Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146163661> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2146163661 endingPage "2553" @default.
- W2146163661 startingPage "2549" @default.
- W2146163661 abstract "Purine bases and their bioisosteric analogs are widely used as building blocks in combinatorial chemistry. Recently a great number of fused pyrimidine derivatives became known as potential drug molecules against various types of proliferative diseases, caused by over-expression of protein kinases. One of the most important compound families are quinazolines : e.g. the best inhibitor of EGFR tyrosine kinase is PD153035 (6,7-dimethoxy-4-(3'-bromophenyl)amino-quinazoline) and IRESSA (gefitinib, ZD1839), developed from this compound family, is presently the only one approved and granted drug by the FDA for the treatment of advanced non-small-cell lung cancer (NSCLC). KF31327 (3-ethyl-8-[2-(4-hydroxymethylpiperidino)benzylamino]-2,3-dihydro-1H-imidazo[4,5-g]-quinazoline-2-thione dihydrochloride) from this group, showed significantly higher inhibitory activity on cyclic GMP-specific phosphodiesterase compared with those of sildenafil (Viagra). The synthetic procedures of the example compounds are based on imidoyl chloride intermediates that were prepared from the appropriate 3H-quinazoline-4-ones. Although the key intermediates, quinazoline-4-ones, have been known since more than hundred years, their synthetic procedures have been improved much only in the past ten years. In this paper we reviewed the efficient synthetic methods of quinazolin-4-ones, and presented a novel, reliable method for their synthesis. There was no considerable effect of microwave-, or traditional thermal activation on the yield and compound purity." @default.
- W2146163661 created "2016-06-24" @default.
- W2146163661 creator A5021796062 @default.
- W2146163661 creator A5029381999 @default.
- W2146163661 creator A5047419813 @default.
- W2146163661 creator A5059315217 @default.
- W2146163661 creator A5073849664 @default.
- W2146163661 creator A5089066453 @default.
- W2146163661 creator A5091770704 @default.
- W2146163661 date "2004-10-01" @default.
- W2146163661 modified "2023-10-18" @default.
- W2146163661 title "Improved, High Yield Synthesis of 3H-Quinazolin-4-ones, the Key Intermediates of Recently Developed Drugs" @default.
- W2146163661 doi "https://doi.org/10.2174/0929867043364423" @default.
- W2146163661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15544462" @default.
- W2146163661 hasPublicationYear "2004" @default.
- W2146163661 type Work @default.
- W2146163661 sameAs 2146163661 @default.
- W2146163661 citedByCount "36" @default.
- W2146163661 countsByYear W21461636612012 @default.
- W2146163661 countsByYear W21461636612014 @default.
- W2146163661 countsByYear W21461636612015 @default.
- W2146163661 countsByYear W21461636612016 @default.
- W2146163661 countsByYear W21461636612017 @default.
- W2146163661 countsByYear W21461636612018 @default.
- W2146163661 countsByYear W21461636612020 @default.
- W2146163661 countsByYear W21461636612022 @default.
- W2146163661 countsByYear W21461636612023 @default.
- W2146163661 crossrefType "journal-article" @default.
- W2146163661 hasAuthorship W2146163661A5021796062 @default.
- W2146163661 hasAuthorship W2146163661A5029381999 @default.
- W2146163661 hasAuthorship W2146163661A5047419813 @default.
- W2146163661 hasAuthorship W2146163661A5059315217 @default.
- W2146163661 hasAuthorship W2146163661A5073849664 @default.
- W2146163661 hasAuthorship W2146163661A5089066453 @default.
- W2146163661 hasAuthorship W2146163661A5091770704 @default.
- W2146163661 hasConcept C134121241 @default.
- W2146163661 hasConcept C170493617 @default.
- W2146163661 hasConcept C184235292 @default.
- W2146163661 hasConcept C185592680 @default.
- W2146163661 hasConcept C191897082 @default.
- W2146163661 hasConcept C192562407 @default.
- W2146163661 hasConcept C21951064 @default.
- W2146163661 hasConcept C2778866207 @default.
- W2146163661 hasConcept C2779321679 @default.
- W2146163661 hasConcept C2779438470 @default.
- W2146163661 hasConcept C2780035454 @default.
- W2146163661 hasConcept C2780580887 @default.
- W2146163661 hasConcept C55493867 @default.
- W2146163661 hasConcept C71240020 @default.
- W2146163661 hasConcept C71924100 @default.
- W2146163661 hasConcept C98274493 @default.
- W2146163661 hasConceptScore W2146163661C134121241 @default.
- W2146163661 hasConceptScore W2146163661C170493617 @default.
- W2146163661 hasConceptScore W2146163661C184235292 @default.
- W2146163661 hasConceptScore W2146163661C185592680 @default.
- W2146163661 hasConceptScore W2146163661C191897082 @default.
- W2146163661 hasConceptScore W2146163661C192562407 @default.
- W2146163661 hasConceptScore W2146163661C21951064 @default.
- W2146163661 hasConceptScore W2146163661C2778866207 @default.
- W2146163661 hasConceptScore W2146163661C2779321679 @default.
- W2146163661 hasConceptScore W2146163661C2779438470 @default.
- W2146163661 hasConceptScore W2146163661C2780035454 @default.
- W2146163661 hasConceptScore W2146163661C2780580887 @default.
- W2146163661 hasConceptScore W2146163661C55493867 @default.
- W2146163661 hasConceptScore W2146163661C71240020 @default.
- W2146163661 hasConceptScore W2146163661C71924100 @default.
- W2146163661 hasConceptScore W2146163661C98274493 @default.
- W2146163661 hasIssue "19" @default.
- W2146163661 hasLocation W21461636611 @default.
- W2146163661 hasLocation W21461636612 @default.
- W2146163661 hasOpenAccess W2146163661 @default.
- W2146163661 hasPrimaryLocation W21461636611 @default.
- W2146163661 hasRelatedWork W1969883932 @default.
- W2146163661 hasRelatedWork W2045486039 @default.
- W2146163661 hasRelatedWork W2065576471 @default.
- W2146163661 hasRelatedWork W2078216937 @default.
- W2146163661 hasRelatedWork W2080648017 @default.
- W2146163661 hasRelatedWork W2187035959 @default.
- W2146163661 hasRelatedWork W2969621410 @default.
- W2146163661 hasRelatedWork W3211998852 @default.
- W2146163661 hasRelatedWork W4302360171 @default.
- W2146163661 hasRelatedWork W93672847 @default.
- W2146163661 hasVolume "11" @default.
- W2146163661 isParatext "false" @default.
- W2146163661 isRetracted "false" @default.
- W2146163661 magId "2146163661" @default.
- W2146163661 workType "article" @default.