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• W2146165616 endingPage "691" @default.
• W2146165616 startingPage "643" @default.
• W2146165616 abstract "The four essential building blocks of cells are proteins, nucleic acids, lipids, and glycans. Also referred to as carbohydrates, glycans are composed of saccharides that are typically linked to lipids and proteins in the secretory pathway. Glycans are highly abundant and diverse biopolymers, yet their functions have remained relatively obscure. This is changing with the advent of genetic reagents and techniques that in the past decade have uncovered many essential roles of specific glycan linkages in living organisms. Glycans appear to modulate biological processes in the development and function of multiple physiologic systems, in part by regulating protein-protein and cell-cell interactions. Moreover, dysregulation of glycan synthesis represents the etiology for a growing number of human genetic diseases. The study of glycans, known as glycobiology, has entered an era of renaissance that coincides with the acquisition of complete genome sequences for multiple organisms and an increased focus upon how posttranslational modifications to protein contribute to the complexity of events mediating normal and disease physiology. Glycan production and modification comprise an estimated 1% of genes in the mammalian genome. Many of these genes encode enzymes termed glycosyltransferases and glycosidases that reside in the Golgi apparatus where they play the major role in constructing the glycan repertoire that is found at the cell surface and among extracellular compartments. We present a review of the recently established functions of glycan structures in the context of mammalian genetic studies focused upon the mouse and human species. Nothing tends so much to the advancement of knowledge as the application of a new instrument. The native intellectual powers of men in different times are not so much the causes of the different success of their labours, as the peculiar nature of the means and artificial resources in their possession. T. Hager: Force of Nature (1)" @default.
• W2146165616 created "2016-06-24" @default.
• W2146165616 creator A5022635870 @default.
• W2146165616 creator A5059962014 @default.
• W2146165616 date "2003-06-01" @default.
• W2146165616 modified "2023-10-17" @default.
• W2146165616 title "A Genetic Approach to Mammalian Glycan Function" @default.
• W2146165616 cites W10838131 @default.
• W2146165616 cites W1491063745 @default.
• W2146165616 cites W1493639935 @default.
• W2146165616 cites W1497009792 @default.
• W2146165616 cites W1499310181 @default.
• W2146165616 cites W1519269060 @default.
• W2146165616 cites W1529507538 @default.
• W2146165616 cites W1531421007 @default.
• W2146165616 cites W1541131175 @default.
• W2146165616 cites W1541510915 @default.
• W2146165616 cites W1549963158 @default.
• W2146165616 cites W1552293911 @default.
• W2146165616 cites W1554631282 @default.
• W2146165616 cites W1563581237 @default.
• W2146165616 cites W1565550208 @default.
• W2146165616 cites W1567324919 @default.
• W2146165616 cites W1570480239 @default.
• W2146165616 cites W1571088225 @default.
• W2146165616 cites W1572408887 @default.
• W2146165616 cites W1574150827 @default.
• W2146165616 cites W1575425448 @default.
• W2146165616 cites W1581627079 @default.
• W2146165616 cites W1582944414 @default.
• W2146165616 cites W1587171635 @default.
• W2146165616 cites W1588418288 @default.
• W2146165616 cites W1589271731 @default.
• W2146165616 cites W1599042760 @default.
• W2146165616 cites W1639179179 @default.
• W2146165616 cites W1641219563 @default.
• W2146165616 cites W1641954328 @default.
• W2146165616 cites W16534552 @default.
• W2146165616 cites W1673564132 @default.
• W2146165616 cites W1827983837 @default.
• W2146165616 cites W1833458012 @default.
• W2146165616 cites W1854949006 @default.
• W2146165616 cites W1915912984 @default.
• W2146165616 cites W1963757547 @default.
• W2146165616 cites W1963819227 @default.
• W2146165616 cites W1964110277 @default.
• W2146165616 cites W1964124757 @default.
• W2146165616 cites W1964709514 @default.
• W2146165616 cites W1965399166 @default.
• W2146165616 cites W1966844606 @default.
• W2146165616 cites W1968104539 @default.
• W2146165616 cites W1968146121 @default.
• W2146165616 cites W1970122244 @default.
• W2146165616 cites W1971249148 @default.
• W2146165616 cites W1971351550 @default.
• W2146165616 cites W1974384968 @default.
• W2146165616 cites W1975456619 @default.
• W2146165616 cites W1975699819 @default.
• W2146165616 cites W1976666998 @default.
• W2146165616 cites W1976790385 @default.
• W2146165616 cites W1976962628 @default.
• W2146165616 cites W1977041874 @default.
• W2146165616 cites W1977576363 @default.
• W2146165616 cites W1980988191 @default.
• W2146165616 cites W1981382192 @default.
• W2146165616 cites W1981502698 @default.
• W2146165616 cites W1982641454 @default.
• W2146165616 cites W1983602468 @default.
• W2146165616 cites W1985702485 @default.
• W2146165616 cites W1986044155 @default.
• W2146165616 cites W1986067115 @default.
• W2146165616 cites W1986389110 @default.
• W2146165616 cites W1987909360 @default.
• W2146165616 cites W1988043125 @default.
• W2146165616 cites W1989556421 @default.
• W2146165616 cites W1990286006 @default.
• W2146165616 cites W1990803574 @default.
• W2146165616 cites W1990891647 @default.
• W2146165616 cites W1991528365 @default.
• W2146165616 cites W1991607152 @default.
• W2146165616 cites W1992092712 @default.
• W2146165616 cites W1992778614 @default.
• W2146165616 cites W1993931442 @default.
• W2146165616 cites W1994018335 @default.
• W2146165616 cites W1994708908 @default.
• W2146165616 cites W1995243908 @default.
• W2146165616 cites W1995615216 @default.
• W2146165616 cites W1996149510 @default.
• W2146165616 cites W1996956001 @default.
• W2146165616 cites W1997915860 @default.
• W2146165616 cites W1999416747 @default.
• W2146165616 cites W1999425810 @default.
• W2146165616 cites W1999798731 @default.
• W2146165616 cites W1999841276 @default.
• W2146165616 cites W2001091272 @default.
• W2146165616 cites W2002552794 @default.
• W2146165616 cites W2002888609 @default.
• W2146165616 cites W2003220876 @default.

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