FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146155997> ?p ?o ?g. }

• W2146155997 endingPage "e439" @default.
• W2146155997 startingPage "e439" @default.
• W2146155997 abstract "Hookworm infection is a major cause of disease burden for humans. Recent studies have described hookworm-related immunosuppression in endemic populations and animal models. A Tissue Inhibitor of Metalloproteases (Ac-TMP-1) has been identified as one of the most abundant proteins released by the adult parasite. We investigated the effect of recombinant Ac-TMP-1 on dendritic cell (DC) and T cell function. Splenic T cells from C57BL/6 mice injected with Ac-TMP-1 showed reduced proliferation to restimulation with anti CD3 or bystander antigens such as OVA. Incubation of bone marrow-derived DCs with Ac-TMP-1 decreased MHC Class I and, especially, Class II expression but increased CD86 and IL-10 expression. Co-incubation of splenic T cells with DCs pulsed with Ac-TMP-1 induced their differentiation into CD4+ and, particularly, CD8+ CD25+Foxp3+ T cells that expressed IL-10. These cells were able to suppress proliferation of naïve and activated CD4+ T cells by TGF-Β-dependent (CD4+ suppressors) or independent (CD8+ suppressors) mechanisms. Priming of DCs with non-hookworm antigens, such as OVA, did not result in the generation of suppressor T cells. These data indicate that Ac-TMP-1 initiates the development of a regulatory response through modifications in DC function and generation of suppressor T cells. This is the first report to propose a role of suppressor CD8+ T cells in gastrointestinal helminthic infections." @default.
• W2146155997 created "2016-06-24" @default.
• W2146155997 creator A5001658011 @default.
• W2146155997 creator A5032210585 @default.
• W2146155997 creator A5089413478 @default.
• W2146155997 date "2009-05-19" @default.
• W2146155997 modified "2023-10-14" @default.
• W2146155997 title "The Hookworm Tissue Inhibitor of Metalloproteases (Ac-TMP-1) Modifies Dendritic Cell Function and Induces Generation of CD4 and CD8 Suppressor T Cells" @default.
• W2146155997 cites W1568217877 @default.
• W2146155997 cites W1612041908 @default.
• W2146155997 cites W1966561511 @default.
• W2146155997 cites W1969520940 @default.
• W2146155997 cites W1976206009 @default.
• W2146155997 cites W1981355586 @default.
• W2146155997 cites W1983898779 @default.
• W2146155997 cites W2001574304 @default.
• W2146155997 cites W2009042953 @default.
• W2146155997 cites W2013160761 @default.
• W2146155997 cites W2028727579 @default.
• W2146155997 cites W2035548685 @default.
• W2146155997 cites W2037912735 @default.
• W2146155997 cites W2041352234 @default.
• W2146155997 cites W2048425629 @default.
• W2146155997 cites W2050151794 @default.
• W2146155997 cites W2052819863 @default.
• W2146155997 cites W2052898838 @default.
• W2146155997 cites W2060078710 @default.
• W2146155997 cites W2066996164 @default.
• W2146155997 cites W2069701927 @default.
• W2146155997 cites W2082202341 @default.
• W2146155997 cites W2092743430 @default.
• W2146155997 cites W2093110992 @default.
• W2146155997 cites W2094441174 @default.
• W2146155997 cites W2100067350 @default.
• W2146155997 cites W2102201378 @default.
• W2146155997 cites W2117914185 @default.
• W2146155997 cites W2143445696 @default.
• W2146155997 cites W2143918380 @default.
• W2146155997 cites W2151473667 @default.
• W2146155997 cites W2159408865 @default.
• W2146155997 cites W2163569408 @default.
• W2146155997 cites W2189339597 @default.
• W2146155997 cites W2462085614 @default.
• W2146155997 cites W4236369019 @default.
• W2146155997 cites W77477439 @default.
• W2146155997 doi "https://doi.org/10.1371/journal.pntd.0000439" @default.
• W2146155997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2678263" @default.
• W2146155997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19468296" @default.
• W2146155997 hasPublicationYear "2009" @default.
• W2146155997 type Work @default.
• W2146155997 sameAs 2146155997 @default.
• W2146155997 citedByCount "41" @default.
• W2146155997 countsByYear W21461559972012 @default.
• W2146155997 countsByYear W21461559972013 @default.
• W2146155997 countsByYear W21461559972014 @default.
• W2146155997 countsByYear W21461559972015 @default.
• W2146155997 countsByYear W21461559972016 @default.
• W2146155997 countsByYear W21461559972017 @default.
• W2146155997 countsByYear W21461559972018 @default.
• W2146155997 countsByYear W21461559972020 @default.
• W2146155997 countsByYear W21461559972021 @default.
• W2146155997 countsByYear W21461559972022 @default.
• W2146155997 crossrefType "journal-article" @default.
• W2146155997 hasAuthorship W2146155997A5001658011 @default.
• W2146155997 hasAuthorship W2146155997A5032210585 @default.
• W2146155997 hasAuthorship W2146155997A5089413478 @default.
• W2146155997 hasBestOaLocation W21461559971 @default.
• W2146155997 hasConcept C100701293 @default.
• W2146155997 hasConcept C104317684 @default.
• W2146155997 hasConcept C129374314 @default.
• W2146155997 hasConcept C147483822 @default.
• W2146155997 hasConcept C154317977 @default.
• W2146155997 hasConcept C167672396 @default.
• W2146155997 hasConcept C179185449 @default.
• W2146155997 hasConcept C202751555 @default.
• W2146155997 hasConcept C203014093 @default.
• W2146155997 hasConcept C2776090121 @default.
• W2146155997 hasConcept C2778170410 @default.
• W2146155997 hasConcept C2781101188 @default.
• W2146155997 hasConcept C39347974 @default.
• W2146155997 hasConcept C55493867 @default.
• W2146155997 hasConcept C55721878 @default.
• W2146155997 hasConcept C59822182 @default.
• W2146155997 hasConcept C67662055 @default.
• W2146155997 hasConcept C79484868 @default.
• W2146155997 hasConcept C81444415 @default.
• W2146155997 hasConcept C86803240 @default.
• W2146155997 hasConcept C8891405 @default.
• W2146155997 hasConcept C95444343 @default.
• W2146155997 hasConceptScore W2146155997C100701293 @default.
• W2146155997 hasConceptScore W2146155997C104317684 @default.
• W2146155997 hasConceptScore W2146155997C129374314 @default.
• W2146155997 hasConceptScore W2146155997C147483822 @default.
• W2146155997 hasConceptScore W2146155997C154317977 @default.
• W2146155997 hasConceptScore W2146155997C167672396 @default.
• W2146155997 hasConceptScore W2146155997C179185449 @default.
• W2146155997 hasConceptScore W2146155997C202751555 @default.
• W2146155997 hasConceptScore W2146155997C203014093 @default.

• next