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- W2146162401 endingPage "1884" @default.
- W2146162401 startingPage "1871" @default.
- W2146162401 abstract "TGF-β family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads. Nevertheless, TGF-β family proteins induce highly complex programs of gene expression responses that are extensively regulated, and depend on the physiological context of the cells. Regulation of TGF-β signaling occurs at multiple levels, including TGF-β activation, formation, activation and destruction of functional TGF-β receptor complexes, activation and degradation of Smads, and formation of Smad transcription complexes at regulatory gene sequences that cooperate with a diverse set of DNA binding transcription factors and coregulators. Here we discuss recent insights into the roles of post-translational modifications and molecular interaction networks in the functions of receptors and Smads in TGF-β signal responses. These layers of regulation demonstrate how a simple signaling system can be coopted to exert exquisitely regulated, complex responses." @default.
- W2146162401 created "2016-06-24" @default.
- W2146162401 creator A5028904861 @default.
- W2146162401 creator A5060006875 @default.
- W2146162401 creator A5068725149 @default.
- W2146162401 date "2012-05-19" @default.
- W2146162401 modified "2023-10-11" @default.
- W2146162401 title "Post-translational regulation of TGF-β receptor and Smad signaling" @default.
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