Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146156912> ?p ?o ?g. }
- W2146156912 endingPage "151" @default.
- W2146156912 startingPage "141" @default.
- W2146156912 abstract "Cells of Saccharomyces cerevisiae lacking Apq12, a nuclear envelope (NE)-endoplasmic reticulum (ER) integral membrane protein, are defective in assembly of nuclear pore complexes (NPCs), possibly because of defects in regulating membrane fluidity. We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12 Δ. Cells carrying the temperature-sensitive brr6-1 allele have been shown to have defects in nucleoporin localization, mRNA metabolism and nuclear transport. Electron microscopy revealed that brr6-1 cells have gross NE abnormalities and proliferation of the ER. brr6-1 cells were hypersensitive to compounds that affect membrane biophysical properties and to inhibitors of lipid biosynthetic pathways, and displayed strong genetic interactions with genes encoding non-essential lipid biosynthetic enzymes. Strikingly, brr6-1 cells accumulated, in or near the NE, elevated levels of the two classes of neutral lipids, steryl esters and triacylglycerols, and over-accumulated sterols when they were provided exogenously. Although neutral lipid synthesis is dispensable in wild-type cells, viability of brr6-1 cells was fully dependent on neutral lipid production. These data indicate that Brr6 has an essential function in regulating lipid homeostasis in the NE-ER, thereby impacting NPC formation and nucleocytoplasmic transport." @default.
- W2146156912 created "2016-06-24" @default.
- W2146156912 creator A5034412798 @default.
- W2146156912 creator A5035021837 @default.
- W2146156912 creator A5058071862 @default.
- W2146156912 creator A5061031999 @default.
- W2146156912 creator A5075756166 @default.
- W2146156912 creator A5084891394 @default.
- W2146156912 date "2010-01-01" @default.
- W2146156912 modified "2023-09-29" @default.
- W2146156912 title "Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum" @default.
- W2146156912 cites W1483746134 @default.
- W2146156912 cites W1490597223 @default.
- W2146156912 cites W1506421364 @default.
- W2146156912 cites W1543229275 @default.
- W2146156912 cites W1575870386 @default.
- W2146156912 cites W1963796773 @default.
- W2146156912 cites W1979313147 @default.
- W2146156912 cites W1984354326 @default.
- W2146156912 cites W1991776028 @default.
- W2146156912 cites W1993562651 @default.
- W2146156912 cites W2001805380 @default.
- W2146156912 cites W2002192641 @default.
- W2146156912 cites W2005855998 @default.
- W2146156912 cites W2007396399 @default.
- W2146156912 cites W2011209055 @default.
- W2146156912 cites W2015468911 @default.
- W2146156912 cites W2018917785 @default.
- W2146156912 cites W2020725477 @default.
- W2146156912 cites W2020803942 @default.
- W2146156912 cites W2022279792 @default.
- W2146156912 cites W2028123717 @default.
- W2146156912 cites W2029103676 @default.
- W2146156912 cites W2034804054 @default.
- W2146156912 cites W2041843816 @default.
- W2146156912 cites W2043237666 @default.
- W2146156912 cites W2046360023 @default.
- W2146156912 cites W2048492672 @default.
- W2146156912 cites W2053497997 @default.
- W2146156912 cites W2057664258 @default.
- W2146156912 cites W2058949200 @default.
- W2146156912 cites W2061275835 @default.
- W2146156912 cites W2072185974 @default.
- W2146156912 cites W2076585544 @default.
- W2146156912 cites W2077068031 @default.
- W2146156912 cites W2100088060 @default.
- W2146156912 cites W2102376346 @default.
- W2146156912 cites W2102651270 @default.
- W2146156912 cites W2105821361 @default.
- W2146156912 cites W2106132742 @default.
- W2146156912 cites W2108442683 @default.
- W2146156912 cites W2113937251 @default.
- W2146156912 cites W2130071037 @default.
- W2146156912 cites W2132468746 @default.
- W2146156912 cites W2138242591 @default.
- W2146156912 cites W2140187466 @default.
- W2146156912 cites W2147416651 @default.
- W2146156912 cites W2158248025 @default.
- W2146156912 cites W2159745862 @default.
- W2146156912 cites W2161302855 @default.
- W2146156912 cites W2163503448 @default.
- W2146156912 cites W2168734886 @default.
- W2146156912 cites W2169323364 @default.
- W2146156912 cites W2297853795 @default.
- W2146156912 cites W2415619082 @default.
- W2146156912 cites W4245896411 @default.
- W2146156912 cites W955649814 @default.
- W2146156912 doi "https://doi.org/10.1242/jcs.055046" @default.
- W2146156912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2794714" @default.
- W2146156912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20016074" @default.
- W2146156912 hasPublicationYear "2010" @default.
- W2146156912 type Work @default.
- W2146156912 sameAs 2146156912 @default.
- W2146156912 citedByCount "71" @default.
- W2146156912 countsByYear W21461569122012 @default.
- W2146156912 countsByYear W21461569122013 @default.
- W2146156912 countsByYear W21461569122014 @default.
- W2146156912 countsByYear W21461569122015 @default.
- W2146156912 countsByYear W21461569122016 @default.
- W2146156912 countsByYear W21461569122017 @default.
- W2146156912 countsByYear W21461569122018 @default.
- W2146156912 countsByYear W21461569122019 @default.
- W2146156912 countsByYear W21461569122020 @default.
- W2146156912 countsByYear W21461569122021 @default.
- W2146156912 countsByYear W21461569122022 @default.
- W2146156912 countsByYear W21461569122023 @default.
- W2146156912 crossrefType "journal-article" @default.
- W2146156912 hasAuthorship W2146156912A5034412798 @default.
- W2146156912 hasAuthorship W2146156912A5035021837 @default.
- W2146156912 hasAuthorship W2146156912A5058071862 @default.
- W2146156912 hasAuthorship W2146156912A5061031999 @default.
- W2146156912 hasAuthorship W2146156912A5075756166 @default.
- W2146156912 hasAuthorship W2146156912A5084891394 @default.
- W2146156912 hasBestOaLocation W21461569121 @default.
- W2146156912 hasConcept C126725582 @default.
- W2146156912 hasConcept C144647389 @default.
- W2146156912 hasConcept C158617107 @default.
- W2146156912 hasConcept C161200384 @default.