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• W2146162698 abstract "textabstractThe story of allogeneic hematopoietic stem cell transplantation (allo-SCT) begins after theatomic bombings of Hiroshima and Nagasaki in 1945. It was observed that fallout radiationcaused dose-dependent depression of hematopoiesis 1. Research first focused on how to protectthe hematopoietic system from irradiation injury and it was discovered that infusion of spleenor marrow cells from a healthy donor restored hematopoiesis through the establishment ofhematopoietic donor chimerism in an irradiated recipient 2. This finding led to the realizationthat it might also be applied to treat hematological malignancies. In 1957, a new approach tohuman cancer treatment was reported: radiation and chemotherapy followed by the intravenousinfusion of healthy donor bone marrow 3,4. However, all the early clinical transplantation attemptsin the late 50’s and early 60’s failed due to, what was later discovered, inappropriatedonor selection. Eventually, in 1968, the first successful allogeneic bone marrow transplantationsusing human leukocyte antigen (HLA)-identical siblings was reported 5,6. More than fourdecades later, allogeneic hematopoietic stem cell transplantation (allo-SCT) is an establishedtreatment modality for patients with hematological malignancies, aplastic anemia, and inbornerrors of hematopoietic progenitor cells 7. The preferred donor for an allogeneic transplant is stillan HLA-identical sibling. However, as only 25-30% of patients have an HLA-matched siblingdonor available, hematopoietic stem cells (HSC) from HLA-matched-unrelated-donors areincreasingly used. Matched-unrelated-donors can be identified from the bone marrow donorworldwide registry, in which more than 10 million HLA-typed volunteer donors are registered 8.Currently, granulocyte-colony stimulating factor-mobilized peripheral blood stem cells arethe most common source of stem cells, as transplantation of these cells results in more rapidreconstitution compared to transplantation of bone marrow (BM) cells 9. However, for high-riskpatients the time to obtain a transplant from a suitable donor may be too long as the mediantime span between the start of the search and actual SCT is 4 months 10. In this case, more readilyavailable alternative stem cells sources including haplo-identical donors 11 or cord blood (CB) 12can be considered." @default.
• W2146162698 created "2016-06-24" @default.
• W2146162698 creator A5004073630 @default.
• W2146162698 date "2010-03-03" @default.
• W2146162698 modified "2023-09-27" @default.
• W2146162698 title "Regulatory T cells and immune tolerance after allogeneic hematopoietic stem cell transplantation" @default.
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