default.
• W2146147975 doi "https://doi.org/10.1111/j.1471-4159.1992.tb10034.x" @default.
• W2146147975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1313850" @default.
• W2146147975 hasPublicationYear "1992" @default.
• W2146147975 type Work @default.
• W2146147975 sameAs 2146147975 @default.
• W2146147975 citedByCount "21" @default.
• W2146147975 countsByYear W21461479752020 @default.
• W2146147975 countsByYear W21461479752023 @default.
• W2146147975 crossrefType "journal-article" @default.
• W2146147975 hasAuthorship W2146147975A5034151735 @default.
• W2146147975 hasAuthorship W2146147975A5047389602 @default.
• W2146147975 hasAuthorship W2146147975A5052263203 @default.
• W2146147975 hasAuthorship W2146147975A5082694775 @default.
• W2146147975 hasConcept C108625454 @default.
• W2146147975 hasConcept C170493617 @default.
• W2146147975 hasConcept C17093226 @default.
• W2146147975 hasConcept C185592680 @default.
• W2146147975 hasConcept C2776715637 @default.
• W2146147975 hasConcept C2776841590 @default.
• W2146147975 hasConcept C2777427919 @default.
• W2146147975 hasConcept C54355233 @default.
• W2146147975 hasConcept C55493867 @default.
• W2146147975 hasConcept C62231903 @default.
• W2146147975 hasConcept C79879829 @default.
• W2146147975 hasConcept C81885089 @default.
• W2146147975 hasConcept C86803240 @default.
• W2146147975 hasConceptScore W2146147975C108625454 @default.
• W2146147975 hasConceptScore W2146147975C170493617 @default.
• W2146147975 hasConceptScore W2146147975C17093226 @default.
• W2146147975 hasConceptScore W2146147975C185592680 @default.
• W2146147975 hasConceptScore W2146147975C2776715637 @default.
• W2146147975 hasConceptScore W2146147975C2776841590 @default.
• W2146147975 hasConceptScore W2146147975C2777427919 @default.
• W2146147975 hasConceptScore W2146147975C54355233 @default.
• W2146147975 hasConceptScore W2146147975C55493867 @default.
• W2146147975 hasConceptScore W2146147975C62231903 @default.
• W2146147975 hasConceptScore W2146147975C79879829 @default.
• W2146147975 hasConceptScore W2146147975C81885089 @default.
• W2146147975 hasConceptScore W2146147975C86803240 @default.
• W2146147975 hasIssue "5" @default.
• W2146147975 hasLocation W21461479751 @default.
• W2146147975 hasLocation W21461479752 @default.
• W2146147975 hasOpenAccess W2146147975 @default.
• W2146147975 hasPrimaryLocation W21461479751 @default.
• W2146147975 hasRelatedWork W1565199071 @default.
• W2146147975 hasRelatedWork W1800620245 @default.
• W2146147975 hasRelatedWork W1895522077 @default.
• W2146147975 hasRelatedWork W2001908867 @default.
• W2146147975 hasRelatedWork W2022972918 @default.
• W2146147975 hasRelatedWork W2036711370 @default.

• next