FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146173811> ?p ?o ?g. }

• W2146173811 endingPage "H1305" @default.
• W2146173811 startingPage "H1294" @default.
• W2146173811 abstract "Intramural gradients of intracellular Ca(2+) (Ca(i)(2+)) Ca(i)(2+) handling, Ca(i)(2+) oscillations, and Ca(i)(2+) transient (CaT) alternans may be important in long-duration ventricular fibrillation (LDVF). However, previous studies of Ca(i)(2+) handling have been limited to recordings from the heart surface during short-duration ventricular fibrillation. To examine whether abnormalities of intramural Ca(i)(2+) handling contribute to LDVF, we measured membrane voltage (V(m)) and Ca(i)(2+) during pacing and LDVF in six perfused canine hearts using five eight-fiber optrodes. Measurements were grouped into epicardial, midwall, and endocardial layers. We found that during pacing at 350-ms cycle length, CaT duration was slightly longer (by ≃10%) in endocardial layers than in epicardial layers, whereas action potential duration (APD) exhibited no difference. Rapid pacing at 150-ms cycle length caused alternans in both APD (APD-ALT) and CaT amplitude (CaA-ALT) without significant transmural differences. For 93% of optrode recordings, CaA-ALT was transmurally concordant, whereas APD-ALT was either concordant (36%) or discordant (54%), suggesting that APD-ALT was not caused by CaA-ALT. During LDVF, V(m) and Ca(i)(2+) progressively desynchronized when not every action potential was followed by a CaT. Such desynchronization developed faster in the epicardium than in the other layers. In addition, CaT duration strongly increased (by ∼240% at 5 min of LDVF), whereas APD shortened (by ∼17%). CaT rises always followed V(m) upstrokes during pacing and LDVF. In conclusion, the fact that V(m) upstrokes always preceded CaTs indicates that spontaneous Ca(i)(2+) oscillations in the working myocardium were not likely the reason for LDVF maintenance. Strong V(m)-Ca(i)(2+) desynchronization and the occurrence of long CaTs during LDVF indicate severely impaired Ca(i)(2+) handling and may potentially contribute to LDVF maintenance." @default.
• W2146173811 created "2016-06-24" @default.
• W2146173811 creator A5010917142 @default.
• W2146173811 creator A5032109161 @default.
• W2146173811 creator A5086265230 @default.
• W2146173811 date "2012-03-15" @default.
• W2146173811 modified "2023-10-16" @default.
• W2146173811 title "Intramural optical mapping of Vm and Cai2+ during long-duration ventricular fibrillation in canine hearts" @default.
• W2146173811 cites W1968605111 @default.
• W2146173811 cites W1973054195 @default.
• W2146173811 cites W1973228369 @default.
• W2146173811 cites W1975151540 @default.
• W2146173811 cites W1981927680 @default.
• W2146173811 cites W1985851674 @default.
• W2146173811 cites W1991643791 @default.
• W2146173811 cites W2003654791 @default.
• W2146173811 cites W2024923246 @default.
• W2146173811 cites W2028163040 @default.
• W2146173811 cites W2031053544 @default.
• W2146173811 cites W2031445070 @default.
• W2146173811 cites W2034222977 @default.
• W2146173811 cites W2040795583 @default.
• W2146173811 cites W2044265637 @default.
• W2146173811 cites W2068769799 @default.
• W2146173811 cites W2073991158 @default.
• W2146173811 cites W2077129671 @default.
• W2146173811 cites W2088020365 @default.
• W2146173811 cites W2095606578 @default.
• W2146173811 cites W2096813520 @default.
• W2146173811 cites W2101036898 @default.
• W2146173811 cites W2102489764 @default.
• W2146173811 cites W2106796171 @default.
• W2146173811 cites W2109944491 @default.
• W2146173811 cites W2114492848 @default.
• W2146173811 cites W2115870475 @default.
• W2146173811 cites W2116895717 @default.
• W2146173811 cites W2119277805 @default.
• W2146173811 cites W2121135274 @default.
• W2146173811 cites W2121411601 @default.
• W2146173811 cites W2126712564 @default.
• W2146173811 cites W2136746571 @default.
• W2146173811 cites W2142432219 @default.
• W2146173811 cites W2145232273 @default.
• W2146173811 cites W2145264435 @default.
• W2146173811 cites W2148734617 @default.
• W2146173811 cites W2157409331 @default.
• W2146173811 cites W2162530972 @default.
• W2146173811 cites W2167897172 @default.
• W2146173811 cites W2171148992 @default.
• W2146173811 cites W4246665087 @default.
• W2146173811 cites W4247267210 @default.
• W2146173811 cites W57048595 @default.
• W2146173811 doi "https://doi.org/10.1152/ajpheart.00426.2011" @default.
• W2146173811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3311483" @default.
• W2146173811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22268104" @default.
• W2146173811 hasPublicationYear "2012" @default.
• W2146173811 type Work @default.
• W2146173811 sameAs 2146173811 @default.
• W2146173811 citedByCount "13" @default.
• W2146173811 countsByYear W21461738112012 @default.
• W2146173811 countsByYear W21461738112013 @default.
• W2146173811 countsByYear W21461738112014 @default.
• W2146173811 countsByYear W21461738112015 @default.
• W2146173811 countsByYear W21461738112018 @default.
• W2146173811 countsByYear W21461738112019 @default.
• W2146173811 countsByYear W21461738112020 @default.
• W2146173811 countsByYear W21461738112022 @default.
• W2146173811 crossrefType "journal-article" @default.
• W2146173811 hasAuthorship W2146173811A5010917142 @default.
• W2146173811 hasAuthorship W2146173811A5032109161 @default.
• W2146173811 hasAuthorship W2146173811A5086265230 @default.
• W2146173811 hasBestOaLocation W21461738112 @default.
• W2146173811 hasConcept C126322002 @default.
• W2146173811 hasConcept C164705383 @default.
• W2146173811 hasConcept C185592680 @default.
• W2146173811 hasConcept C2777356233 @default.
• W2146173811 hasConcept C2779161974 @default.
• W2146173811 hasConcept C2780451601 @default.
• W2146173811 hasConcept C2781005686 @default.
• W2146173811 hasConcept C28289500 @default.
• W2146173811 hasConcept C71924100 @default.
• W2146173811 hasConceptScore W2146173811C126322002 @default.
• W2146173811 hasConceptScore W2146173811C164705383 @default.
• W2146173811 hasConceptScore W2146173811C185592680 @default.
• W2146173811 hasConceptScore W2146173811C2777356233 @default.
• W2146173811 hasConceptScore W2146173811C2779161974 @default.
• W2146173811 hasConceptScore W2146173811C2780451601 @default.
• W2146173811 hasConceptScore W2146173811C2781005686 @default.
• W2146173811 hasConceptScore W2146173811C28289500 @default.
• W2146173811 hasConceptScore W2146173811C71924100 @default.
• W2146173811 hasIssue "6" @default.
• W2146173811 hasLocation W21461738111 @default.
• W2146173811 hasLocation W21461738112 @default.
• W2146173811 hasLocation W21461738113 @default.
• W2146173811 hasLocation W21461738114 @default.
• W2146173811 hasOpenAccess W2146173811 @default.
• W2146173811 hasPrimaryLocation W21461738111 @default.
• W2146173811 hasRelatedWork W1489387013 @default.

• next